Clostridium Difficile - 1st Edition - ISBN: 9780125934107, 9781483289052

Clostridium Difficile

1st Edition

Its Role in Intestinal Disease

Editors: Rial D. Rolfe
eBook ISBN: 9781483289052
Imprint: Academic Press
Published Date: 28th March 1988
Page Count: 408
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Description

Despite the tremendous progress made during the last few years in understanding the pathogenesis, epidemiology, diagnosis, and treatment of Clostridium difficile-associated intestinal disease, many extremely important and fundamental questions remain to be answered. The objectives of this book are to summarize the available information regarding Clostridium difficile and its role in intestinal disease and to serve as a basis for future investigations in this challenging area. Clostridium difficile: its role in Intestinal Disease. An excellent volume that should appeal not only to the devotee of C difficile but to all gastroenterologists and microbiologists, this will not languish on my library shelves like so many other books I have reviewed. It will be regularly thumbed. --R.H. George, consultant microbiologist, Children's Hospital, Birmingham Clostridium difficile: Its Role in Intestinal disease. The book is well written and informative; it has a vast amount of information packed in it...this book would be a welcome addition to the researchers and clinicians interested in C difficile-associated intestinal diseases. --Edward Balish, University of Wisconsin Medical School

Readership

Chemical, materials science, mining, and metallurgical engineers.

Table of Contents

Introduction. Historical Aspects. Clinical Aspects of Clostridium difficile-Associated Intestinal Disease. Antimicrobial Agent-Associated Diarrhea in Adult Humans. Clostridium difficile in Infants and Children. Other Clostridial Causes of Diarrhea and Colitis in Man and Animals. Immunological Response to Clostridium difficile Infection. Animal Models of Clostridium difficile-Associated Intestinal Disease. Role of the Hamster Model of Antibiotic-Associated Colitis in Defining the Etiology of the Disease. Other Animal Models of Intestinal Disease Caused by Clostridia. Pathogenic Mechanisms of Clostridium difficile-Associated Intestinal Disease. Purification and Properties of Toxins A and B of Clostridium difficile. Mechanism of Action of Clostridium difficile Toxins. Microbial Ecology of Clostridium difficile. Asymptomatic Intestinal Colonization by Clostridium difficile. Epidemiology of Clostridium difficile-Associated Intestinal Disease. General Epidemiology, Potential Reservoirs, and Typing Procedures. Diagnosis of Clostridium difficile-Associated Intestinal Disease. Pathology and Diagnosis of Clostridium difficile Disease. Isolation and Identification of Clostridium difficile: Tissue Culture Cytotoxicity Assay. Other Potential Diagnostic Techniques. Therapy of Clostridium difficile-Associated Intestinal Disease. Therapy Directed against Clostridium difficile and Its Toxins: Complications of Therapy. Surgical Aspects of Therapy. Prevention of Clostridium difficile-Associated Intestinal Disease. Conclusions. Conclusions and Unanswered Questions. Each chapter includes references. Index.

Details

No. of pages:
408
Language:
English
Copyright:
© Academic Press 1988
Published:
Imprint:
Academic Press
eBook ISBN:
9781483289052

About the Editor

Rial D. Rolfe

Reviews

@qu:An excellent volume that should appeal not only to the devotee of C difficile but to all gastroenterologists and microbiologists, this will not languish on my library shelves like so many other books I have reviewed. It will be regularly thumbed. @source:--R H GEORGE, consultant microbiologist, Children's Hospital, Birmingham (as seen in BMJ)