Description

This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. @introbul:Key Features @bul:* Provides perspectives from both prokaryotic and eukaryotic systems * Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression * Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation * Evaluates experimental procedures for studying mRNA degradation @text:Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists.

Key Features

@introbul:Key Features @bul:* Provides perspectives from both prokaryotic and eukaryotic systems * Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression * Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation * Evaluates experimental procedures for studying mRNA degradation

Table of Contents

Prokaryotes. Mrna Degradation in Prokaryotic Cells: An Overview. The Role of the 3' End in Mrna Stability and Decay. 5'mrna Stabilizers. RNA Processing and Degradation By Rnase E and Rnase K. RNA Processing and Degradation By Rnase III. Translation and Mrna Stability in Bacteria: A Complex Relationship. Eukaryotes. Mrna Degradation in Eukaryotic Cells: An Overview. Hormonal and Developmental Regulation of Mrna Turnover. Control of the Decay of Labile Proto-Oncogene and Cytokine Mrnas. Translationally Coupled Degradation of Tubulin Mrna . Iron Regulation of Tranferrin Receptor Mrna Stability. Degradation of a Non-Polyadenylated Messenge: Histone Mrna Decay. Mrna Turnover in Saccharomyces Cerevisiae. Control of Mrna Degradation in Organelles. Control of Poly(A) Length. Mrna Decay in Cell-Free Systems. Eukaryotic Nucleases and Mrna Turnover. Experimental Approaches to the Study of Mrna Decay. Subject Index.

Details

No. of pages:
517
Language:
English
Copyright:
© 1993
Published:
Imprint:
Academic Press
Print ISBN:
9780120847822
Electronic ISBN:
9780080916521

About the authors

Joel Belasco

Affiliations and Expertise

Harvard Medical School, Boston, Massachusetts, U.S.A.

George Brawerman

Affiliations and Expertise

Tufts University, Boston, Massachusetts, U.S.A.