
Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A
Description
Key Features
- We have selected the primary experts to write about each approach
- This provides one-stop shopping for all the means of addressing this complex question
- Anesthesia is enormously important as almost everybody receives it at some point
Readership
The scope of approaches discussed in this volume is large, ranging from how to measure changes in the movements of individual atoms, to the statistical approaches for mapping electrical activity across the whole brain. Thus, the audience is expected to consist of computational chemists, synthetic and medicinal chemists and biophysicists, physiologists, neuroscientists at all levels, neurologists, psychiatrists and, of course, anesthesiologists
Table of Contents
Computational approaches
1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics
Grace Brannigan and Sruthi Murlidaran
2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics
Vincenzo Carnevale
3. Anesthetic parameterization
Jerome Henin
4. Pharmacophore QSAR, QM, ONIOM
Edward Bertaccini
5. Kinetic modeling of electrophysiology data
Robert CantorGenetics and model organisms
6. General genetic strategies
Philip G. Morgan
7. Worms
Margaret Sedensky
8. Flies
Bruno van Swinderen
9. Tadpoles
Kellie Ann Woll
10. Zebrafish
Victoria Bedell and Julia Dallman
11. Mice
Max KelzPhotolabeling
12. Mass spect ID of adducts
Kellie Ann Woll
13. Photolabeling protection/competition
Jonathan CohenXenon
14. Xenon-protein interactions
Benjamin Roose and Ivan Dmochowski
15. Xenon gas delivery/recovery procedures
Mervyn Maze
16. Hyperpolarized Xe-129 MRI
Mitchell Albert
17. CT imaging
Andrew McKinstry-WuElectrophysiology
18. Native system electrophysiology (slices, cells, in vivo)
Boris Heifets
19. Voltage-gated ion channels (Kv, Nav)
Manuel Covarrubias and Elaine Yang
20. Ligand-gated ion channels
Stuart A. Forman
Product details
- No. of pages: 432
- Language: English
- Copyright: © Academic Press 2018
- Published: March 24, 2018
- Imprint: Academic Press
- eBook ISBN: 9780128127414
- Hardcover ISBN: 9780128127407
About the Serial Volume Editors
Roderic Eckenhoff
Affiliations and Expertise
Ivan Dmochowski
Affiliations and Expertise
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