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Clinical Neurophysiology: Diseases and Disorders - 1st Edition - ISBN: 9780444641427, 9780444641434

Clinical Neurophysiology: Diseases and Disorders, Volume 161

1st Edition

Handbook of Clinical Neurology Series

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Series Volume Editors: Kerry Levin Patrick Chauvel
Hardcover ISBN: 9780444641427
eBook ISBN: 9780444641434
Imprint: Elsevier
Published Date: 9th August 2019
Page Count: 486
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Table of Contents

Section 10. Clinical Neurophysiology of Central Nervous System Disease States
38. Generalized epilepsies
39. Focal epilepsies and focal disorders
40. Presurgical intracranial investigations in epilepsy surgery
41. Clinical neurophysiology of altered states of consciousness: encephalopathy and coma
42. Brain death
43. Monitoring for seizures in the intensive care unit
44. Clinical neurophysiology of stroke
45. Clinical neurophysiology of pain
46. Tremor and myoclonus
47. Motor cortical circuits in Parkinson disease and dystonia
48. Clinical Neurophysiology of Neurological Rehabilitation

Section 11. Clinical Neurophysiology of Peripheral Nervous System Disease States
49. Upper extremity neuropathies
50. Clinical neurophysiology of lower extremity focal neuropathies
51. Clinical electrophysiology of axonal polyneuropathies
52. Clinical neurophysiology of demyelinating polyneuropathy
53. Clinical electrophysiology of muscle diseases and episodic muscle disorders
54. Peripheral nerve hyperexcitability 
55. Clinical neurophysiology of neuromuscular junction disease
56. Electrodiagnosis of radiculopathy
57. Clinical neurophysiology of anterior horn cell disorders
58. Clinical neurophysiology of cranial nerve disorders

Section 12. Clinical Neurophysiology of Sleep Disorders
59. Clinical neurophysiology of apnea
60. Clinical neurophysiology of CNS hypersomnias
61. Clinical neurophysiology of circadian rhythm sleep-wake disorders
62. Clinical neurophysiology of REM parasomnias
63. Clinical neurophysiology of NREM parasomnias

Section 13. Clinical Neurophysiology of Autonomic Disorders
64. Pure autonomic failure
65. Clinical neurophysiology of multisystem atrophy
66. Clinical neurophysiology of postural tachycardia syndrome



Clinical Neurophysiology: Diseases and Disorders, the latest release in the Handbook of Clinical Neurology series, reviews the current practice of clinical neurophysiology in the laboratory, by the bedside, and in the operating room or intensive care unit. The volume is organized into sections focused on diseases of the central and peripheral nervous systems, sleep disorders, and autonomic disorders. Among the CNS topics covered are epilepsy, altered states of consciousness, disorders of cognition, brain death, demyelinating diseases, stroke, pain, movement disorders, vestibular disease, and auditory disorders. Peripheral nervous system topics include focal mononeuropathies, generalized polyneuropathies, muscle diseases, hyperexcitability states, neuromuscular junction disorders, anterior horn cells diseases, and cranial neuropathies.
There are also chapters on sleep apneas, hypersomnias, parasomnias, and circadian rhythm disorders. Autonomic topics include primary autonomic failure, multisystem atrophy, and postural orthostatic tachycardia syndrome.


Key Features

  • Provides an up-to-date review on the practice of the neurophysiological techniques used in the assessment of neurological diseases
  • Explores the electrophysiological techniques used to better understand neurological function and dysfunction of the central and peripheral nervous systems
  • Discusses monitoring neurologic function in the intensive care unit and the assessment of suspected brain death
  • Includes discussions of various newer techniques, including functional brain mapping, stereo EEG, motor evoked potentials, magnetoencephalography, laser evoked potentials, and transcranial magnetic stimulation


Basic and clinical researchers in neuroscience and neurophysiology; fellows, residents, and practicing clinicians in neurology, clinical neurophysiology, sleep medicine, subspecialists in epilepsy, neuromuscular diseases


No. of pages:
© Elsevier 2019
9th August 2019
Hardcover ISBN:
eBook ISBN:


"For individuals who are looking for a concise, but in depth, review of a specific neurophysiological technique, this is the text for you. Editors Levin and Chauvel provide a thoughtful examination of the technical characteristics of a variety of neurophysiological techniques. There do not appear to have been any corners cut in describing the technical aspects of each measurement procedure. As a whole, the volume represents a significant advancement to the rapidly evolving field of clinical neurophysiology." -- Applied Neuropsychology-Adult, April 2020

Ratings and Reviews

About the Series Volume Editors

Kerry Levin

Dr. Levin began his position at Cleveland Clinic in 1984 as a neurologist and currently serves in multiple capacities, including Chair of the Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Program Director for neurophysiology and neuromuscular fellowships and Professor at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. Twice awarded Teacher of the Year by the Neurology Department, Dr. Levin's specialties are electromyography and clinical neuromuscular diseases. Dr. Levin is a fellow of the American Academy of Neurology and of the American Association of Electrodiagnostic Medicine, and his been elected to membership in the American Neurological Association. He has held leadership positions in these and other professional associations and sits on the editorial board of Muscle and Nerve. The author of several books and many articles, Dr. Levin is also engaged in clinical research with interests ranging from the electrodiagnosis of radiculopathy and defects of neuromuscular junction transmission, to the treatment of polyneuropathy.

Affiliations and Expertise

Chair, Department of Neurology, Director of the Neuromuscular Center at the Neurological Institute, Cleveland Clinic, Cleveland, OH, USA

Patrick Chauvel

After becoming an INSERM (Paris) researcher, Pr. Chauvel began his work in experimental and later clinical research into the mechanisms of the epilepsies. Under the mentorship of Talairach and Bancaud at Hopital Sainte-Anne, Paris, he developed SEEG (StereoElectroEncephalography) as a presurgical method in epilepsy surgery. His research work has been devoted to the neurophysiology of the epileptogenic zone, emergence of seizure clinical semiology in relation to intracerebral recording, and cerebral cortex physiology. He has promoted the concept of epileptogenic network over the classical epileptic focus idea, and opened new vistas in markers of the epileptogenic zone and pathophysiology of frontal epilepsies. Pr. Chauvel served as the Director of the SEEG Unit in Hôpital Sainte-Anne in Paris (1986-1990), then Professor and Chairman of Neurology in Rennes (1990-1997) where he configured a new type of Epilepsy Unit including research, then Professor and Chairman of Clinical Neurophysiology and Director of the INSERM Institute of Systems Neuroscience in Marseille (1997-2014). In 2014, he relocated to the Epilepsy Center of the Cleveland Clinic, in order to promote the development of presurgical investigation using SEEG in North America. He is the author of 250 original articles in international journals and is a member of several Scientific and Medical Societies, both French and International. He has been elected as a Member of the Belgian Royal Academy of Medicine.

Affiliations and Expertise

Staff Neurologist in the Epilepsy Center at the Neurological Institute, Cleveland, OH, USA