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Epigenetic Regulation of Gene Expression in Human Cells by Noncoding RNAs
I. Introduction to ncRNA
II. Epigenetics and ncRNAs
III. Long Intergenic Noncoding RNAs and Epigenetic Control of Gene Transcription
Small RNA-Induced Transcriptional Gene Regulation in Mammals
II. Mammalian Small RNA Biogenesis Pathways
III. Mechanisms of Small RNA-Induced Transcriptional Regulation
IV. Therapeutic Application of TGS
V. The Scope of TGS Therapeutics
MicroRNA Function in the Nervous System
II. miRNAs in Neural Differentiation
III. miRNAs in Postmitotic Neurons
IV. The Roles of miRNA in Neurological Diseases
The Role of MicroRNAs in Viral Infection
II. Regulation of miRNAs and Their Association with Disease
III. Introduction to Viral Infection
IV. Viral miRNAs
V. Regulation of Cellular miRNAs by Viral Infection
VI. Regulation of Viruses by Cellular miRNAs
Toward a Durable Treatment of HIV-1 Infection Using RNA Interference
I. RNAi: From Natural Pathway to Therapeutic Method
II. Antiviral RNAi Strategies: Toward a Gene Therapy for HIV-1
III. Where to Target the HIV-1 RNA Genome?
IV. Combinatorial RNAi Approaches
V. Targeting Cellular Cofactors of HIV-1 Replication
VI. Preclinical Test Systems and Safety Concerns
VII. Safety Issues Raised in Clinical Trials
VIII. Gene Therapy Trials for HIV-AIDS
When Cellular Networks Run Out of Control
I. Introduction: Quis Custodiet Ipsos Custodes or Who Watches the Watchmen?
II. Control of Individual miRNAs and RNAi Components
III. Global Dysregulation of Key RNAi Factors in Human Disease
IV. Quantitative Interference of Viruses with Host RNAi Factors
V. Adverse Effects in Gene/RNAi Therapy Studies
VI. Outlook: Relevance for Molecular Biology and Clinical Translation of RNAi
This volume explores some of the most exciting recent advances in basic research on cellular RNA interference mechanisms and how this knowledge is leading to advances in the various fields.
- This series provides a forum for discussion of new discoveries, approaches, and ideas
- Contributions from leading scholars and industry experts
- Reference guide for researchers involved in molecular biology and related fields
Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.
- No. of pages:
- © Academic Press 2011
- 26th August 2011
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal
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