Chemistry and Biology of Nucleosides and Nucleotides - 1st Edition - ISBN: 9780123261403, 9780323148276

Chemistry and Biology of Nucleosides and Nucleotides

1st Edition

Editors: Robert Harmon
eBook ISBN: 9780323148276
Imprint: Academic Press
Published Date: 1st January 1978
Page Count: 490
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Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

Table of Contents

List of Contributors Preface Total Synthesis of a Bacterial Gene II: The Total DNA Including the Promotor and Its Transcription Total Synthesis of Bacterial Gene I: Chemical Synthesis of Oligonucleotides and Use of High-Pressure Liquid Chromatography The Use of Microparticulate Reversed-Phase Packing in High-Pressure Liquid Chromatography of Nucleosides Chemical and Enzymatic Methods in the Synthesis of Modified Polynucleotides Simple Models of Nucleic Acid Interactions Synthesis of Nucleotides which Inactivate Enzymes Utilizing Adenine Nucleotides Synthesis, Antiviral Activity, and Mechanism of Action of a Novel Series of Pyrimidine Nucleoside Analogs The Chemistry and Biological Activity of C-Nucleosides Related to Pseudouridine The Chemistry and Biological Activity of Certain 4-Substituted and 3,4-Disubstituted Pyrazolo (3,4-d) Pyrimidine Nucleosides The Chemistry and Biology of Some New Nucleoside Analogs Active against Tumor Cells Potentiation of the Chemotherapeutic Action of Antineoplastic Agents Coformycin and Deoxycoformycin: Tight-Binding Inhibitors of Adenoxine Deaminase Synthesis and Chemistry of a New Antiviral-Antibiotic Nucleoside in Anhydro Form: Application of a Novel 1,3-Electrophilic (C-N-C) Annulation Reagent Synthesis of 1-(2-Deoxy-ß-D-Ribofuranosyl)-5,6-Dihydro-5-Methyl-s-Triazin-2,4(1H,3H)Dione An Approach to the Synthesis of 1,9-Diribosyl Purine An Initial Study on the Selectivity and Stereospecificity of the Ribosylation Reaction On the Mechanism of Nucleoside Synthesis Synthesis and Chemistry of Certain Azole Nucleosides The Synthesis of Heterocyclic Analogs of Purine Nucleosides and Nucleotides Containing a Bridgehead Nitrogen Atom Determination of the Site of Glycosylation in Various Nucleosides by Carbon-13 NMR Spectroscopy A "Geometry-Only" 1Ή NMR Method for Determination of the Anomeric Configuration of Ribofuranosyl Compounds Investigation of Nucleoside Alkylphosphonates The Tert-Butyldimethylsilyl Group as a P


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© Academic Press 1978
Academic Press
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About the Editor

Robert Harmon

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