Contemporary Chemical Approaches for Green and Sustainable Drugs

1st Edition - August 26, 2022

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Editor: Marianna Torok
Paperback ISBN: 9780128222485
eBook ISBN: 9780128232712

View series: Advances in Green and Sustainable Chemistry

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Description

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science.

Key Features

Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues
Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs
Presents individual chapters written by renowned experts with diverse backgrounds
Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Readership

Industrial/academic researchers, process scientists, chemical and bioengineers interested in green and sustainable chemistry, drug discovery and development. Scientists traditionally working outside of green chemistry, such as biochemists and computational chemists, whose work with powerful, advanced tools can significantly contribute to green and sustainable medicinal chemistry. Pharmaceutical industry, government officials (environmental agencies etc.) and managerial level executives in related industries and health care units. It could be used in graduate level education as a textbook, or as a supplemental textbook in medicinal chemistry, green chemistry or environmental chemistry courses

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Using the zebrafish model system to identify the health effects of pharmaceutical pollutants
1. Introduction
2. The zebrafish model system
3. Use of the zebrafish model system in drug discovery
4. Significance of pharmaceutical pollution
5. Use of the zebrafish model system to assess pharmaceutical pollutant toxicity
6. Methods and approaches to assess pharmaceutical pollutant toxicity using the zebrafish model system
7. Future directions for the use of zebrafish in defining pharmaceutical pollutant toxicity
8. Conclusions
Chapter 2. Analysis of pharmaceuticals in the environment
1. Introduction
2. Sources of pharmaceutical pollutants
3. Analytical methods for trace level analysis of water samples
4. Risk management
5. Conclusion
Chapter 3. Leaking of antibiotics in the aquatic environment
1. Introduction
2. How antibiotics are reaching the aquatic environment?
3. Fate of antibiotics in aquatic environment
4. Conclusion
Chapter 4. Advances in drug development with the application of artificial intelligence
1. Machine learning and artificial intelligence in the pharmaceutical industry: perspective
2. Data mining techniques
3. Artificial neural networks (ANN) in property prediction to drug discovery
4. Support vector machines (SVM) in drug discovery and development
5. Conclusion
Chapter 5. Virtual screening techniques in pharmaceutical research
1. Introduction
2. Structure-based drug design (SBDD)
3. Molecular docking
4. Ligand-based drug discovery (LBDD)
5. Summary and perspectives
Chapter 6. In silico modeling of environmental toxicity of drugs
1. Introduction
2. Pharmaceutical ecotoxicity analysis: general considerations
3. Release of pharmaceuticals to the environment
4. Assessment of ecotoxicity of APIs, limitations, and solutions: a data scientist's perspective
5. Current advancement in ecotoxicity modeling of pharmaceuticals
6. Online expert systems for ecotoxicity prediction
7. Conclusion
Chapter 7. Sustainable separations in pharmaceutical manufacturing
1. Introduction
2. Chromatography-based separations
3. Membrane based separations
4. Continuous purification processes
5. Forecasting the future of API separations
Chapter 8. Green synthetic methods in drug discovery and development
1. Introduction
2. Catalysis
3. Nontraditional activation methods and energy efficiency of chemical processes
4. Conclusions
Chapter 9. Characterizing the environmentally benign nature of chemical processes: green chemistry metrics
1. Introduction
2. Emergence of green chemistry
3. Sustainable production of pharmaceuticals and their building blocks: quantitative green metrics to evaluate chemical processes
4. Conclusions
Chapter 10. Green chemistry approaches to drugs that treat epidemic and pandemic diseases
1. Introduction
2. Antibacterial drugs
3. Drugs to treat malaria
4. Drugs to treat HIV/AIDS
5. Antivirals to treat COVID-19
6. Conclusions
Chapter 11. Dynamic effects of organic molecules for drug delivery in micelles
1. Introduction
2. Drug solubilization through drug delivery vehicles
3. Molecular drug delivery by organized self-assemblies
4. Conclusion
Chapter 12. Antibody-drug conjugates for targeted delivery
1. Introduction
2. Composition
3. Antibody-drug conjugation
4. Physical stability of antibody-drug conjugates
5. Chemical stability of antibody-drug conjugate
6. Formulation development of antibody-drug conjugate
7. Future aspects of ADCs
Chapter 13. Toward the green synthesis of peptides and peptidic drugs
1. Peptides and peptide synthesis: the formation of peptide bond
2. Improvements in the solid-phase method
3. Novel methods for dissolving limitations of SPPS
4. Large-scale peptide synthesis methods
5. Green chemistry aspects of peptide synthesis
6. Summary
Chapter 14. The multitarget approach as a green tool in medicinal chemistry
1. Introduction
2. The green impact of multitarget drug discovery
3. Multitarget lead generation—screening-versus knowledge-based approaches
4. Selected case studies with multitarget focus
5. Challenges and limitations in multitarget drug design and development
6. Conclusions
Chapter 15. Directed evolution: a new powerful tool in drug development
1. Introduction
2. Methods in directed evolution
3. Application of directed evolution in drug development
4. Perspectives
Chapter 16. Conventional and advanced treatment methods for the removal of pharmaceuticals and related compounds in wastewater
1. Introduction
2. Overview of conventional wastewater treatment
3. Effectiveness of conventional wastewater treatment in removing pharmaceuticals
4. Advanced treatment processes for the removal of pharmaceuticals from municipal wastewater
5. Case Study #1: San Bernardino municipal water department
6. Case Study #2: the Orange County Sanitation District, Fountain Valley, CA
7. Conclusion
Index

Product details

No. of pages: 566
Language: English
Published: August 26, 2022
Imprint: Elsevier
Paperback ISBN: 9780128222485
eBook ISBN: 9780128232712

About the Editor

Marianna Torok

Dr Marianna Török complete her studies in Physical Chemistry and Biochemistry at the University of Szeged (Hungary), University of Southern California Los Angeles (USA) and Massachusetts Institute of Technology (USA). She is an associate professor at the Department of Chemistry, University of Massachusetts Boston (USA), a public university strongly committed to Green Chemistry education and research, and the first school to offer a doctoral degree via the PhD in Chemistry/Green Chemistry Track. Her research interest includes the interconnection of Medicinal Chemistry and Green Chemistry, and she is a co-author of several reviews and research articles in this field

Affiliations and Expertise

Associate Professor, Department of Chemistry, University of Massachusetts, Boston, USA

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