Chemical Pathways of Metabolism

1st Edition - January 1, 1954
Editor: David M. Greenberg
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 4 2 8 - 7

Chemical Pathways of Metabolism, Volume II focuses on the chemical processes involved in the metabolism of the essential components of living organisms, including catabolism,… Read more

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Chemical Pathways of Metabolism, Volume II focuses on the chemical processes involved in the metabolism of the essential components of living organisms, including catabolism, deamination, bonds, and synthetic processes. The selection first elaborates on nitrogen metabolism and carbon catabolism of amino acids, including deamination, urea synthesis, amino acids linked with the citric acid cycle, sulfur amino acids, and arginine and ornithine. The book then ponders on the synthetic processes involving amino acids and metabolism of sulfur-containing compounds. Discussions focus on reactions of sulfur-containing coenzymes, relationships of methionine and cysteine, desulfhydrase reaction, formation of phosphatide bases, and interconversions of glutamic acid, ornithine, and proline. The manuscript takes a look at the enzymatic syntheses of peptide bonds, purines and pyrimidines, and nucleotides and nucleosides. Topics include enzymatic splitting of coenzyme nucleotides, deamination of nucleosides and nucleotides, enzymatic synthesis of coenzyme nucleotides, purines, and pyrimidines. The selection is a valuable source of information for researchers interested in the chemical pathways of metabolism.

Contributors to Volume II

List of Abbreviations and Symbols

Content of Volume I

9. Nitrogen Metabolism of Amino Acids

I. Scope

II. Deamination

III. Deamidation

IV. Transamination

V. Amino Acid Racemases

VI. Urea Synthesis

VII. Summary Remarks

Addendum

10. Carbon Catabolism of Amino Acids

I. Scope of the Chapter

II. Amino Acids Linked with the Citric Acid Cycle

III. Glycine

IV. The β-Hydroxyamino Acids

V. The Aliphatic Branched-Chain Amino Acids

VI. Certain Amino Acids of Uncertain Biological Significance

VII. The Sulfur Amino Acids

VIII. Lysine

IX. Arginine and Ornithine

X. Proline and Hydroxyproline

XI. The Aromatic Amino Acids

XII. Tryptophan

XIII. Histidine

Addenda

11. Synthetic Processes Involving Amino Acids

I. Introduction

II. The Glycine-Serine Interconversion

III. Formation of Phosphatide Bases

IV. Interconversions of Glutamic Acid, Ornithine, and Proline

V. Biosynthesis of Branched-Chain Amino Acids

VI. Lysine Biosynthesis

VII. Biosynthesis of Aromatic Amino Acids

VIII. Reactions Involving Tyrosine

IX. Synthetic Reactions Involving Tryptophan

X. Biosynthesis of Histidine

Addenda

12. Metabolism of Sulfur-Containing Compounds

I. Biologically Important Sulfur Compounds

II. Relationships of Methionine and Cysteine

III. Oxidation of Sulfur-Containing Amino Acids

IV. The Desulfhydrase Reaction

V. Thiosulfate and Thiocyanate

VI. Reactions of Sulfur-Containing Coenzymes

13. Enzymatic Syntheses of Peptide Bonds

I. Thermodynamic Considerations

II. Classification of Enzymatic Peptide Syntheses According to the Sign and Magnitude of the Free Energy Change (-△F)

III. Peptide Syntheses Where -△F Is Negative and Large: Coupled with High-Energy Phosphate

IV. Mechanism of Amino Acid Incorporation into Proteins

V. Addendum

14. Purines and Pyrimidines

I. The Purines

II. The Pyrimidines

15. Nucleotides and Nucleosides

I. Nucleosides

II. Nucleotides

III. Deamination of Nucleosides and Nucleotides

IV. The Enzymatic Splitting of Certain Coenzyme Nucleotides

V. The Enzymatic Synthesis of Certain Coenzyme Nucleotides

16. Metabolism of Heme and Chlorophyll

I. Introduction

II. Compounds of the Biosynthetic Chain Leading to the Formation of Protoporphyrin

III. Biochemical Lesions in the Porphyrin Metabolism of Human Beings

IV. Tracer Studies of Protoporphyrin Biosynthesis

V. The Iron Branch of the Biosynthetic Chain and Some General Properties of Heme Compounds

VI. The Magnesium Branch and the Biosynthesis of Chlorophyll

VII. Decomposition of Iron Protoporphyrin to Bile Pigments

Author Index

Subject Index

Errata: Volume I