Contemporary Practice in Clinical Chemistry

Contemporary Practice in Clinical Chemistry

4th Edition - June 8, 2020

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  • Editors: William Clarke, Mark Marzinke
  • eBook ISBN: 9780128158333
  • Paperback ISBN: 9780128154991

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Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry.

Key Features

  • Includes enhanced illustration and new and revised color figures
  • Provides improved self-assessment questions and end-of-chapter assessment questions


Fellows and residents of pathology and clinical chemistry, as well as laboratory professionals

Table of Contents

  • 1. Preanalytical Variation
    2. Statistical Methods in Laboratory Medicine
    3. Reference Intervals: Theory and Practice
    4. Method Validation: Finding (and Fixing) the Error of Our Testing Ways
    5. Quality Control
    6. Laboratory Calculations
    7. Spectrophotometry
    8. Chromatography and Electrophoresis
    9. Electrochemistry
    10. Mass Spectrometry
    11. Nuclear Magnetic Resonance Technology and Clinical Applications
    12. Immunoassays
    13. Nucleic Acid Probes Used in the Analysis of DNA
    14. The Polymerase Chain Reaction
    15. Laboratory Automation
    16. Regulatory Issues
    17. Principles of Laboratory Management
    18. Evidence-Based Laboratory Medicine
    19. Harmonization of Results Among Laboratories
    20. Laboratory Information Systems
    21. Point-of-Care Testing
    22. Proteins: Analysis and Interpretation in Serum, Urine, and Cerebrospinal Fluid
    23. Hemoglobin Variant Detection
    24. Hemostasis: The View from the Clinical Chemistry Laboratory
    25. Laboratory Diagnosis of Lipid and Lipoprotein Disorders
    26. Biomarkers for Acute Cardiovascular Diseases and Heart Failure
    27. Laboratory Diagnosis of Liver Disease
    28. Clinical Chemistry of the Gastrointestinal Disorders
    29. Evaluation of Exocrine Pancreatic Function
    30. Carbohydrate Disorders
    31. Laboratory Evaluation of Kidney Function
    32. Blood Gas and Critical Care Testing
    33. Water and Electrolyte Balance
    34. Urinalysis
    35. Disorders of the Anterior and Posterior Pituitary
    36. Laboratory Evaluation of Thyroid Function
    37. Disorders of the Adrenal Cortex and Medulla
    38. Laboratory Testing in Pregnancy and Reproductive Disorders
    39. Tumor Markers
    40. Calcium Biology and Disorders
    41. Vitamins and Trace Elements: Functions and Assessment of Status through Laboratory Testing
    42. Inborn Errors of Metabolism
    43. The Porphyrias: Fundamentals and Laboratory Assessment
    44. Pharmacokinetics for the Practicing Clinical Chemist
    45. Therapeutic Drug Monitoring
    46. Toxicology and the Clinical Laboratory
    47. Pharmacogenetics
    48. Applications of Molecular Techniques in the Clinical Laboratory
    49. Infectious Disease
    50. Pediatric Laboratory Medicine
    51. Diagnostic Body Fluid Testing

Product details

  • No. of pages: 1064
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: June 8, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128158333
  • Paperback ISBN: 9780128154991

About the Editors

William Clarke

Dr. William Clarke is a Professor of Pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. He serves as the director of Clinical Toxicology for Johns Hopkins Hospital, as well as the Point-of-Care Testing Program for Johns Hopkins Medicine.

Affiliations and Expertise

Professor, Department of Pathology, Johns Hopkins University School of Medicine Baltimore, MD, USA

Mark Marzinke

Dr. Mark Marzinke is Associate Professor of Pathology and Medicine at the Johns Hopkins University School of Medicine.Dr. Marzinke serves as the Director of General Chemistry in the Johns Hopkins Hospital Core Laboratories, and is the Director of the Clinical Pharmacology Analytical Laboratory within the Division of Clinical Pharmacology. He is also Co-Director of the HIV Prevention Trials Network Laboratory Center.

Affiliations and Expertise

Associate Professor, Departments of Pathology and Medicine, Johns Hopkins University School of Medicine Baltimore, MD, USA

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