Volume 70. Co-Transport Systems

Current Topics In Membranes

Dedication

Contributors

Preface

Previous Volumes In Series

Chapter One. Amino Acid Secondary Transporters

1 Classification of Amino Acid Transporters

2 Human SLCs Involved in Amino Acid and Neurotransmitter Transport

3 The Structural APCS: Mechanistic Concepts

4 Ions and Directionality in Amino Acid Transport

5 Regulation in APCS Fold Transporters

Acknowledgments

References

Chapter Two. SLC5 and SLC2 Transporters in Epithelia—Cellular Role and Molecular Mechanisms

1 Introduction

2 Physiological Significance and Molecular Characteristics of Epithelial Sugar Transport

3 Sodium–Glucose Symport as the Basis for Active Transepithelial Glucose Transport

4 Cloning of Transporter cDNAs, Sequence Homologies and Conserved Amino Acids

5 Transporter Domains, Their Arrangement in the Membrane and Their Function

6 Crystal Structures and Homology Models of Members of SLC5 and SLC2

7 Regulation of Transporter Activity

8 Synopsis

References

Chapter Three. SLC4A Transporters

1 Introduction

2 SLC4A Transporters

3 Ion Transport Properties

4 Structure of SLC4A Transporters

5 Interaction with Other Proteins

6 Conclusion

Acknowledgments

References

Chapter Four. The SLC10 Carrier Family

1 Introduction

2 The SLC10 Family

3 The Liver Bile Salt Transporter SLC10A1 (NTCP)

4 The Ileal Bile Salt Transporter ASBT (SLC10A2)

5 Novel Members of the SLC10 Family

6 Conclusion

Abbreviations

References

Chapter Five. H+-Coupled Divalent Metal-Ion Transporter-1

1 Introduction and History

2 Animal Models

3 Mutations in Human DMT1

4 Functional Properties of DMT1

5 Regulation of the Cellular Expression of