This thematic volume provides authoritative, up-to-date reviews addressing recent advances as well as an overview for the research and clinical communities on the endemic infection of Chagas disease. Lead researchers discuss epidemiology and control measures as well as various diagnosis techniques, treatments, and therapies currently being used. The text includes a history of Chagas disease and an outlook for the next century.

Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Researchers in parasitology, tropical medicine and entomology.

Table of Contents

Contributors of Volume 76


Bioactive Lipids in Trypanosoma cruzi Infection


1.1. Introduction

1.2. Eicosanoid Synthesis in Vertebrates

1.3. Lipid Metabolism and Eicosanoid Biosynthetic Pathways in Trypanosoma cruzi

1.4. Endogenous Regulation of Eicosanoids During Experimental Chagas Disease

1.5. Lessons from Pharmacological Manipulation and from Null Mice


Mechanisms of Host Cell Invasion by Trypanosoma cruzi

2.1. Introduction

2.2. General Features of Trypanosoma cruzi Invasion

2.3. To the Lysosome … and Beyond

2.4. Disruption of the Parasitophorous Vacuole Membrane and Cytosolic Localization of Parasites

2.5. The Role of the Host Cell Cytoskeleton in Trypanosoma cruzi Trypomastigote Invasion of Non-Phagocytic Cells

2.6. The Discovery of Reversible Invasion

2.7. Concluding Remarks

Gap Junctions and Chagas Disease

3.1. Introduction

3.2. Loss of Gap Junctions and Coupling in Rodent Chagasic Cardiomyopathy

3.3. Not All Junctional Proteins are Affected by Trypanosoma cruzi Infection

3.4. Microarray Experiments have Revealed Profound Changes in Gene Expression in the Chagasic Mouse, Both in Acute and in Chronic Disease Phases

3.5. Conclusions

The Vasculature in Chagas Disease

4.1. Historical Aspects

4.2. Small Animal Studies of the Microcirculation in Trypanosoma cruzi Infection

4.3. Studies in Dogs

4.4. Vasoactive Peptides and Eicosanoids

4.5. In Vitro Studies

4.6. Studies in Humans

4.7. Conclusions


Infection-Associated Vasculopathy in Experimental Chagas Disease


5.1. Introduction

5.2. A Brief Overview on the Immunopathogenesis of Chagas Disease

5.3. Future Directions



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© 2011
Academic Press
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"One is struck by the quality and scholarship of the various chapters and the obviously efficient editing."--PARASITOLOGY
"The policy of the editors of
Advances in Parasitology to include reviews from any aspect of parasitology and the high standard of individual papers have resulted in this series of volumes becoming an indispensable source for students, teachers, and research workers."--ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY