Cholesterol Metabolism, LDL, and the LDL Receptor

Cholesterol Metabolism, LDL, and the LDL Receptor

1st Edition - June 28, 1990

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  • Author: N Myant
  • eBook ISBN: 9780323148870

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Description

Cholesterol Metabolism, LDL, and the LDL Receptor focuses on the cholesterol biochemistry and lipoprotein metabolism. This book is organized into 10 chapters that describe the coordinated actions of three regulated processes, namely, the intracellular synthesis of cholesterol, its esterification by ACAT, and the receptor-mediated uptake of low-density lipoprotein (LDL), for optimal level of free cholesterol. The first five chapters explore the various aspects of cholesterol biology, including discussions on the interaction of ligands with their cell-surface receptors; the role of coated pits in the endocytosis of receptor-bound ligands; and the recycling of receptors through the interior of the cell. These chapters also examine the regulation of gene expression encoding inducible proteins and the use of natural and synthetic mutations in studies of the functions of the separate domains of a multifunctional protein. A chapter describes the cloning of the apoB gene, the receptor-binding domain of apoB-100, and the unusual mode of derivation of apoB-48. Considerable chapters are devoted to LDL receptor and its pathway. The concluding chapter deals with the clinical consequences of genetic dysfunction of the LDL receptor, with particular emphasis on the diagnostic and treatment approaches of familial hypercholesterolemia that are based wholly or in part on knowledge of the LDL receptor or its gene. This book is an indispensable guide for biologists, physiologists, and clinicians who are interested in the epidemiological field of cholesterol and heart attacks.

Table of Contents


  • Foreword: Simplifying Cholesterol Metabolism

    Preface

    Acknowledgments

    1. The LDL Receptor in Perspective

    2. Cholesterol in Animal Tissues

    I. Functions and Distribution

    II. Sources of Cholesterol in Different Tissues

    III. Measurement of Whole-Body Synthesis of Cholesterol

    References

    3. HMG-CoA Reductase

    I. The Rate-Limiting Step in Cholesterol Biosynthesis

    II. Composition, Structure, and Orientation

    III. The HMG-CoA Reductase Gene and Its mRNA

    IV. Somatic-Cell Mutants in the Study of Cholesterol Metabolism

    V. The Regulation of HMG-CoA Reductase

    References

    4. Acyl-CoA: Cholesterol Acyltransferase

    I. Biological Functions

    II. Properties and Methods of Assay

    III. ACAT and the Metabolism of Intracellular Cholesteryl Esters

    IV. Regulation of ACAT

    References

    5. LDL: Physical and Chemical Characteristics

    I. Composition and Physical Characteristics

    II. Structure

    III. Heterogeneity and Genetic Polymorphism

    References

    6. Apolipoprotein Β (apoB)

    I. LDL ApoB: Definition and Some Properties

    II. ApoB Species in Human Plasma

    III. Composition and Structure of ApoB-100

    IV. Lp(a): A Lipoprotein Containing ApoB-100

    V. The LDL-Receptor-Binding Site on ApoB

    VI. The ApoB Gene and Its mRNA

    VII. Polymorphism in the Human ApoB Gene

    VIII. Polymorphism in the ApoB Gene in Animals

    IX. ApoB (Arg3500→Gln): A Rare Variant

    X. Mutations Causing Absence or Deficiency of Plasma ApoB

    References

    7. LDL: Origin and Metabolism

    I. The Production of LDL

    II. LDL Catabolism In Vivo

    References

    8. The LDL Receptor: Biochemistry and Cell Biology

    I. Historical Background

    II. Surface Binding and Intracellular Degradation of LDL

    III. LDL Receptors in Nonfibroblast Cells

    IV. Effects of Growth Factors and Hormones In Vitro

    References

    9. The LDL Receptor: Structure, Biosynthesis, and Molecular Genetics

    I. The Route to Isolation of the Human Receptor and Its Gene

    II. The Normal LDL Receptor

    III. The LDL-Receptor Gene and Its Message

    IV. Regulation of Expression of the Receptor Gene

    V. Natural Mutations at the Receptor Locus

    VI. Somatic-Cell Mutations

    VII. Polymorphism in the LDL-Receptor Gene

    VIII. Evolutionary Aspects of the Receptor Gene

    References

    10. Normal and Defective LDL-Receptor Function In Vivo

    I. Introduction

    II. Comparison between LDL-Receptor Function In Vitro and In Vivo

    III. Familial Hypercholesterolemia: A Consequence of LDL-Receptor Deficiency

    IV. The WHHL Rabbit

    References

    Glossary

    Appendix A: Abbreviations for Amino Acids

    Appendix B: Abbreviations for Nucleotide Bases

    Index


Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: June 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323148870

About the Author

N Myant

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