Channelopathies of the Nervous System

1st Edition


  • Michael Rose
  • Robert Griggs
    • Print ISBN 9780750645072


    Neurologists and other neuroscientists, Pharmacologists, physiologists, geneticists and molecular biologists will find this book both a good read and a valuable reference tool.

    Table of Contents

    Part 1: Basic science (physiology, molecular biology and pharmacology): Physiology of ion channels; Molecular biology of ion channels; Pharmacology of ion channels; Part 2 Assessment of channel function (in vitro and in vivo): Techniques for assessing ion channel function; in vitro; Neurophysiological investigation of channelopathies in vivo; Part 3: Channel gene expression, and distribution and its relationship to disease and normal development: Plasticity of ion channel gene expression as a substrate for channelopathies; The role and consequences of ion channel distribution and dysfunction in pain; The role of ion channel distribution, dysfunction and gene expression in demyelinating disease; Part 4: Neuromuscular channel gene disorders (genetic): Chloride and sodium channel myotonias; The periodic paralyses: hyperkalaemic and hypokalaemic paralysis; Malignant hyperthermia; Acetylcholine receptor channelopathies and other congenital myasthenic syndromes; Part 5: Neuromuscular channel disorders (acquired): Myasthenia gravis and the Lambert Eaton syndrome; Autoimmune neuromyotonia; Part 6: Central nervous system channel disorders: Periodic and progressive ataxias; Epilepsies; Paroxysmal movement disorders as channelopathies; Hyperekplexia; Migraine: a multifactorial, neurovascular episodic channelopathy?; Part 7: Toxin-induced channel disorders: Ciguatera (fish poisoning); Part 8: Potential channel disorders: Potential channelopathies: selected myotonic disorders - Schwartz Jampel syndrome (SJS), myotonic dystrophy (DM), myotonic dystrophy type-2 (DM-2), proximal myotonic myopathy (PROMM) and proximal myotonic dystrophy (PDM); Andersen's syndrome; Part 9: Conclusion;


    No. of pages:
    © 2001
    Print ISBN:

    About the authors

    Michael Rose

    Affiliations and Expertise

    Consultant and Honorary Senior Lecturer in Neurology, King's Neurosciences Centre, King's College Hospital, and Guy's, St Thomas' and King's College School of Medicine and Dentistry, London, UK

    Robert Griggs

    Affiliations and Expertise

    Professor of Neurology, Pediatrics, Pathology and Laboratory Medicine; Center for Human Experimental Therapeutics; University of Rochester School of Medicine and Dentistry; Rochester, New York