Computational Methods in Molecular Biology

Computational Methods in Molecular Biology

1st Edition - June 19, 1998

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  • Editors: S.L. Salzberg, D.B. Searls, S. Kasif
  • eBook ISBN: 9780080860930

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Computational biology is a rapidly expanding field, and the number and variety of computational methods used for DNA and protein sequence analysis is growing every day. These algorithms are extremely valuable to biotechnology companies and to researchers and teachers in universities.This book explains the latest computer technology for analyzing DNA, RNA, and protein sequences. Clear and easy to follow, designed specifically for the non-computer scientist, it will help biologists make better choices on which algorithm to use. New techniques and demonstrations are elucidated, as are state-of-the-art problems, and more advanced material on the latest algorithms.The primary audience for this volume are molecular biologists working either in biotechnology companies or academic research environments, individual researchers and the institutions they work for, and students. Any biologist who relies on computers should want this book.A secondary audience will be computer scientists developing techniques with applications in biology.An excellent reference for leading techniques, it will also help introduce computer scientists to the biology problems. This is an outstanding work which will be ideal for the increasing number of scientists moving into computational biology.

Table of Contents

  • Preface. 1. Grand challenges in computational biology (D.B. Searls). 2. A tutorial introduction to computation for biologists (S.L. Salzberg). 3. An introduction to biological sequence analysis (K.H. Fasman, S.L. Salzberg). 4. An introduction to hidden Markov models for biological sequences (A. Krogh). 5. Case-based reasoning driven gene annotation (G.C. Overton, J. Haas). 6. Classification-based molecular sequence analysis (D.J. States, W.C. Reisdorf, Jr.) 7. Computational gene prediction using neural networks and similarity search (Y. Xu, E.C. Uberbacher). 8. Modeling dependencies in pre-mRNA splicing signals (C.B. Burge). 9. Evolutionary approaches to computational biology (R.J. Parsons). 10. Decision trees and Markov chains for gene finding (S.L. Salzberg). 11. Statistical analysis of protein structures: using environmental features for multiple purposes (L. Wei, J.T. Chang, R.B. Altman). 12. Analysis and algorithms for protein sequence-structure alignment (R.H. Lathrop et al.). 13. THREADER: protein sequence threading by double dynamic programming (D. Jones). 14. From computer vision to protein structure and association (H.J. Wolfson, R. Nussinov). 15. Modeling biological data and structure with probabilistic networks (S. Kasif, A.L. Delcher). Appendix A: Software and databases for computational biology on the Internet. Appendix B: Suggestions for further reading in computational biology.

Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Elsevier Science 1998
  • Published: June 19, 1998
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080860930

About the Editors

S.L. Salzberg

Affiliations and Expertise

The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA, and, Department of Computer Science, 225 New Engineering Building, Johns Hopkins University, Baltimore, MD 21218, USA

D.B. Searls

Affiliations and Expertise

Group Director for Bioinformatics, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406, USA

S. Kasif

Affiliations and Expertise

Dept. of Electrical Engineering and Computer Science, University of Illinois at Chicago, 851 South Morgan Street - 1120 SEO, Chicago, IL 60607-7053, USA

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