Clinical Pharmacology - 1st Edition - ISBN: 9780080231969, 9781483188584

Clinical Pharmacology

1st Edition

Proceedings of the 7th International Congress of Pharmacology, Paris 1978

Editors: P. Duchêne-Marullaz J. R. Boissier P. Lechat
eBook ISBN: 9781483188584
Imprint: Pergamon
Published Date: 1st January 1979
Page Count: 290
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Clinical Pharmacology provides a detailed discussion on toxicology. This discussion includes the chemotherapy of parasitic diseases. Some parts of the book focus on topics on immunopharmacology. Such topic as the genetic and environmental factors that contribute to individual’s varying response to drugs is explained. The book covers such topics as the methods and models for the isoniazid acetylation polymorphism. The issues that arise in the administration of drugs in the neonatal period are assessed. Another topic of interest is the effects of diseases on the absorption of drugs. The pharmacokinetic and pharmacodynamic characteristics of a drug are evaluated. The pharmacogenetic investigation amobarbital disposition is presented completely. The book then presents the use and consumption of drugs in different locations and some clinical considerations. The procedures and methods of analysis for such drug are also reviewed . The book can serve as a valuable tool for pharmacists, medical doctors, pediatricians, students, and researchers in the field of medicine.

Table of Contents


The Individual Factor in Drug Response

Genetic and Environmental Factors Responsible for Interindividual Variations in Drug Response

Interindividual Differences in Plasma Concentrations and Effect of the Adrenergic Beta-Receptor Blocking Drug Alprenolol and Its Metabolite 4-Hydroxy-Alprenolol in Man

Interindividual Differences in Drug Response. Studies with Indomethacin and Oral Contraceptive Steroids

Pharmacogenetic Investigation of Amobarbital Disposition

New Methods and Models for the Isoniazid Acetylation Polymorphism

Polymorphic Drug Acetylation and Systemic Lupus Erythematosus

Problems of Drugs Administration in the Neonatal Period

The Effect of Disease on the Response to Drugs

Drug Utilization: Geographical Differences and Clinical Implications

Introductory Remarks

Methodologies and Approaches in Drug Utilization Studies

Drug Prescribing in Hospitals: an International Comparison

Drug Utilization Strategies within Regional Programs on Drug Control and Evaluation

Drug Utilization - Geographical Differences and Clinical Implications - Psychotropic Drugs

Drug Utilization - Geographical Differences and Clinical Implications - Antidiabetic Drugs

Antihypertensive Drugs

Digoxin - Compliance as a Factor in Drug Utilization

Drug Utilization, the Role and Effect of Clinical Pharmacology

Controls of Drug Utilization: National and International Implications

Drug Utilization - Geographical Differences and Clinical Implications Concluding Remarks

Surveillance of Drugs in Therapeutic Use

Surveillance of Drugs in Therapeutic Use

Registered Release: a Method for Detecting Adverse Drug Reactions

Surveillance of Drugs in Therapeutic Use in Developing Countries

Methods of "Audit" in Drug Use

The Value and Limitations of Patient Registers in Drug Surveillance

Experiences of the Boston Collaborative Drug Surveillance Program

New Development in Antiarrhythmic Drugs

Relevance of "In Vitro" Electrophysiologic Effects of Antiarrhythmic Drugs to Their Efficacy under "In Vivo" Conditions

Arrhythmias Caused by Cardiac Glycosides

Experimentation in the Unanaesthetized Dog in the Study of Antiarrhythmics

From Experiment to Therapeutic Application in the Field of Antiarrhythmics

Clinical Use of Antiarrhythmic Drugs. The Relevance of Experimental Data

New Antiarrhythmics. The Need for Bridging the Gap between the Pharmacologist and the Clinician

Theoretical Considerations concerning Drug Treatment of Dysrhythmias Due to Coronary Insufficiency



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About the Editor

P. Duchêne-Marullaz

J. R. Boissier

P. Lechat

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