Chemistry and Biology of Nucleosides and Nucleotides

1st Edition - January 1, 1978
Editor: Robert Harmon
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 8 2 7 - 6

Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on… Read more

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Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

List of Contributors

Preface

Total Synthesis of a Bacterial Gene II: The Total DNA Including the Promotor and Its Transcription

Total Synthesis of Bacterial Gene I: Chemical Synthesis of Oligonucleotides and Use of High-Pressure Liquid Chromatography

The Use of Microparticulate Reversed-Phase Packing in High-Pressure Liquid Chromatography of Nucleosides

Chemical and Enzymatic Methods in the Synthesis of Modified Polynucleotides

Simple Models of Nucleic Acid Interactions

Synthesis of Nucleotides which Inactivate Enzymes Utilizing Adenine Nucleotides

Synthesis, Antiviral Activity, and Mechanism of Action of a Novel Series of Pyrimidine Nucleoside Analogs

The Chemistry and Biological Activity of C-Nucleosides Related to Pseudouridine

The Chemistry and Biological Activity of Certain 4-Substituted and 3,4-Disubstituted Pyrazolo (3,4-d) Pyrimidine Nucleosides

The Chemistry and Biology of Some New Nucleoside Analogs Active against Tumor Cells

Potentiation of the Chemotherapeutic Action of Antineoplastic Agents

Coformycin and Deoxycoformycin: Tight-Binding Inhibitors of Adenoxine Deaminase

Synthesis and Chemistry of a New Antiviral-Antibiotic Nucleoside in Anhydro Form: Application of a Novel 1,3-Electrophilic (C-N-C) Annulation Reagent

Synthesis of 1-(2-Deoxy-ß-D-Ribofuranosyl)-5,6-Dihydro-5-Methyl-s-Triazin-2,4(1H,3H)Dione

An Approach to the Synthesis of 1,9-Diribosyl Purine

An Initial Study on the Selectivity and Stereospecificity of the Ribosylation Reaction

On the Mechanism of Nucleoside Synthesis

Synthesis and Chemistry of Certain Azole Nucleosides

The Synthesis of Heterocyclic Analogs of Purine Nucleosides and Nucleotides Containing a Bridgehead Nitrogen Atom

Determination of the Site of Glycosylation in Various Nucleosides by Carbon-13 NMR Spectroscopy

A "Geometry-Only" 1Ή NMR Method for Determination of the Anomeric Configuration of Ribofuranosyl Compounds

Investigation of Nucleoside Alkylphosphonates

The Tert-Butyldimethylsilyl Group as a Protecting Group in Oligonucleotide Synthesis

Advances in the Synthesis of C-Glycosyl Nucleosides

Synthesis of C-Glycosyl Thiazoles

A New Method for the Synthesis of 2'-Deoxy-2'-Substituted Purine Nucleosides. Synthesis of the Antibiotic 2'-Deoxy-2'-Aminoguanosine

Synthesis and Reaction of Nucleosides Containing Sulfur Functions in the Sugar Portion

New C-Nucleoside Isosteres of Some Nucleoside Antibiotics

Index