Contemporary Chemical Approaches for Green and Sustainable Drugs

Contemporary Chemical Approaches for Green and Sustainable Drugs

1st Edition - June 1, 2022
  • Editor: Marianna Torok
  • Paperback ISBN: 9780128222485

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Description

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science.

Key Features

  • Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues
  • Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs
  • Presents individual chapters written by renowned experts with diverse backgrounds
  • Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Readership

Industrial/academic researchers, process scientists, chemical and bioengineers interested in green and sustainable chemistry, drug discovery and development. Scientists traditionally working outside of green chemistry, such as biochemists and computational chemists, whose work with powerful, advanced tools can significantly contribute to green and sustainable medicinal chemistry. Pharmaceutical industry, government officials (environmental agencies etc.) and managerial level executives in related industries and health care units. It could be used in graduate level education as a textbook, or as a supplemental textbook in medicinal chemistry, green chemistry or environmental chemistry courses

Table of Contents

  • Part I. Health Concerns, Risk Assessment and Environmental Monitoring of Pharmaceutical Pollutants
    1. Types of Pharmaceutical Pollutants and their Environmental Risk Assessment
    Marlene Ågerstrand Stockholm University
    2. Novel Analytical Methods for Environmental Monitoring
    Alexandros Asimakopoulos, Norwegian University of Science and Technology
    3. Antibiotic Resistance and Preventative Measures
    Joakim Larsson, University of Gothenburg
    4. Ecotoxicogenomics for Understanding the Effects of Pharmaceutical Pollution
    Helen C. Poynton, University of Massachusetts Boston
    5. Drugs and Drug Byproducts as Endocrine Disruptors
    Shelley R. Ehrlich, Cincinnati Children’s Hospital
    6. Accumulation of Drug Residues in Food
    Guang-Guo Ying, South China Normal University

    Part II. Computational Tools of Green Drug Design
    7. Data Mining and Machine Learning in Drug Discovery and Development
    Russ B. Altman, Stanford University
    8. Virtual Screening Techniques in Pharmaceutical Research

    Justine C Williams, Stanley Opare, Senthil Kumar Sugadoss, Aravindhan Ganesan, Subha Kalyaanamoorthy, University of Waterloo
    9. In Silico Toxicology
    Vladimir Bajic, King Abdullah University of Science and Technology
    10. Quantum Chemistry for the Environment
    Jonathan Stevens, University of Detroit, Mercy

    Part III. Green Sourcing of Drugs and Drug Candidates
    11. Renewable Resources
    James H Clark, University of York, UK
    12. Sustainable Separations
    Gyorgy Szekely, King Abdullah University of Science and Technology
    13. Green Solvents for Drug Synthesis
    Jason Hallett, Imperial College London
    14. Green Synthetic Methods in Drug Discovery and Development
    Bela Torok, University of Massachusetts, Boston
    15. Green Manufacturing of Pharmaceuticals
    Berkeley W. Cue, BWC Pharma Consulting, LLC,and University of Massachusetts Boston
    16. Green Metrics of Drug Synthesis
    Roger A. Sheldon, University of the Witwatersrand

    Part IV. New Chemical Directions to Reducing Drugs and their Byproducts in the Environment
    17. Sustainable Nanotechnology
    Rajender S Varma, U.S. Environmental Protection Agency
    18. Novel Water Treatment Technologies
    Navid Saleh, University of Texas, Austin
    19. Green Peptide-based Drugs
    Marianna Torok, University of Massachusetts, Boston
    20. Multi-Target Approaches in Medicinal Chemistry
    Maria Laura Bolognesi, University of Bologna
    21. Directed Evolution for the Production of Pharmaceuticals
    Ulrich Schwaneberg, RWTH Aachen University
    22. Oligonucleotide Therapeutics
    Anastasia Khvorova, UMass Medical School
    23. Bioorthogonal Chemistry
    Binghe Wang, Georgia State University
    24. Antibody-Drug Conjugates for Targeted Delivery
    David R. Spring, University of Cambridge

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: June 1, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780128222485

About the Editor

Marianna Torok

Dr Marianna Török complete her studies in Physical Chemistry and Biochemistry at the University of Szeged (Hungary), University of Southern California Los Angeles (USA) and Massachusetts Institute of Technology (USA). She is an associate professor at the Department of Chemistry, University of Massachusetts Boston (USA), a public university strongly committed to Green Chemistry education and research, and the first school to offer a doctoral degree via the PhD in Chemistry/Green Chemistry Track. Her research interest includes the interconnection of Medicinal Chemistry and Green Chemistry, and she is a co-author of several reviews and research articles in this field

Affiliations and Expertise

Associate Professor, Department of Chemistry, University of Massachusetts, Boston, USA