Contemporary Challenges in Sudden Cardiac Death, An Issue of Cardiac Electrophysiology Clinics

Contemporary Challenges in Sudden Cardiac Death, An Issue of Cardiac Electrophysiology Clinics

1st Edition - November 30, 2017

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  • Authors: Mohammad Shenasa, N. A. Estes II, Gordon Tomaselli
  • eBook ISBN: 9780323552691
  • Hardcover ISBN: 9780323552684

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Description

This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa, N. A. Mark Estes III, and Gordon F. Tomaselli, will cover Contemporary Challenges in Sudden Cardiac Death. Topics covered in this issue include Pathophysiology; Basic electrophysiological mechanism; Channelopathy and Myopathy as causes of sudden cardiac death; Public access to defibrillation; Sudden cardiac death in children adolescence; Sudden cardiac death in specific cardiomyopathies; Ventricular arrhythmias and sudden cardiac death; lessons learned from cardiac implantable rhythm devices; future directions, and more.

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Forthcoming Issues
  • Foreword
  • Preface
  • Sudden Cardiac Death: Interface Between Pathophysiology and Epidemiology
  • Key points
  • Incidence of sudden cardiac arrest
  • Causes and mechanisms of cardiac arrest
  • Mechanistic targets derived from epidemiologic subdivisions
  • Mechanisms and pathophysiology of sudden cardiac arrest in coronary heart disease
  • Transition from myocardial instability to lethal tachyarrhythmias
  • Asystolic arrest
  • Pulseless electrical activity
  • Basic Electrophysiologic Mechanisms of Sudden Cardiac Death Caused by Acute Myocardial Ischemia and Infarction
  • Key points
  • Introduction
  • The acute phase of myocardial ischemia and infarction
  • Channelopathies as Causes of Sudden Cardiac Death
  • Key points
  • Long QT syndrome
  • Catecholaminergic polymorphic ventricular tachycardia
  • Brugada syndrome
  • Public Access Defibrillation: Is This Making Any Difference? Controversial Issues in Resuscitation from Cardiac Arrest
  • Key points
  • Introduction
  • Launching of bystander use of automatic defibrillators: public access defibrillation
  • Equipping of police vehicles and training of police in the use of automated external defibrillators
  • Community-based studies of use and outcome
  • Concentration of shockable cardiac arrests in public locations
  • Contemporary use of automated external defibrillators in cardiac arrests witnessed in public locations
  • Opportunities for further improvement in use of automated external defibrillators in all cardiac arrests occurring in public locations
  • Circulatory phase of cardiac resuscitation in relation to shock and use of automated external defibrillators
  • Controversial and noncontroversial aspects of cardiopulmonary resuscitation
  • Summary
  • Sudden Cardiac Death During Sports Activities in the General Population
  • Key points
  • Sports activity: conclusively beneficial for long-term sudden cardiac death risk
  • Sudden death in the young competitive athlete: the apparent part of the iceberg
  • Sudden cardiac death among recreational sports participants: the majority of sports-related sudden cardiac death
  • Sports-related sudden cardiac death presents with highly homogenous characteristics
  • How to tackle sports-related sudden cardiac death?
  • Summary
  • Sudden Cardiac Death in Children and Adolescents
  • Key points
  • Introduction
  • Epidemiology
  • Etiologies
  • Autopsy findings
  • Genetic testing
  • Cascade screening
  • Community screening
  • Special populations
  • Treatment
  • Summary
  • Sudden Cardiac Death in Genetic Cardiomyopathies
  • Key points
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Arrhythmogenic right ventricular cardiomyopathy
  • Electrocardiographic Markers of Sudden Cardiac Death (Including Left Ventricular Hypertrophy)
  • Key points
  • Main causes of sudden cardiac death
  • Electrocardiographic markers of sudden cardiac death: role of the electrocardiogram as a part of a risk stratification of sudden cardiac death
  • Risk prediction of ventricular arrhythmias after myocardial infarction
  • Electrocardiographic markers of sudden cardiac death: depolarization abnormalities
  • Presence of ventricular late potentials using high-resolution or signal-averaged electrocardiography
  • Summary
  • Prediction and Prevention of Sudden Cardiac Death
  • Key points
  • Introduction
  • Ischemic heart disease
  • Nonischemic cardiomyopathy
  • Risk stratification of sudden cardiac death in inherited channelopathies
  • Sudden cardiac death in the athlete
  • Summary
  • Role of Cardiac Imaging in Evaluating Risk for Sudden Cardiac Death
  • Key points
  • Introduction
  • Concepts in risk stratification
  • Cardiac imaging and sudden cardiac death pathophysiology
  • Evaluation of arrhythmic substrates
  • Myocardial sympathetic denervation and the risk of sudden cardiac death
  • Summary
  • Biomarkers to Predict Cardiovascular Death
  • Key points
  • Biomarkers of cardiovascular death in the general population
  • Biomarkers of cardiovascular death in coronary artery disease
  • Biomarkers of sudden cardiac death in heart failure
  • Future directions
  • Summary
  • Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death
  • Key points
  • Introduction
  • Anatomy
  • Autonomic nervous system and cardiac pathophysiology
  • Neural remodeling in the setting of myocardial infarction
  • Neuraxial modulation to reduce risk of sudden cardiac death
  • Summary
  • Sudden Cardiac Death in Ischemic Heart Disease: Pathophysiology and Risk Stratification
  • Key points
  • Introduction
  • Pathophysiology of sudden cardiac death in ischemic heart disease
  • Remodeling after myocardial infarction and sudden cardiac death
  • Current risk stratification of sudden cardiac death in ischemic heart disease
  • Surrogate measures of conduction disorders
  • Imaging and quantification of myocardial scar
  • Surrogate measures of dispersion of repolarization
  • Surrogate measures of autonomic function
  • Imaging of cardiac sympathetic innervation
  • Ambulatory monitoring
  • Electrophysiologic study
  • Biomarkers
  • Genomics
  • Noninvasive clinical risk variables
  • Summary
  • Ventricular Arrhythmias and Sudden Cardiac Death
  • Key points
  • Introduction
  • Ischemic cardiomyopathy
  • Nonischemic cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Arrhythmogenic right ventricular cardiomyopathy
  • Repaired congenital heart disease
  • Brugada syndrome
  • Long QT syndrome
  • Short QT syndrome
  • Catecholaminergic polymorphic ventricular tachycardia
  • Early repolarization patterns
  • Idiopathic ventricular tachycardia
  • Future directions
  • Summary
  • Heart Failure and Sudden Cardiac Death
  • Key points
  • Introduction
  • Risk stratification: beyond the left ventricular ejection fraction
  • MRI: delayed enhancement: metaiodobenzylguanidine
  • Medical therapies for reduction of mortality in patients with heart failure
  • Device and ablative strategies for reduction of mortality in patients with heart failure
  • Wearable cardioverter defibrillator
  • Antiarrhythmic drugs and ablation for ventricular tachycardia in heart patients with failure
  • Nonischemic cardiomyopathies
  • End-of-life care
  • Sudden Cardiac Death in Acute Coronary Syndromes
  • Key points
  • Introduction
  • Sudden cardiac arrest as initial manifestation of an acute coronary syndrome
  • In-hospital complex ventricular arrhythmias
  • Prognostic significance of in-hospital complex ventricular arrhythmias
  • Acute treatment of ventricular tachyarrhythmias in the setting of acute coronary syndromes
  • Other measures for management of ventricular tachyarrhythmias in patients with acute coronary syndromes
  • Catheter ablation in the acute setting
  • Implantable cardioverter-defibrillator
  • Summary
  • Neuromuscular Disease: Cardiac Manifestations and Sudden Death Risk
  • Key points
  • Introduction and general principles
  • Muscular dystrophies, cardiac arrhythmias, and sudden cardiac death
  • Summary/future directions
  • Sudden Cardiac Death: Lessons Learned from Cardiac Implantable Rhythm Devices
  • Key points
  • Introduction
  • Establishment of implantable cardioverter–defibrillator devices
  • The negative lessons
  • Summary
  • Primary Prevention Implantable Cardiac Defibrillator Trials: What Have We Learned?
  • Key points
  • Introduction
  • Primary prevention implantable cardioverter-defibrillators in ischemic cardiomyopathy, 1990s
  • Primary prevention implantable cardioverter-defibrillators in ischemic cardiomyopathy, 2000s
  • Primary prevention implantable cardioverter-defibrillators in nonischemic cardiomyopathy
  • Evidence that benefit from implantable cardioverter-defibrillators is not uniformly distributed in tested populations
  • Summary
  • The Subcutaneous Defibrillator
  • Key points
  • Introduction
  • The subcutaneous defibrillator
  • Subcutaneous implantable cardioverter-defibrillator efficacy
  • Procedural complications
  • Inappropriate shocks
  • Subcutaneous implantable cardioverter-defibrillator limitations
  • Comparison with transvenous implantable cardioverter-defibrillator
  • Summary
  • Future Directions: Management of Sudden Cardiac Death
  • Key points
  • Introduction
  • National cardiac arrest registry
  • Fostering a culture of action
  • Optimizing emergency medical service system capabilities and performance
  • Optimizing hospital performance
  • Accelerating research
  • Structured collaboration
  • Summary

Product details

  • Language: English
  • Copyright: © Elsevier 2017
  • Published: November 30, 2017
  • Imprint: Elsevier
  • eBook ISBN: 9780323552691
  • Hardcover ISBN: 9780323552684

About the Authors

Mohammad Shenasa

Affiliations and Expertise

Department of Cardiovascular Services, O’Conner Hospital, Heart & Rhythm Medical Group, San Jose CA

N. A. Estes II

Affiliations and Expertise

Tufts University School of Medicine

Gordon Tomaselli

Affiliations and Expertise

Executive Vice President; Chief Academic Officer; Dean Montefiore Medicine; Professor, Department of Medicine Einstein College of Medicine, Yeshiva University, Bronx, New York

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