Chemistry and Biology of Nucleosides and Nucleotides

Chemistry and Biology of Nucleosides and Nucleotides

1st Edition - January 1, 1978

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  • Editor: Robert Harmon
  • eBook ISBN: 9780323148276

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Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

Table of Contents

  • List of Contributors


    Total Synthesis of a Bacterial Gene II: The Total DNA Including the Promotor and Its Transcription

    Total Synthesis of Bacterial Gene I: Chemical Synthesis of Oligonucleotides and Use of High-Pressure Liquid Chromatography

    The Use of Microparticulate Reversed-Phase Packing in High-Pressure Liquid Chromatography of Nucleosides

    Chemical and Enzymatic Methods in the Synthesis of Modified Polynucleotides

    Simple Models of Nucleic Acid Interactions

    Synthesis of Nucleotides which Inactivate Enzymes Utilizing Adenine Nucleotides

    Synthesis, Antiviral Activity, and Mechanism of Action of a Novel Series of Pyrimidine Nucleoside Analogs

    The Chemistry and Biological Activity of C-Nucleosides Related to Pseudouridine

    The Chemistry and Biological Activity of Certain 4-Substituted and 3,4-Disubstituted Pyrazolo (3,4-d) Pyrimidine Nucleosides

    The Chemistry and Biology of Some New Nucleoside Analogs Active against Tumor Cells

    Potentiation of the Chemotherapeutic Action of Antineoplastic Agents

    Coformycin and Deoxycoformycin: Tight-Binding Inhibitors of Adenoxine Deaminase

    Synthesis and Chemistry of a New Antiviral-Antibiotic Nucleoside in Anhydro Form: Application of a Novel 1,3-Electrophilic (C-N-C) Annulation Reagent

    Synthesis of 1-(2-Deoxy-ß-D-Ribofuranosyl)-5,6-Dihydro-5-Methyl-s-Triazin-2,4(1H,3H)Dione

    An Approach to the Synthesis of 1,9-Diribosyl Purine

    An Initial Study on the Selectivity and Stereospecificity of the Ribosylation Reaction

    On the Mechanism of Nucleoside Synthesis

    Synthesis and Chemistry of Certain Azole Nucleosides

    The Synthesis of Heterocyclic Analogs of Purine Nucleosides and Nucleotides Containing a Bridgehead Nitrogen Atom

    Determination of the Site of Glycosylation in Various Nucleosides by Carbon-13 NMR Spectroscopy

    A "Geometry-Only" 1Ή NMR Method for Determination of the Anomeric Configuration of Ribofuranosyl Compounds

    Investigation of Nucleoside Alkylphosphonates

    The Tert-Butyldimethylsilyl Group as a Protecting Group in Oligonucleotide Synthesis

    Advances in the Synthesis of C-Glycosyl Nucleosides

    Synthesis of C-Glycosyl Thiazoles

    A New Method for the Synthesis of 2'-Deoxy-2'-Substituted Purine Nucleosides. Synthesis of the Antibiotic 2'-Deoxy-2'-Aminoguanosine

    Synthesis and Reaction of Nucleosides Containing Sulfur Functions in the Sugar Portion

    New C-Nucleoside Isosteres of Some Nucleoside Antibiotics


Product details

  • No. of pages: 490
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323148276

About the Editor

Robert Harmon

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