Contemporary Practice in Clinical Chemistry - 4th Edition - ISBN: 9780128154991

Contemporary Practice in Clinical Chemistry

4th Edition

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Editors: William Clarke Mark Marzinke
Paperback ISBN: 9780128154991
Imprint: Academic Press
Published Date: 1st June 2020
Page Count: 825
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Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry.

Key Features

  • Includes enhanced illustration and new and revised color figures
  • Provides improved self-assessment questions and end-of-chapter assessment questions


Fellows and residents of pathology and clinical chemistry, as well as laboratory professionals

Table of Contents

1. Preanalytical Variation
2. Statistical Methods in Laboratory Medicine
3. Reference Intervals: Theory and Practice
4. Method Validation: Finding (and Fixing) the Error of Our Testing Ways
5. Quality Control
6. Laboratory Calculations
7. Spectrophotometry
8. Chromatography and Electrophoresis
9. Electrochemistry
10. Mass Spectrometry
11. Nuclear Magnetic Resonance Technology and Clinical Applications
12. Immunoassays
13. Nucleic Acid Probes Used in the Analysis of DNA
14. The Polymerase Chain Reaction
15. Laboratory Automation
16. Regulatory Issues
17. Principles of Laboratory Management
18. Evidence-Based Laboratory Medicine
19. Harmonization of Results Among Laboratories
20. Laboratory Information Systems
21. Point-of-Care Testing
22. Proteins: Analysis and Interpretation in Serum, Urine, and Cerebrospinal Fluid
23. Hemoglobin Variant Detection
24. Hemostasis: The View from the Clinical Chemistry Laboratory
25. Laboratory Diagnosis of Lipid and Lipoprotein Disorders
26. Biomarkers for Acute Cardiovascular Diseases and Heart Failure
27. Laboratory Diagnosis of Liver Disease
28. Clinical Chemistry of the Gastrointestinal Disorders
29. Evaluation of Exocrine Pancreatic Function
30. Carbohydrate Disorders
31. Laboratory Evaluation of Kidney Function
32. Blood Gas and Critical Care Testing
33. Water and Electrolyte Balance
34. Urinalysis
35. Disorders of the Anterior and Posterior Pituitary
36. Laboratory Evaluation of Thyroid Function
37. Disorders of the Adrenal Cortex and Medulla
38. Laboratory Testing in Pregnancy and Reproductive Disorders
39. Tumor Markers
40. Calcium Biology and Disorders
41. Vitamins and Trace Elements: Functions and Assessment of Status through Laboratory Testing
42. Inborn Errors of Metabolism
43. The Porphyrias: Fundamentals and Laboratory Assessment
44. Pharmacokinetics for the Practicing Clinical Chemist
45. Therapeutic Drug Monitoring
46. Toxicology and the Clinical Laboratory
47. Pharmacogenetics
48. Applications of Molecular Techniques in the Clinical Laboratory
49. Infectious Disease
50. Pediatric Laboratory Medicine
51. Diagnostic Body Fluid Testing


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© Academic Press 2020
1st June 2020
Academic Press
Paperback ISBN:

About the Editor

William Clarke

Dr. William Clarke is an associate professor of pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. He serves as the director of Clinical Toxicology as well as Critical and Point-of-Care Testing Program at The Johns Hopkins Hospital. His team's current projects include qualitative screening for antiretroviral drugs and substances of abuse in various HIV- prevention clinical trials, development and validation of mass spectrometry methods for clinical analysis, and development of clinical assays for use on microfluidic platforms. Dr. Clarke received his B.S. in Chemistry from the University of Nebraska at Kearney and his Ph.D. in Analytical Chemistry from the University of Nebraska-Lincoln, as well as an M.B.A. from the Carey School of Business at Johns Hopkins University. He completed a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins School of Medicine.

Affiliations and Expertise

Associate Professor of Pathology, Division of Clinical Chemistry, Johns Hopkins School of Medicine, Director, Clinical Toxicology, Director, Critical and Point-of-Care Testing The Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USA

Mark Marzinke

Dr. Mark Marzinke is Associate Professor of Pathology and Medicine at the Johns Hopkins University School of Medicine.Dr. Marzinke serves as the Director of General Chemistry in the Johns Hopkins Hospital Core Laboratories, and is the Director of the Clinical Pharmacology Analytical Laboratory within the Division of Clinical Pharmacology. He is also Co-Director of the HIV Prevention Trials Network Laboratory Center. He received his A.B. from the College of the Holy Cross and earned his Ph.D. at the University of Wisconsin-Madison. He completed a fellowship in clinical chemistry at the Johns Hopkins School of Medicine.

Affiliations and Expertise

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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