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Chromatin: Structure, Function and History brings the reader up-to-date on the remarkable progress made in chromatin research. Coverage includes the basics of chromatin biology, particularly early work on chromatin structure and function, followed by review of research done since the early nineties, particularly on chromatin modifications and chromatin remodeling, which has led to the explosion of interest in epigenetics. The fundamentals of chromatin structure and biochemistry and the enzyme complexes that manage it are thoroughly addressed, and considerable attention is given to genome-wide approaches to its study. The book provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. By consistently interrelating the structure of eukaryotic DNA with the nuclear processes it undergoes, this volume becomes essential reading for researchers and students who want to really understand how DNA works.
- Provide a current and easily digestible resource on chromatin and epigenetics
- Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease
- Valuably covers the background of the field – the history of the nucleosome and the early days of chromatin research – enabling readers to understand how the field was born and what discoveries and technical advances have propelled it forward
Researchers and advanced students in the fields of biochemistry, molecular biology, cell biology and genetics
Part I. Chromatin structure
1. Early history
2. Figuring out the nucleosome
3. Nucleosome positioning
Part 2. Chromatin function
4. Early studies
5. Chromatin remodeling
6. Chromatin modifications
- No. of pages:
- © Academic Press 2021
- 1st December 2021
- Academic Press
- Paperback ISBN:
The author has more than 30 years’ experience in the fields of biochemistry, molecular biology and genetics, much of which has involved research involving Chromatin structure, function and genetics. He has been teaching this topic in intro graduate level courses since 1994, has participated in numerous conferences devoted to chromatin research, and has obtained grants and published articles involving research on chromatin structure and function.
Research Scientist, Division of Genetic Disorders, Wadsworth Center, NY State Department of Health and SUNY School of Public Health
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