Computational Methods in Molecular Biology, Volume 32

1st Edition

Editors: S.L. Salzberg D.B. Searls S. Kasif
Hardcover ISBN: 9780444828750
eBook ISBN: 9780080860930
Imprint: Elsevier Science
Published Date: 19th June 1998
Page Count: 368
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Table of Contents

Preface. 1. Grand challenges in computational biology (D.B. Searls). 2. A tutorial introduction to computation for biologists (S.L. Salzberg). 3. An introduction to biological sequence analysis (K.H. Fasman, S.L. Salzberg). 4. An introduction to hidden Markov models for biological sequences (A. Krogh). 5. Case-based reasoning driven gene annotation (G.C. Overton, J. Haas). 6. Classification-based molecular sequence analysis (D.J. States, W.C. Reisdorf, Jr.) 7. Computational gene prediction using neural networks and similarity search (Y. Xu, E.C. Uberbacher). 8. Modeling dependencies in pre-mRNA splicing signals (C.B. Burge). 9. Evolutionary approaches to computational biology (R.J. Parsons). 10. Decision trees and Markov chains for gene finding (S.L. Salzberg). 11. Statistical analysis of protein structures: using environmental features for multiple purposes (L. Wei, J.T. Chang, R.B. Altman). 12. Analysis and algorithms for protein sequence-structure alignment (R.H. Lathrop et al.). 13. THREADER: protein sequence threading by double dynamic programming (D. Jones). 14. From computer vision to protein structure and association (H.J. Wolfson, R. Nussinov). 15. Modeling biological data and structure with probabilistic networks (S. Kasif, A.L. Delcher). Appendix A: Software and databases for computational biology on the Internet. Appendix B: Suggestions for further reading in computational biology.


Computational biology is a rapidly expanding field, and the number and variety of computational methods used for DNA and protein sequence analysis is growing every day. These algorithms are extremely valuable to biotechnology companies and to researchers and teachers in universities.
This book explains the latest computer technology for analyzing DNA, RNA, and protein sequences. Clear and easy to follow, designed specifically for the non-computer scientist, it will help biologists make better choices on which algorithm to use. New techniques and demonstrations are elucidated, as are state-of-the-art problems, and more advanced material on the latest algorithms.
The primary audience for this volume are molecular biologists working either in biotechnology companies or academic research environments, individual researchers and the institutions they work for, and students. Any biologist who relies on computers should want this book.
A secondary audience will be computer scientists developing techniques with applications in biology.
An excellent reference for leading techniques, it will also help introduce computer scientists to the biology problems. This is an outstanding work which will be ideal for the increasing number of scientists moving into computational biology.


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@qu:...Clear and easy to follow, designed specifically for the non computer scientist, it will help biologists make better choices on which algorithm to use. @source:Documentation @qu:(...)an impressive selection of papers, all authored by leading bioinformaticians. The volume covers this large multi-disciplinary field of research quite well, from sequence alignment, pattern discovery, gene finding to protein structure. @source:Trends in Genetics @from:(A. Lloyd, INCBI, the Irish EMBnet Node) @qu:The editors have decided to choose authors who have contributed effective software to the community. This horse's mouth approach has the advantage of getting really authoritative explanations of the problems and their solutions.(...)significant effort has been made to introduce each topic in general terms before ploughing deeper into the structure, constraints and functions of biological molecules. @source:Briefings In Bioinformatics, Vol. 1, No. 3

About the Editors

S.L. Salzberg Editor

Affiliations and Expertise

The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA, and, Department of Computer Science, 225 New Engineering Building, Johns Hopkins University, Baltimore, MD 21218, USA

D.B. Searls Editor

Affiliations and Expertise

Group Director for Bioinformatics, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406, USA

S. Kasif Editor

Affiliations and Expertise

Dept. of Electrical Engineering and Computer Science, University of Illinois at Chicago, 851 South Morgan Street - 1120 SEO, Chicago, IL 60607-7053, USA