In the relatively short period since Cryptosporidium was recognised as a human pathogen, and that it could be transmitted in water as well as directly between animals and people, it has been the subject of intense investigations. Its status as an opportunistic pathogen, especially in AIDS patients, and the lack of effective anti-cryptosporidial drugs have served to emphasise the public health importance of this organism. This has to some extent overshadowed the fact that Cryptosporidium is also an important pathogen of domestic animals and wildlife.

In recent years, the application of molecular biology and culture techniques have had an enormous impact on our understanding of the aetiological agents of cryptosporidial infections and our ability to study the causative agents in the laboratory. As a consequence, a wealth of information and novel data has been produced during the last 3-4 years, particularly in the areas of taxonomy, biology, pathogenesis, epidemiology - particularly zoonotic and water borne transmission, and treatment.

It is thus very timely to bring together in this book the international research community involved to review the major advances in research and identify the important research priorities for the future, thus enabling as wide an audience as possible to benefit from and share in this comprehensive look at Cryptosporidium and cryptosporidiosis.


Parasitologists, microbiologists, veterinarians, physicians, gastroenterologists, water quality professionals.

Table of Contents

Preface (A. Thompson). Introduction: Cryptosporidium: from molecules to disease (G. Meinke). Cryptosporidiosis - Aetiology, Infectivity and Pathogenesis. Cryptosporidium: they probably taste like chicken (S.J. Upton). Cryptosporidium: from molecules to disease (R. Fayer). Cryptosporidium parvum: infectivity, pathogenesis and the host-parasite relationship (C.L. Chappell, P.C. Okhuysen et al.). What is the clinical and zoonotic significance of cryptosporidiosis in domestic animals and wildlife (M.E. Olson, B.J. Ralston et al.). Extended Abstracts. Control of Cryptosporidium parvum infection and the role of IL-4 in two strains of inbred mice (C.A. Notley, S.A.C. Mcdonald et al.). Human peripheral CD8+CD103+ T-lymphocyte transmigration through inverted Cryptosporidium parvum sporozoite infected HCT-8 cell monolayers (G. Gargala, A. Delaunay et al.). Cryptosporidium parvum volunteer study: infectivity and immunity (C.L. Chappell, P.C. Okhuysen et al.). Transmission of human genotype 1 Cryptosporidium parvum into lambs (M. Giles, D.C. Warhurs et al.). A longitudinal study of Cryptosporidium prevalence and its impact on performance in feedlot cattle (B.J. Ralston, M.E. Olson et al.). Identification and characterisation of the antigenic CPA135 protein (F. Tosini, A. Agnoli et al.). A permanent method for detecting Cryptosporidium parvum life cycle stages in in vitro culture (H.V. Smith, R.A. Nichols et al.). Successful cultivation of Cryptosporidium reveals previously undescribed Gregarino-like developmental stages (N. Hijjawi, B.P. Meloni et al.). Epidemiology and species differentiation. Cryptosporidium as a public health challenge (R.M. Chalmers). The zoonotic potential of Cypt


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© 2003
Elsevier Science
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About the editors

U.M. Ryan

Affiliations and Expertise

Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA, Australia