Conceptual Breakthroughs in The Evolutionary Biology of Aging

1st Edition - July 10, 2023
Authors: Kenneth R. Arnold, Michael R. Rose
Editor: John C. Avise
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 5 4 5 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 5 4 6 - 3

Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakt… Read more

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Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field’s breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field.

The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures.

Cover image
Title page
Table of Contents
Copyright
Dedication
Foreword from the Series Editor, John C. Avise
Chapter One. Introduction
Chapter Two. 384–322B.C: The first biologist on aging
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Three. 1645: A tale of two Bacons
The standard paradigm
The conceptual breakthrough
Impact: 4
Chapter Four. 1881: Natural selection is the ultimate determinant of aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Five. 1922: Early laboratory experiments on demography
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Six. 1928: Basic mathematics of selection with age-structure
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Seven. 1930: First explanation of aging by age-specific patterns of selection
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Eight. 1941: First proposal of the general idea of declining force of natural selection
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Nine. 1946–57: Verbal hypotheses for the evolutionary genetics of aging
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Ten. 1953: Absence of a Lansing effect in inbred Drosophila
The standard paradigm
The conceptual breakthrough
Impact: 5
Chapter Eleven. 1961: Presence of aging in a fish with continued adult growth
The standard paradigm
The conceptual breakthrough
Impact: 4
Chapter Twelve. 1966: Mathematical derivation of the forces of natural selection
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Thirteen. 1960s: Falsification of the somatic mutation theory
The standard paradigm
The conceptual breakthrough
Impact: 4
Chapter Fourteen. 1960s: Falsification of the translation error catastrophe theory
The standard paradigm
The conceptual breakthrough
Impact: 5
Chapter Fifteen. 1968: Proposal of experimental designs to test evolutionary theories of aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Sixteen. 1968: Accidental evolutionary postponement of aging
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Seventeen. 1970: Experimental evolution of accelerated aging in Tribolium
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Eighteen. 1970–74: Development of evolutionary genetics of age-structured populations
The standard paradigm
The conceptual breakthrough
Impact: 10
Chapter Nineteen. 1975: Application of Charlesworth's theory to the evolution of aging
The standard paradigm
The conceptual breakthrough
Impact: 10
Chapter Twenty. 1980: Full development of evolutionary genetic theory for aging
The standard paradigm
The conceptual breakthrough
Impact: 10
Chapter Twenty One. 1980–81: Quantitative genetic tests of hypotheses for the evolution of aging
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Twenty Two. 1980–84: Mitigation of aging by postponing the decline in forces of natural selection
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Twenty Three. 1977–1988: Characterization of Caenorhabditis elegans mutants with extended lifespan
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Twenty four. 1982–85: Further mathematical characterization of evolution with antagonistic pleiotropy
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Twenty Five. 1984: Genetic covariation is shifted to positive values by inbreeding
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Twenty Six. 1984: Direct demonstration of nonaging in fissile species
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Twenty seven. 1989: Additional experiments support antagonistic pleiotropy
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Twenty eight. 1985: Genotype-by-environment interaction shown for aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Twenty nine. 1985–onward: Evolutionary physiology of aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Thirty. 1987: Accelerated senescence explained in terms of mutation accumulation with inbreeding depression
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Thirty one. 1988: Reverse evolution of aging
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Thirty two. 1985–88: Genetic analysis of aging in males
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Thirty three. 1987–1991: Quantitative genetic analysis of how many genes determine aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Thirty four. 1988: Evidence for senescence in the wild
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Thirty five. 1989–onward: Molecular genetic variation at selected loci in the evolution of aging
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Thirty six. 1988–89: The evolutionary logic of extending lifespan by dietary restriction
The standard paradigm
The conceptual breakthrough
Impact: 4
Chapter Thirty seven. 1992: Selection for stress resistance increases lifespan
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Thirty eight. 1992: In late adult life, mortality rates stop increasing
The standard paradigm
The conceptual breakthrough
Impact: 10
Chapter Thirty nine. 1993–1995: Evolution of increased longevity among mammals, in the wild and the lab
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Forty. 1993: Evolutionary physiology of dietary restriction
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Forty one. 1993: Genetic association between dauer metabolic arrest and increased lifespan
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Forty two. 1992–95: Experimental evolution of aging is connected to development
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Forty three. 1994–96: Evidence for mutation accumulation affecting virility and aging
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Forty four. 1996–98: Physiological research on evolution of aging supports organismal mechanisms
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Forty five. 1996: Late-life mortality plateaus explained using evolutionary theory
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Forty six. 1998–2003: Falsification of lifelong heterogeneity models for the cessation of aging
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Forty seven. 1998–2000: Discovery of Drosophila mutants that sometimes increase longevity
The standard paradigm
The conceptual breakthrough
Impact: 3
Chapter Forty eight. 1999–2004: Nematode longevity mutants show antagonistic pleiotropy
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Forty nine. 2002–06: Evolution of life-history fits evolutionary analysis of late life
The standard paradigm
The conceptual breakthrough
Impact: 10
Chapter Fifty. 2003–2005: Breakdown in correlations between stress resistance and aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Fifty one. 2007–11: Development of demographic models that separate aging from dying
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Fifty two. 2010: Studying the evolutionary origins of aging in bacteria
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Fifty three. 2010: Genome-wide sequencing of evolved aging reveals many sites
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Fifty four. 2011–19: Evolutionary transcriptomics also reveal complex physiology of aging
The standard paradigm
The conceptual breakthrough
Impact: 9
Chapter Fifty five. 2012: Late life is physiologically different from aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Fifty six. 2014: Genomic studies of centenarians have low scientific power
The standard paradigm
The conceptual breakthrough
Impact: 3
Chapter Fifty seven. 2015: Evolutionary genetic effects produce two evolutionary biologies of aging
The standard paradigm
The conceptual breakthrough
Impact: 6
Chapter Fifty eight. 2016: Experimental evolution can produce nonaging young adults
The standard paradigm
The conceptual breakthrough
Impact: 8
Chapter Fifty nine. 2017: The heart is implicated in the evolution of aging
The standard paradigm
The conceptual breakthrough
Impact: 7
Chapter Sixty. 2020: Evolutionary adaptation to diet and its impact on healthspan
The standard paradigm
The conceptual breakthrough
Impact: 9
Conclusion
Glossary
Author Index
Index

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John C. Avise

Kenneth R. Arnold

Michael R. Rose