
Co-Transport Systems
Description
Key Features
- Field is cutting-edge and a lot of the information is new to research community
- Wide breadth of topic coverage
- Contributors of high renown and expertise
Readership
Table of Contents
Current Topics In Membranes
Dedication
Contributors
Preface
Previous Volumes In Series
Chapter One. Amino Acid Secondary Transporters
1 Classification of Amino Acid Transporters
2 Human SLCs Involved in Amino Acid and Neurotransmitter Transport
3 The Structural APCS: Mechanistic Concepts
4 Ions and Directionality in Amino Acid Transport
5 Regulation in APCS Fold Transporters
Acknowledgments
References
Chapter Two. SLC5 and SLC2 Transporters in Epithelia—Cellular Role and Molecular Mechanisms
1 Introduction
2 Physiological Significance and Molecular Characteristics of Epithelial Sugar Transport
3 Sodium–Glucose Symport as the Basis for Active Transepithelial Glucose Transport
4 Cloning of Transporter cDNAs, Sequence Homologies and Conserved Amino Acids
5 Transporter Domains, Their Arrangement in the Membrane and Their Function
6 Crystal Structures and Homology Models of Members of SLC5 and SLC2
7 Regulation of Transporter Activity
8 Synopsis
References
Chapter Three. SLC4A Transporters
1 Introduction
2 SLC4A Transporters
3 Ion Transport Properties
4 Structure of SLC4A Transporters
5 Interaction with Other Proteins
6 Conclusion
Acknowledgments
References
Chapter Four. The SLC10 Carrier Family
1 Introduction
2 The SLC10 Family
3 The Liver Bile Salt Transporter SLC10A1 (NTCP)
4 The Ileal Bile Salt Transporter ASBT (SLC10A2)
5 Novel Members of the SLC10 Family
6 Conclusion
Abbreviations
References
Chapter Five. H+-Coupled Divalent Metal-Ion Transporter-1
1 Introduction and History
2 Animal Models
3 Mutations in Human DMT1
4 Functional Properties of DMT1
5 Regulation of the Cellular Expression of DMT1
6 Tissue-Specific Roles of DMT1 in Physiology and Pathophysiology
7 Therapeutics and Nutrition
Acknowledgments
References
Chapter Six. Molecular Operation of the Cation Chloride Cotransporters
1 Overview
2 General Structure
3 Ion Binding and Inhibitor Interaction: Structure–Function Studies
4 Homology to High Resolution Structures of Bacterial Transport Proteins
5 Future Perspectives
Acknowledgments
References
Chapter Seven. Sodium-Sulfate/Carboxylate Cotransporters (SLC13)
1 Introduction
2 SLC13 Gene Family
3 NaS Cotransporters
4 NaC Cotransporters
5 Future Perspectives
Acknowledgments
References
Chapter Eight. Recent Advances in Structural Biology of Peptide Transporters
1 Introduction
2 Functional Characteristics of PEPT1 and PEPT2
3 Structures of PEPT1 and PEPT2
4 Essential Amino Acid Residues
5 Future Perspectives
References
Chapter Nine. The SLC16A Family of Monocarboxylate Transporters (MCTs)—Physiology and Function in Cellular Metabolism, pH Homeostasis, and Fluid Transport
1 Introduction
2 Physiology and Function of MCTs 1–4 in Cellular Metabolism
3 Interactions between MCTs and Bicarbonate Transport Mechanisms
4 Physiology and Function of MCTs 1–4 in Epithelial and Endothelial Cells
5 Future Directions
6 Conclusion
Acknowledgments
References
Chapter Ten. Phosphate Transport Kinetics and Structure-Function Relationships of SLC34 and SLC20 Proteins
1 Introduction
2 Transport Kinetics
3 Structure–Function Relationships
4 Future Perspectives
Abbreviations
Acknowledgments
References
Chapter Eleven. Functional and Physiological Role of Vitamin C Transporters
1 Introduction
2 NAT Family
3 Functional Properties of SVCT1 and SVCT2 (SLC23A1 and SLC23A2)
4 Structure, Phosphorylation and N-Glycosylation of Vitamin C Transporters
5 Physiological Significance
6 Regulation
7 Polymorphisms and Pathological Relevance
8 Outlook
Acknowledgments
References
Index
Product details
- No. of pages: 416
- Language: English
- Copyright: © Academic Press 2012
- Published: December 11, 2012
- Imprint: Academic Press
- Hardcover ISBN: 9780123943163
- eBook ISBN: 9780123946065