Clinical Neurophysiology: Basis and Technical Aspects

Clinical Neurophysiology: Basis and Technical Aspects

Handbook of Clinical Neurology Series

1st Edition - July 3, 2019

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  • Editors: Kerry Levin, Patrick Chauvel
  • eBook ISBN: 9780444640338
  • Hardcover ISBN: 9780444640321

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Clinical Neurophysiology: Basis and Technical Aspects, the latest release in the Handbook of Clinical Neurology series, is organized into sections on basic physiological concepts, on the function and limitations of modern instrumentation, and on other fundamental or methodologic aspects related to the recording of various bioelectric signals from the nervous system for clinical or investigative purposes. There is discussion of the EEG, nerve conduction studies, needle electromyography, intra-operative clinical neurophysiology, sleep physiology and studies, the autonomic nervous system, various sensory evoked potentials, and cognitive neurophysiology.

Key Features

  • Provides an up-to-date review on the practice of neurophysiological techniques in the assessment of neurological disease
  • Explores the electrophysiological techniques used to better understand neurological function and dysfunction, first in the area of consciousness and epilepsy, then in the areas of the peripheral nervous system and sleep
  • Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, magnetoencephalography, laser evoked potentials, and transcranial magnetic stimulation


Basic and clinical researchers in neuroscience and neurophysiology; fellows, residents, and practicing clinicians in neurology, clinical neurophysiology, sleep medicine, subspecialists in epilepsy, neuromuscular diseases

Table of Contents

  • Section 1. Basic Physiological and Recording Concepts
    1. Generation and propagation of the action potential
    2. Volume conduction, waveform analysis, and near and far field potentials
    3. Instrumentation for electrodiagnostic studies
    4. Filtering of neurophysiological signals
    5. Electrical safety

    Section 2. EEG: Technologic Aspects and Basic Rhythms
    6. EEG source localization
    7. Adult EEG
    8. Child EEG (and maturation)
    9. Normal EEG variants
    10. Ambulatory EEG
    11. Video-EEG
    12. High-resolution EEG
    13. Magnetoencephalography for localizing and characterizing the epileptic focus

    Section 3. Nerve Conduction Studies, Methods and Techniques
    14. Nerve conduction studies: Basic concepts
    15. F wave, A wave, H reflex, and blink reflex

    Section 4. Needle Electromyography, Methods and Techniques
    16. Needle electromyography: basic concepts
    17. Normal and abnormal spontaneous activity
    18. Normal and abnormal voluntary activity
    19. Single fiber EMG

    Section 5. Intra-operative Clinical Neurophysiology, MEP, SSEP
    20. Electrocorticography and functional mapping
    21. Spinal cord monitoring
    22. Electrophysiological mapping for deep brain stimulation for movement disorders

    Section 6. Sleep Physiology and Studies
    23. Sleep-wake physiology
    24. Practical aspects of actigraphy and approaches in clinical and research domains
    25. Polysomnography
    26. The Multiple sleep latency test

    Section 7. Autonomic Nervous System: Basic and Technical Aspects
    27. Basics of autonomic nervous system function
    28. Autonomic testing, methods and techniques

    Section 8. Auditory, Visual and Somatosensory Evoked Potentials
    29. Cochlea and auditory nerve
    30. Auditory brainstem response
    31. The auditory and association cortex and language evaluation methods
    32. Electroretinograms
    33. The Electrooculogram
    34. Visually evoked potentials
    35. Somatosensory evoked potentials

    Section 9. Cognitive Neurophysiology
    36. Cognitive neurophysiology: event-related potentials
    37. Transcranial magnetic stimulation

Product details

  • No. of pages: 622
  • Language: English
  • Copyright: © Elsevier 2019
  • Published: July 3, 2019
  • Imprint: Elsevier
  • eBook ISBN: 9780444640338
  • Hardcover ISBN: 9780444640321

About the Series Volume Editors

Kerry Levin

Dr. Levin began his position at Cleveland Clinic in 1984 as a neurologist and currently serves in multiple capacities, including Chair of the Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Program Director for neurophysiology and neuromuscular fellowships and Professor at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. Twice awarded Teacher of the Year by the Neurology Department, Dr. Levin's specialties are electromyography and clinical neuromuscular diseases. Dr. Levin is a fellow of the American Academy of Neurology and of the American Association of Electrodiagnostic Medicine, and his been elected to membership in the American Neurological Association. He has held leadership positions in these and other professional associations and sits on the editorial board of Muscle and Nerve. The author of several books and many articles, Dr. Levin is also engaged in clinical research with interests ranging from the electrodiagnosis of radiculopathy and defects of neuromuscular junction transmission, to the treatment of polyneuropathy.

Affiliations and Expertise

Chair, Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Cleveland Clinic, Cleveland, OH, USA

Patrick Chauvel

After becoming an INSERM (Paris) researcher, Pr. Chauvel began his work in experimental and later clinical research into the mechanisms of the epilepsies. Under the mentorship of Talairach and Bancaud at Hopital Sainte-Anne, Paris, he developed SEEG (StereoElectroEncephalography) as a presurgical method in epilepsy surgery. His research work has been devoted to the neurophysiology of the epileptogenic zone, emergence of seizure clinical semiology in relation to intracerebral recording, and cerebral cortex physiology. He has promoted the concept of epileptogenic network over the classical epileptic focus idea, and opened new vistas in markers of the epileptogenic zone and pathophysiology of frontal epilepsies. Pr. Chauvel served as the Director of the SEEG Unit in Hôpital Sainte-Anne in Paris (1986-1990), then Professor and Chairman of Neurology in Rennes (1990-1997) where he configured a new type of Epilepsy Unit including research, then Professor and Chairman of Clinical Neurophysiology and Director of the INSERM Institute of Systems Neuroscience in Marseille (1997-2014). In 2014, he relocated to the Epilepsy Center of the Cleveland Clinic, in order to promote the development of presurgical investigation using SEEG in North America. He is the author of 250 original articles in international journals and is a member of several Scientific and Medical Societies, both French and International. He has been elected as a Member of the Belgian Royal Academy of Medicine.

Affiliations and Expertise

Professor of Neurology, University of Pittsburgh Medical Center, Department of Neurology, Pittsburgh, Pennsylvania

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