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Central Actions of Angiotensin and Related Hormones - 1st Edition - ISBN: 9780080209333, 9781483160436

Central Actions of Angiotensin and Related Hormones

1st Edition

Editors: Joseph P. Buckley Carlos M. Ferrario Mustafa F. Lokhandwala
eBook ISBN: 9781483160436
Imprint: Pergamon
Published Date: 1st January 1977
Page Count: 624
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Central Actions of Angiotensin and Related Hormones investigates the centrally mediated actions of angiotensin and related hormones in the central nervous system (CNS). Topics covered include angiotensin I converting enzyme activity in the choroid plexus and in the retina; peptide regulation of neuronal excitability; effects of angiotensin-II and angiotensin-III on catecholamine biosynthesis; and humoral kidney mediation of adrenal catecholamine response to hemorrhage. A systems analysis of CNS-angiotensin interaction is also presented. This book is comprised of 51 chapters and opens with a discussion on the results of initial studies undertaken at the University of Pittsburgh to probe the centrally mediated hypertensive response of angiotensin II. The following chapters explore angiotensin receptor sites and angiotensin antagonists, along with the mechanisms involved in changes of blood pressure elicited by hypothalamic stimulation. The effects of angiotensin-II and angiotensin-III on the biosynthesis of catecholamines are also analyzed. The last chapter looks at recommendations regarding the nomenclature of the renin-angiotensin system, especially with respect to the extrarenal tissue enzymes. This monograph will be a valuable source of information for biochemists, biologists, physiologists, and pharmacologists.

Table of Contents


List of Participants

Initial Studies on the Central Nervous System Effects of Angiotensin II

Angiotensin Receptor Sites

Angiotensin Antagonists

Angiotensin I Converting Enzyme Activity in the Choroid Plexus and in the Retina

Peptide Regulation of Neuronal Excitability: Evidence for a Neurohormonal Role

Mechanisms Involved in Changes of Blood Pressure Elicited by Hypothalamic Stimulation

Renin Substrate in the CNS: Potential Significance to Central Regulatory Mechanisms


Open Discussion I

Angiotensin and Sympathetic Activity

Effects of Angiotensin-II and Angiotensin-III on Catecholamine Biosynthesis

Humoral Kidney Mediation of Adrenal Catecholamine Response to Hemorrhage

The Role of Efferent and Afferent Renal Nerves in the Release of Renin in the Cat

Renal Adrenergic Effect of Angiotensin


Physiologic Effects of the Renin-Angiotensin System on Sympathetic Nervous System Activity in the Conscious Dog

Open Discussion II

A Central Site of Action of Angiotensin II and Its Possible Role in the Central Regulation of the Cardiovascular System

A Technique for Determining the Site of Action of Angiotensin and Other Hormones in the Brain Stem

The Regulation of Vasomotor Centre Activity by Angiotensin


Open Discussion III

Systems Analysis of CNS/Angiotensin Interaction

Direct and Centrally Mediated Cardiovascular Activity of Angiotensin III

Interaction of Angiotensin II with Central Adrenergic Receptors

Further Studies on Centrally Mediated Hemodynamic Effects of Angiotensin II in Anesthetized Cats

Studies on the Interaction of Clonidine with the Hypertensive Activity of Angiotensin II

Presence and Significance of Angiotensin in Cerebrospinal Fluid

Immunopharmacology of Angiotensin I in Brain


Open Discussion IV

Hypothalamic Stimulation of ADH Release by Angiotensin II

Interactions and Properties of Some Components of the Renin-Angiotensin System in Brain

Inhibitors of the Renin-Angiotensin System in Rats with Malignant and Spontaneous Hypertension: Comparative Anti-Hypertensive Effects of Central vs. Peripheral Administration

Evidence for a Potentiating Effect of Circulating Angiotensin in the Osmotically Stimulated Increase in Plasma Antidiuretic Hormone Concentration


The Role of ADH in the Pressor Response to Intraventricular Angiotensin II

Drinking Elicited by Angiotensin or Hyperosmotic Stimulation of the Rat Antero-Ventral Third Ventricle: Single or Separate Neural Substrates?

Open Discussion V

Sensitive Sites in the Brain for the Blood Pressure and Drinking Responses to Angiotensin II

A Critical Analysis of the Site of Action for the Dipsogenic Effect of Angiotensin II


Open Discussion VI

Copious Drinking and the Renin-Angiotensin-System

The Peptide Specificity of Receptors for Angiotensin-Induced Thirst

Suppression of Angiotensin-Induced Thirst by the E-Prostaglandins

Angiotensin II-Induced Drinking: Distribution of Responsive Central Tissue Sites in the Rat, Rabbit and Monkey

Localization of Dipsogenic Receptors for Angiotensin II


Free Water Clearance Decrease after Intracarotid (ICA) Angiotensin II (A-II) in Conscious Sheep

Open Discussion VII

Central Sodium-Angiotensin Interaction

Effects of Changing CSF-NaCl Concentration on Renal Function, Renin, Angiotensin, and Aldosterone

Evidence for Multiple Receptors and Neural Pathways Which

Multiple Kidney Renins Associated with Malignant Hypertension


Open Discussion VIII

Immunohistochemical Evidence for the Existence of Angiotensin II Containing Nerve Terminals in the Central Nervous System of the Rat

On the Origin of Angiotensin-Like Peptides in Cerebrospinal Fluid

Effects of Centrally Administered Angiotensin II and Angiotensin II Antagonist on Arterial Blood Pressure in Different Strains of Rats

Lack of Hypotensive Effect of Central Injection of Angiotensin Inhibitors in SH and Normotensive Rats

Some Central Nervous System Effects on the Circulating Angiotensin-Converting Enzyme

Binding of Angiotensins by Plasma Factors from Mentally Retarded Patients, by Phospholipids Found in Nervous Tissue, and by Cells of the Retina

Angiotensin I and Dopamine-e-Hydroxylase in the Cerebrospinal Fluid of Normotensive and Hypertensive Patients

On the Neuronal Localization and the Physiological Variations of Brain Angiotensin

The Interaction of Angiotensin II with Mast Cells, Platelets and 5-HT Neurons


Open Discussion IX

Recommendations for Nomenclature of the Renin-Angiotensin System



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© Pergamon 1977
1st January 1977
eBook ISBN:

About the Editors

Joseph P. Buckley

Carlos M. Ferrario

Mustafa F. Lokhandwala

Ratings and Reviews