Control of Energy Metabolism

Control of Energy Metabolism

1st Edition - January 1, 1965

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  • Editors: Britton Chance, Ronald W. Estabrook, John R. Williamson
  • eBook ISBN: 9781483271668

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Control of Energy Metabolism: A Colloquium of the Johnson Research Foundation focuses on the processes, reactions, and approaches involved in the control of energy metabolism. The selection first offers information on the respiratory chain as a model for metabolic control in multi-enzyme systems, dynamics and control in cellular reactions, and computer-based analysis of biochemical data. The text then explores purification and properties of rabbit skeletal muscle phosphofructokinase; multiple forms of heart phosphofructokinase; and mechanisms of inhibition and activation of phosphofructokinase in Novikoff ascites tumor cells. Discussions focus on the properties of purified phosphofructokinase; effect of heart extracts on reactivation of phosphofructokinase; active and inactive forms of phosphofructokinase; and effect of hexose phosphate and adenylic nucleotides on reactivation of phosphofructokinase. The manuscript takes a look at enzyme and metabolite profiles; coordinated stimulation of hexokinase and phosphofructokinase by phosphate in a reconstituted system of glycolysis; control of hexokinase in ascites tumor glycolysis; and cation flux across the mitochondrial membrane as a possible pacemaker of tissue metabolism. The selection is a vital reference for biochemists and researchers interested in the control of energy metabolism.

Table of Contents

  • List of Participants


    Control Characteristics of Enzymes and Enzyme Systems in Vitro

    Opening Remarks

    Introductory Remarks

    I. Theoretical Aspects of Control Properties in Enzyme Systems

    The Respiratory Chain as a Model for Metabolic Control in Multi-Enzyme Systems

    Dynamics and Control in Cellular Reactions

    II. Computer Studies

    Computer Based Analysis of Biochemical Data

    III. Phosphofructokinase: Its Purification, Crystallization, and Kinetic Properties


    Purification and Properties of Rabbit Skeletal Muscle Phosphofructokinase

    Phosphofructokinase from Rabbit Muscle

    Some Properties of Fructose-6-Phosphate Kinase from Rabbit Skeletal Muscle

    Multiple Forms of Heart Phosphofructokinase

    On the Mechanism of Inhibition and Activation of Phosphofructokinase in Novikoff Ascites Tumor Cells

    Control Properties of Phosphofructokinase from Saccharomyces cerevisia

    A Computer Simulation Study of the Metabolic Control Behavior of Phosphofructokinase


    Enzyme Content, Substrate and Cofactor Availability, and Cation Transport as Factors in Metabolic Regulation

    IV. Enzyme Profile Patterns and Reconstituted Systems

    Enzyme and Metabolite Profiles

    Enzyme Profile and Beef Heart Supernatant Fraction


    Coordinated Stimulation of Hexokinase and Phosphofructokinase by Phosphate in a Reconstituted System of Glycolysis

    A Reconstituted Enzyme System

    V. Control in Single-Cellular Systems Due to Pi or ADP Availability

    Control Characteristics of the Adenine Nucleotide System

    ADP and Pi Control in Ascites Tumor Cells

    The Control of Hexokinase in Ascites Tumor Glycolysis

    On the Control of Glycolysis in Novikoff Ascites Tumor Cells

    The Control of Glycolysis in Yeast

    VI. The Role of Cations in Metabolic Control

    Cation Flux Across the Mitochondrial Membrane as a Possible Pacemaker of Tissue Metabolism

    A Role of Sodium and Potassium in Metabolic Control

    The Role of Na+ and K+ on α-Aminoisobutyric Acid Transport in Striated Muscle

    VII. Control Due to Changes of Enzyme Content

    On Transitory and Periodic Systems in Bacteria

    On the Direction of Pyridine Nucleotide Oxidation-Reduction Reactions in Gluconeogenesis and Lipogenesis

    On the Biochemical Imprinting of Metabolic Experience in Liver Cells

    Adaptive Behavior of Citrate Cleavage Enzyme

    Some Aspects of Metabolic Control in the Fertilization Transition of Sea Urchin Eggs

    Control of Metabolism in Intact Tissues

    Introductory Remarks

    VIII. Regulation of Glycolytic Activity in Smooth and Skeletal Muscles

    Activation of Glycolytic Pathway in Muscle

    The Response of the Glycolytic System of Anaerobic Frog Sartorius Muscle to Electrical Stimulation

    Some Biochemical Properties of Intestinal Smooth Muscle in Relation to the Physiological Actions of Epinephrine

    IX. Regulation of Metabolism in Brain

    Effects of Altered Brain Metabolism on the Levels of Krebs Cycle Intermediates

    X. Regulation of Glycolytic Activity in Heart Muscle

    Metabolic Control in the Perfused Rat Heart

    Regulation of Glucose Transport

    Fatty Acid Induced Alterations in Citric Acid Cycle Intermediates

    Bicentennial Lectures on Control of Energy Metabolism

    Energy Transformation in the Generation of Bioelectricity

    Control of Energy Metabolism. Bioenergetics of Muscular Contraction

    Hemoglobin-Free Perfusion of Rat Liver

    Control of Energy Metabolism in Mitochondria


Product details

  • No. of pages: 454
  • Language: English
  • Copyright: © Academic Press 1965
  • Published: January 1, 1965
  • Imprint: Academic Press
  • eBook ISBN: 9781483271668

About the Editors

Britton Chance

Ronald W. Estabrook

John R. Williamson

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