Cellular Migration and Formation of Neuronal Connections

1st Edition

Comprehensive Developmental Neuroscience

Print ISBN: 9780123972668
eBook ISBN: 9780123973474
Imprint: Academic Press
Published Date: 24th May 2013
Page Count: 1080
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The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns.

Key Features

  • Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop
  • Features leading experts in various subfields as Section Editors and article Authors
  • All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
  • Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity.


Neuroscience, developmental biology researchers, including stem cells, aging and diseases. Translational neuroscience researchers - many neurodegeneration diseases (Alzheimers!) have their roots in mechanisms studied in development, and many psychiatric diseases (Autism!) are consequences of developmental problems (Rubenstein is Prof Psychiatry)

Table of Contents

Brain Development: Normal Mechanisms and Disease Mechanisms

Preliminary structure - details to be confirmed in planning meeting. Section editor candidates in brackets (* with those that have been talked to already)

1. Section 1 - Principles (Chris Doe, Luis Puelles)
2. Section: Generation of Cell Types (David Anderson, Francois Guillemot, Tom Jessell, Chris Doe)
3. Section: Migration (Joe Gleensen, LW Tsai, Oscar Marin, Chris Walsh)
4. Section: Formation of Axons and Dendrites (Marc Tessier-Lavigne, F. Polleux, YN Jan)
5. Section: Synaptogenesis (Jeff Lichtman, Josh Sanes)
6. Section: Differentiation of Electrical Properties (Y Ben-Ari, Roger Nicol)
7. Section: Glia, Bloodvessels, Choroid Plexus, Immune Cells (Ben Barres)
8. Section: Circuit Development (Takao Hensch, Michael Styker, Carla Shatz)
9. Section: Cognitive Development (Adele Diamond, Torkel Klingberg, Tomas Paus)
10. Section: Cell Cycle (tbd)
11. Section: Cell Death (tbd)


No. of pages:
© Academic Press 2013
Academic Press
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"This…second of a three volume series…is intended to summarize the current state of developmental neuroscience. There are four sections with Rubenstein and Rakic as chief editors and each section having a section editor in charge of peer reviewing the articles therein. Section I is an overview of neuron development…The second section is on neuron migration during brain development…Section III is on synaptogenesis…The fourth section demonstrates the ways that the ongoing synaptic activity of the brain and not simply genetics mediates brain development."--Reference & Research Book News, December 2013