CNS Regeneration

CNS Regeneration

Basic Science and Clinical Advances

2nd Edition - December 27, 2007

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  • Editors: Jeffrey Kordower, Mark Tuszynski
  • eBook ISBN: 9780080556987
  • Hardcover ISBN: 9780123739940

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This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury.

Key Features

  • Incorporates information gained from cutting-edge photomicroscopy techniques
  • Includes current information on clinical trials
  • Presents chapters on stem cells and other novel treatments for diseases of the CNS


Neuroscientists and clinical research neurologists

Table of Contents

  • Responses to Injury
    1. Molecular and Genetic Responses to Injury
    Larry Benowitz
    2. Glial Cells, Inflammation and CNS Trauma
    Michael T. Fitch and Jerry Silver

    Stem Cells and Trophic Factors in CNS Repair
    3. Stem Cell Therapy for Brain Tumors
    Rahul Jandial, Allen L. Ho, Michael L Levy and Evan Y. Snyder
    4. Stem Cell Therapy for Parkinson's Disease
    Andreas Androutsellis-Theotokis, Maria A. Rueger and Ron D.G. McKay
    5. Adult Neural Progenitor Cells in CNS Function and Disease
    Sebastian Jessberger, Stefan Aigner, James B. Aimone and Fred H. Gage
    6. Neurotrophic Factors
    Mark Tuszynski

    Novel Therapies for Parkinson’s and Huntington’s Disease
    7. Direct Delivery of GDNF into the Non-human Primate and Human Parkinsonian Brain: Success and Road Blocks
    R. Grodin, Z. Zhang, Y. Ai, J. Slevin, A.B. Young, D.M. Gash and G.A. Gerhardt
    8. Growth Factor Gene Therapy for Parkinon's Disease
    Jeffrey H. Kordower
    9. Stimulating and Ablative Treatment for Parkinson's Disease
    Julie G. Pilitsis and Roy A.E. Bakay
    10. Neurotrophic Factor and Stem Cell Therapy for Huntington's Disease
    Jeffrey H. Kordower

    Novel Therapies for Alzheimer’s Disease
    11. Neurotrophic Factors and Alzheimer's Disease
    Mark Tuszynski
    12. Anti-amyloid-beta Immunotherapy as treatment for Alzheimmer’s Disease
    Joh R. Cirrito and David M. Holtzman

    Novel Therapies for Spinal Cord Injury and White Matter Demyelination
    13. Growth Factors for Spinal Cord Regeneration
    Mark Tuszynski
    14. Modifying the Extracellular Matrix as a Treatment to Impove Functional Recovery After Spinal Cord Injury
    James W. Fawcett
    15. Myelin Neutralization for Spinal Cord Injury and Stroke
    A.R. Walmsley, D. Bourikas and A.K. Mir
    16. Strategies to Inhibit Signaling through Nogo Receptor 1 for Spinal Cord Injury and Stroke
    Jane K. Relton and Paul H. Weinreb
    17. Cyclic AMP Modulation of Axonal Regeneration Following Spinal Cord Injury
    Sari S. Hanilla and marie T. Filbin
    18. Multiple Sclerosis: Remyelination
    Jeffery D. Kocsis, Masanori Sasaki, Karen L Lankford and Christine Radtke

    Design of Clinical Trials
    19. Clinical Trials in Rehabilitation with Neural Repair
    Bruce H. Dobkin

Product details

  • No. of pages: 526
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: December 27, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080556987
  • Hardcover ISBN: 9780123739940

About the Editors

Jeffrey Kordower

Affiliations and Expertise

Rush-Presbyterian Medical Center, Chicago, Illinois, U.S.A.

Mark Tuszynski

Affiliations and Expertise

University of California, San Diego, U.S.A.

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