Coronary Vasodilators assesses the state of knowledge of the pharmacological effects, the mechanisms responsible for these effects, and the therapeutic importance of classical drugs as well as recent medications on which experimental and clinical investigations are still too few to allow of definite judgment.
The book is organized into four chapters. Chapter I is devoted to the influences controlling coronary blood flow. Chapter II reviews the experimental methods commonly used in pharmacological research with a critical assessment of their possibilities and limitations. Chapter III discusses methods recommended by clinical research workers for evaluating the effectiveness of anti-anginal medications in the patient. Chapter IV describes pharmacology and clinical features of coronary vasodilators. The substances considered are group into four sections. The first contains the coronary vasodilator drugs actually used in cardiovascular therapeutics. The second consists of sympathicomimetic substances which modify general and local hemodynamic conditions profoundly and thus produce increased coronary flow. In the third section are brought together drugs used on man for particular therapeutic properties which have coronary vasodilator action, uncertain in the case of some, and which, for various reasons, cannot be used in the treatment of angina. The fourth section collects together a variety of substances, most of which are not drugs, reported in the literature as having vasodilator activity at coronary circulation level.
Preface Introduction I. Physiological Factors Determining The Coronary Blood Flow II. Critical Analysis of Methods for Measurement of Changes in the Lumen of the Coronary Vessels1. Methods on the Isolated Heart, Based on the Langendorff Technique 2. Methods on the Anaesthetized Entire Animal, with the Heart in Situ, Involving Cannulization of the Coronary Vessels (a) Methods for Measurement of Coronary Outflow (b) Methods for Measurement of Coronary Inflow 3. Methods on the Unanaesthetized, Entire Animal (a) The Thermostromuhr (b) The Nitrous Oxide Technique 4. The Calorimetric Method 5. Methods Based on the Employment of Radioactive Substances 6. Miscellaneous Non-Quantitative Methods (a) Lindner's Technique (b) Coronary Artériographie Technique
III. Clinical Methods for assessment of the Therapeutic Value of Anti-Anginal Medications1. Objective Methods Russek's Method Levy's Method Riseman's Method 2. Subjective Methods Greiner's Method 3. Conclusions on Methods of Clinical assessment
IV. Coronary Vasodilators: Pharmacology and Clinical Features Section 1. Coronary Vasodilators Used in Cardiovascular Therapy (A) Classical Coronary Vasodilators (B) Recent Coronary Vasodilators (C) Substances Credited with Coronary Vasodilator Properties Section 2. Sympathicomimetic Amines Section 3. Substances Having Coronary Vasodilator Effects, Certain or Uncertain, but Not Used as Such Section 4. Miscellaneous Substances General Considerations Bibliography Index
- No. of pages:
- © Pergamon 1961
- 1st January 1961
- eBook ISBN: