Cellular RNA Interference Mechanisms

Cellular RNA Interference Mechanisms

1st Edition - August 12, 2011

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  • Editor: Dirk Grimm
  • Hardcover ISBN: 9780124157958
  • eBook ISBN: 9780124158610

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This volume explores some of the most exciting recent advances in basic research on cellular RNA interference mechanisms and how this knowledge is leading to advances in the various fields.

Key Features

  • This series provides a forum for discussion of new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • Contributors


    Epigenetic Regulation of Gene Expression in Human Cells by Noncoding RNAs

    I. Introduction to ncRNA

    II. Epigenetics and ncRNAs

    III. Long Intergenic Noncoding RNAs and Epigenetic Control of Gene Transcription

    Small RNA-Induced Transcriptional Gene Regulation in Mammals

    I. Introduction

    II. Mammalian Small RNA Biogenesis Pathways

    III. Mechanisms of Small RNA-Induced Transcriptional Regulation

    IV. Therapeutic Application of TGS

    V. The Scope of TGS Therapeutics

    VI. Conclusions

    MicroRNA Function in the Nervous System

    I. Introduction

    II. miRNAs in Neural Differentiation

    III. miRNAs in Postmitotic Neurons

    IV. The Roles of miRNA in Neurological Diseases

    The Role of MicroRNAs in Viral Infection

    I. Introduction

    II. Regulation of miRNAs and Their Association with Disease

    III. Introduction to Viral Infection

    IV. Viral miRNAs

    V. Regulation of Cellular miRNAs by Viral Infection

    VI. Regulation of Viruses by Cellular miRNAs

    VII. Conclusions

    Toward a Durable Treatment of HIV-1 Infection Using RNA Interference

    I. RNAi: From Natural Pathway to Therapeutic Method

    II. Antiviral RNAi Strategies: Toward a Gene Therapy for HIV-1

    III. Where to Target the HIV-1 RNA Genome?

    IV. Combinatorial RNAi Approaches

    V. Targeting Cellular Cofactors of HIV-1 Replication

    VI. Preclinical Test Systems and Safety Concerns

    VII. Safety Issues Raised in Clinical Trials

    VIII. Gene Therapy Trials for HIV-AIDS

    IX. Conclusion

    When Cellular Networks Run Out of Control

    I. Introduction: Quis Custodiet Ipsos Custodes or Who Watches the Watchmen?

    II. Control of Individual miRNAs and RNAi Components

    III. Global Dysregulation of Key RNAi Factors in Human Disease

    IV. Quantitative Interference of Viruses with Host RNAi Factors

    V. Adverse Effects in Gene/RNAi Therapy Studies

    VI. Outlook: Relevance for Molecular Biology and Clinical Translation of RNAi


Product details

  • No. of pages: 261
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: August 12, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124157958
  • eBook ISBN: 9780124158610

About the Serial Volume Editor

Dirk Grimm

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