Chromatographic Systems

Chromatographic Systems

Maintenance And Troubleshooting

2nd Edition - August 28, 1977

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  • Author: John Q. Walker
  • eBook ISBN: 9780323161848

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Chromatographic Systems: Maintenance and Troubleshooting, Second Edition provides a clear and concise guide for chromatographic maintenance. This book covers troubleshooting and repair procedures that can be utilized by both experienced and inexperienced chemists and technicians to reduce instrument down-time. This edition is divided into two parts. Part I focuses on liquid chromatography, which consists of an introductory chapter on principles, techniques, and utility, followed by specific chapters devoted to the individual systems comprising the total liquid chromatographic makeup. Gas chromatography is emphasized in Part II, introducing the basic theory and analyzing the systematic progression through possible malfunctions in various parts of the gas chromatograph. This publication is a good source for chromatographers, scientists, chemists, and technicians interested in the maintenance and troubleshooting of chromatographic systems.

Table of Contents

  • Preface to Second Edition

    Preface to First Edition


    Part I — Liquid Chromatography

    Chapter 1 Chromatographic Systems: Maintenance and Troubleshooting

    Chapter 2 Solvent Delivery Systems


    General Design—Pulsed vs. Pulseless

    Ideal Design

    Routine Maintenance and Cleaning-Solvents, Changing Solvents,

    Seals, Gaskets

    Problems and Solutions

    Chapter 3 LC Sample Introduction Systems


    General Design—Loop Injectors, Septa, Syringes, Dead-Volume

    Ideal Design—Loop Injector, Dead-Volume

    Routine Maintenance and Cleaning-Solvents

    Problems and Solutions

    Chapter 4 LC Columns (Selection & Preparation), Column Ovens and Column Heaters

    Selecting the Type of Separation—Liquid-Liquid, Liquid-Solid, Gel Permeation, Ion Exchange

    Choice of Materials—Stainless Steel, Glass Fittings, Couplings

    Methods Associated with Packing Columns

    Column Assembly—Pre-Columns, Purge, Dead-Volume

    Problems and Solutions

    Chapter 5 LC Detection Systems


    General Designs—Refractive Index, Ultraviolet, Flame, Wire-Filament, Fluorimeter

    Ideal Design

    Routine Maintenance and Cleaning-Solvents

    Problems and Solutions

    Chapter 6 Comprehensive Troubleshooting of LC Systems

    Baseline Problems—Noise, Drift, Spikes, Stair-Stepping

    Poor Peak Shapes

    Loss of Resolution

    Pump and Flow Problems

    Other Problems

    Part II — Gas Chromatography

    Chapter 7 Introduction to Gas Chromatography

    Chapter 8 Pneumatic and Sample Introduction Systems

    Carrier Gas Filters

    Pressure Regulators


    Flow Controllers

    Sample Inlet Systems

    Gas Valves and Splitters

    Flow Programmers

    Routine Maintenance and Troubleshooting

    Problems and Solutions

    Chapter 9 Pyrolytic Inlet Systems



    Comparison of Performance of Various Pyrolyzers


    Problems and Solutions

    Chapter 10 Gas Chromatographic Column Ovens and Temperature Controllers

    Column Arrangements

    Oven designs

    Temperature Controllers and Programmers

    Routine Maintenance

    Problems and Solutions

    Chapter 11 Gas Chromatography Detectors


    Terms and Formulas

    Types of Detectors: Thermal Conductivity, Flame Ionization, Electron Capture, and Other Types of Detectors


    Troubleshooting TCD, FID, ECD

    Problems and Solutions

    Chapter 12 Integral Electronics


    TCD Electrical Circuits



    Computer Linkups

    Problems and Solutions

    Chapter 13 Auxiliary Systems

    GC Interfaces: I.R., U.V., M.S. Problems and Solutions

    Chapter 14 Gas Chromatographic Comprehensive Troubleshooting

    Baseline Problems: Drift,Noise, Zeroing, Cycling, Spikes

    Distorted Peaks, Ghost Peaks, Others

    Reproducibility Problems: Retention Time, Sensitivity Changes. Other Problems

    Appendix A Cleaning of GC Detectors

    Appendix B Care and Handling of Microsyringes

    Appendix C Troubleshooting Clues from the Rotameter

    Appendix D Troubleshooting of Silicon Controlled Rectifier (SCR) Heating Systems

    Appendix E A Rapid Fault Isolation Method

    Appendix F Gas Chromatographie Column Preparation

    Appendix G Glossary of Terms and Formulas

    Appendix H Packing and Installation Technique for G.C. Columns

    Appendix I Conditioning of G.C. Columns

    Appendix J Routine Maintenance of Your G.C.

    Appendix K Gas Chromatography Operating Hints


Product details

  • No. of pages: 376
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: August 28, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323161848

About the Author

John Q. Walker

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