Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids - 1st Edition - ISBN: 9780080237992, 9781483146034

Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids

1st Edition

Including the Proceedings of a Symposium on the Chemistry and Biochemistry of Prostanoids Held at The University of Salford, England, 10-14 July 1978

Editors: Stanley M. Roberts Feodor Scheinmann
eBook ISBN: 9781483146034
Imprint: Pergamon
Published Date: 1st January 1979
Page Count: 420
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Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids contains the proceedings of a symposium on the Chemistry and Biochemistry of Prostanoids held at the University of Salford, England on July 10-14, 1978. Separating 29 papers of the symposium as chapters, this book begins with a description of prostanoids in health and disease and recent developments in the synthesis of antisecretory prostaglandins. Other topics discuss synthesis of some novel 11-deoxyprostaglandins; bicycles, tricycles and prostaglandin synthesis; chemical and biological studies on new prostanoids; and isolation and characterization of enzymes involved in prostaglandin biosynthesis. Structure activity relationships of prostaglandins and a biochemical background of caloric restriction therapy of obesity are also explained.

Table of Contents


Preface,Introduction to Nomenclature,and Acknowledgments

Prostanoids in Health and Disease

Recent Developments in the Synthesis of Antisecretary Prostaglandins

Synthesis of Some Novel 11-Deoxyprostaglandins

Synthesis and Bronchial Dilator Activity of Some Novel Prostaglandin Analogues

Bicycles, Tricycles and Prostaglandin Synthesis

The Total Synthesis of(±)Prostaglandin

Chemical and Biological Studies on New Prostanoids

A Method for the Inversion of Configuration of Alcohols

The Synthesis of Compounds Formed in the Arachidonic Acid

Cascade and Agents Which Modulate their Production

On the Existence of the Existence of 6(9α)-Oxido-11α,15(S)-dihydroxyprosta-7(8),(E)13-dienoic Acid

Novel Metabolite of Arachidonic Acid

Bicyclo[3,2,0] heptan-2-ones; a Photochemical Route to Prostanoid Synthons

The Synthesis of Cyclopentenolone Precursors to Prostaglandins from Furan Derivatives

A General Synthesis of the Prostaglandins from Butadiene and Levulinic Acid

A New Stereoselective Synthesis of Prostaglandins

Biologically Active 11-Deoxyprostaglandins

Thromboxane-like Activity of Prostanoids with Aromatic Substituents at C-16 and C-17

Biosynthesis of Prostaglandins and Thromboxanes

Isolation and Chracterization of Enzymes involved in Prostaglandin Biosynthesis

15-Deoxy-16-hydroxyprostaglandins.Synthesis and Bronchodilator Activity

Prostacyclin Formation and Effects

Synthesis and Stereochemistry of Stable Prostacyclin Analogues

Synthesis and Biological Properties of Prostacyclins and Prostaglandin Endoperoxide Analogs

The 6(9)Oxy Cyclase Pathway of Prostaglandin Endoperoxide Metabolism

The Gastric Antisecretory Properties of Some Prostaglandin Analogues

Structure Activity Relationships of Prostaglandins

The Cleavage of Silyloxy-groups by Boron Trifluoride Etherate

15-Deoxy-16-hydroxy-PGE1 Carbinols. Synthesis and Biological Activity

A Biochemical Background of Calory Restriction Therapy of Obesity: Lipid Peroxide Mobilization

The Synthesis and Biological Properties of 9α,11α-Trithiocarbonate of 9α,llα-Bisdeoxy-PGF2. A Mimic of Prostaglandin Endoperoxide

Author Index

Subject Index


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© Pergamon 1979
eBook ISBN:

About the Editor

Stanley M. Roberts

Feodor Scheinmann

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