Chiral Analysis - 2nd Edition - ISBN: 9780444640277, 9780444640284

Chiral Analysis

2nd Edition

Advances in Spectroscopy, Chromatography and Emerging Methods

Editors: P.L. Polavarapu
eBook ISBN: 9780444640284
Paperback ISBN: 9780444640277
Imprint: Elsevier Science
Published Date: 1st June 2018
Page Count: 700
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Chiral Analysis: Advances in Spectroscopy, Chromatography and Emerging Methods, Second Edition covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals, including chemistry graduate students, analytical chemists, organic chemists, professionals in the pharmaceutical industry, and others with an interest in chirality and chiral analysis. This thoroughly revised second edition covers several new, important areas of chiral analysis that have emerged since the first edition.

Three of the new methods provide higher sensitivity than can be realized with the current methods and are expected to become mainstream applications: cavity based methods offer vastly higher sensitivity than conventional polarimetric methods, microwave chiral detection provides unsurpassed sensitivity for identifying diastereomers, and the rotating electric field method offers a competing new approach for the separation of enantiomers. Another topic, chirality in extraterrestrial life, has not been discussed in any other book and is important for understanding the origin of life.

Key Features

  • Offers the only book to cover both spectroscopic and separation methods in a single volume
  • Provides an up-to-date and detailed review of the various techniques available, including new techniques that have emerged since the first edition
  • Includes contributions from a range of leading experts in the field, now edited by award-winning chirality researcher Prasad Polavarapu


Scientific professionals with an undergraduate background in chemistry or a related discipline, specifically analytical chemists, medicinal and organic chemists; researchers in drug discovery, pharmaceutical researchers involved with process analysis or combinatorial libraries; graduate students in chemistry; regulatory food and drugs agencies, environmental agencies

Table of Contents

1. Historical Introduction to Chirality

Chirality in Nature
2. Chiral Asymmetry in Nature
3. Chirality in Extraterrestrial Life

Established Spectroscopic Methods, Advances and Analyses
4. Light Polarization Techniques and Phase-Sensitive Detection
5. Chiral Molecular Tools Powerful for the Preparation of Enantiopure Compounds and Unambiguous Determination of their Absolute Configurations
6. A Chiroptical Probe for Determination of Absolute Stereochemistry by CD Excitron Chirality Method
7. Vibrational Optical Activity in Chiral Analysis
8. Vibrational Raman Optical Activity
9. Complete Analysis of Chiroptical Spectra
10. Advances in Chiral Analysis by NMR Spectroscopy
11. Chiral Analysis in Mass Spectrometry: Applications of Chromatography and Ion Mobility
12. Chiral Analysis in Pharmaceutical Industry
13. Chiroptical Spectroscopy of Biofluids
14. Chiral Analysis of Nanoscale Objects
15. Regression Modeling of Chiroptical Spectra

Chromatographic Methods
16. Chiral Analysis Using Gas Chromatography
17. Chiral Analysis Using HPLC
18. Chiral Analysis by Capillary Electromigration Techniques

Novel Emerging Methods
19. Cavity-based Chiral Polarimetry
20. Chiral Analysis by High-Resolution Molecular Rotational Spectroscopy
21. Chiral Rotational Spectroscopy
22. Chiral Analysis Using Rotating Electric Fields
23. Coulomb Explosion Imaging of Chiral Molecules


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© Elsevier Science 2018
Elsevier Science
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About the Editor

P.L. Polavarapu

Professor Polavarapu obtained his Master of Science degree in 1972 from Birla Institute of Technology, Pilani, and earned his Ph. D at the Indian Institute of Technology, Madras (now renamed as Chennai). He conducted research at the University of Toledo, Toledo, OH, and Syracuse University, Syracuse, NY before joining Vanderbilt University, Nashville, TN, as an Assistant Professor of Chemistry, where he later became a Professor. Professor Polavarapu has made pioneering contributions in the research areas of specific optical rotation, vibrational Raman optical activity, vibrational circular dichroism, and electronic circular dichroism (collectively referred to as Chiroptical Spectroscopy). His research work led to determination of the absolute configurations of bromochlorofluoromethane and isoflurane (a fluorinated ether used as an anesthetic) for the first time. He has published approximately 260 peer reviewed research papers in leading scientific journals. Professor Polavarapu edited a book entitled “Polarization Division Interferometry” (John Wiley & Sons, 1997) with a contribution from Dr. John Mather, who won the 2006 Nobel Prize in Physics; published a solo book “Vibrational Spectroscopy: Principles and Applications with Emphasis on Optical Activity” (Elsevier, 1998); co-edited two volumes on “Comprehensive Chiroptical Spectroscopy” (John Wiley & Sons, 2012), with a contribution from Professor Ben Ferringa, who won the 2016 Nobel Prize in Chemistry. His latest book “Chiroptical Spectroscopy: Fundamentals and Applications” (CRC Press, 2016) was written to serve as a text book for graduate level course. Professor Polavarapu was awarded the Jeffrey Nordhaus Award (in 2010) for excellence in undergraduate teaching at Vanderbilt University. He was elected (in 2012) as a Fellow of the American Association for Advancement of Science (AAAS) for distinguished contributions to the field of chiral molecular structure determination. He was an Erudite Scholar (in November 2010) and Distinguished Consulting Research Professor (in 2012) at Mahatma Gandhi University, Kottayam. He currently serves on the editorial board of Chirality journal.

Affiliations and Expertise

Vanderbilt University, Nashville, TN, USA

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