Conceptual Breakthroughs in The Evolutionary Biology of Aging

Conceptual Breakthroughs in The Evolutionary Biology of Aging

1st Edition - December 1, 2022

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  • Authors: Kenneth Arnold, Michael Rose
  • Paperback ISBN: 9780128215456

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Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field’s breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field.The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures.

Key Features

  • Reviews cell-molecular theories of aging in the light of evolutionary biology
  • Offers an evolutionary analysis of prospects for mitigating aging not commonly discussed within private and public sectors
  • Provides readers with a radically different perspective on contemporary biological gerontology, specifically through the lens of evolutionary biology


Researchers in evolutionary biology, human evolution studies, and aging studies. Advanced undergraduate and graduate students in evolutionary biology studies

Table of Contents

  • 1. Natural Selection is the Ultimate Determinant of Aging
    2. Basic Mathematics of Selection with Age-Structure and Matching Lab Data
    3. First Explanation of Aging by Age-Specific Patterns of Selection
    4. First Proposal of the General Idea of Declining Force of Natural Selection
    5. Hypotheses for the Evolutionary Genetics of Aging
    6. Absence of a Lansing effect in Inbred Drosophila
    7. Presence of Aging in a Fish with Continued Adult Growth
    8. Mathematical Derivation of the Forces of Natural Selection
    9. Falsification of the Somatic Mutation Theory
    10. Falsification of the Translation Error Catastrophe Theory
    11. Proposal of Experimental Designs to Test Evolutionary Theories of Aging
    12. Accidental Evolutionary Postponement of Aging
    13. Experimental Evolution of Accelerated Aging in Tribolium
    14. Development of Evolutionary Genetics in Age-Structured Populations
    15. Application of Charlesworth’s Theory to the Evolution of Aging
    16. Full Development of Evolutionary Genetic Theory for Aging
    17. Quantitative Genetics tests of Hypotheses for the Evolution of Aging
    18. Reproducible Mitigation of Aging by Postponing the Decline in Forces of Natural Selection
    19. Discovery and Characterization of Caenorhabditis elegans Mutants with Extended Lifespan
    20. Further Mathematical Characterization of Evolution with Antagonistic Pleiotropy
    21. Genetic Covariation is Shifted to Positive Values by Inbreeding
    22. Additional Experiments Supporting Antagonistic Pleiotropy
    23. Direct Demonstration of Non-Aging in Fissile Species
    24. Genotype-by-Environment Interaction Shown for Aging
    25. Evolutionary Physiology of Aging
    26. Accelerated Senescence Explained in terms of Inbreeding Depression
    27. Reverse Evolution of Aging
    28. Genetic Analysis of Aging in Males
    29. Quantitative Genetic Analysis of How Many Genes Determine Aging
    30. Evidence for Senescence in the Wild
    31. Molecular Genetic Variation at Selected Loci in the Evolution of Aging
    32. The Evolutionary Logic of Extending Lifespan by Dietary Restriction
    33. Selection for Stress Resistance Increases Lifespan
    34. In Late Adult Life, Mortality Rates Stop Increasing
    35. Evolution of Increased Longevity Among Mammals in the Wild and the Lab
    36. Evolutionary Physiology of Dietary Restriction
    37. Genetic Association between Dauer Metabolic Arrest and Increased Lifespan
    38. Experimental Evolution of Aging is Connected to Development
    39. Evidence for Mutation Accumulation affecting Virility Aging
    40. Deep Physiological Research into the Evolution of Aging Supports Organismal Mechanisms
    41. Late-life Mortality Plateaus Explained using Evolutionary Theory
    42. Falsification of Lifelong Heterogeneity Models for the Cessation of Aging
    43. Discovery of Drosophila Mutants Sometimes Increasing Longevity
    44. Nematode Longevity Mutants show Antagonistic Pleiotropy
    45. Experimental Evolution of Life-History fits the Evolutionary Analysis of Late Life
    46. Breakdown in Correlations between Stress Resistance and Aging
    47. Alternative Indicators for the Forces of Natural Selection Proposed
    48. Development of Demographic Models that Separate Aging from Dying
    49. Genome-wide Sequencing of Experimentally Evolved Aging Reveals Many Genetic Sites
    50. Studying the Evolutionary Origins of Aging in Bacteria
    51. Evolutionary Transcriptomics also reveal Complex Physiology of Aging
    52. Late Life is Physiologically Different from Aging
    53. Genomic Studies of Centenarians Having Low Scientific Power
    54. Evolutionary Genetic Effects Produce Two Evolutionary Biologies of Aging
    55. Experimental Evolution can Produce Non-Aging Young Adults
    56. The Heart is Implicated in the Evolution of Aging
    57. Machine Learning Unpacks the Genomics of the Evolution of Aging

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128215456

About the Authors

Kenneth Arnold

Kenneth R. Arnold is a Graduate Researcher at the University of California at Irvine, working with Dr. Michael Rose in the Department of Ecology and Evolutionary Biology. He is also the Laboratory Stock Manager in the Laboratory of Dr. Michael Rose and Dr. Laurence Mueller at UCI. His studies and area of expertise deal with evolutionary biology and genomic trajectories

Affiliations and Expertise

Graduate Researcher, University of California at Irvine, USA

Michael Rose

Michael Rose is a Distinguished Professor of Ecology and Evolutionary Biology at the University of California at Irvine. Since 2006, he also serves as the Director of the Network for Experimental Research on Evolution. Dr. Rose is widely recognized as a leading researcher in evolutionary biology, specifically the effects of this on aging humans; he published a groundbreaking book on this subject in 1991. In addition to this book publication, Dr. Rose has written hundreds of academic journal papers on evolution, evolutionary biology, and the evolution of aging.

Affiliations and Expertise

Professor of Ecology and Evolutionary Biology, University of California at Irvine, USA

About the Series Editor

John Avise

John C. Avise is a Distinguished Professor at the University of California at Irvine, and an elected member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the American Philosophical Society. His research utilizes molecular markers to study the ecology and evolution of wild animals on topics ranging from genetic parentage and mating behaviors to gene flow, hybridization, phylogeography, speciation, and phylogeny. He has published more than 340 scientific articles and 25 books on a wide variety of evolutionary genetic topics.

Affiliations and Expertise

Professor, Department of Ecology and Evolutionary Biology, University of California at Irvine, CA, USA

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