Cellular Energy Metabolism and its Regulation - 1st Edition - ISBN: 9780120661503, 9780323138765

Cellular Energy Metabolism and its Regulation

1st Edition

Authors: Author Unknown
eBook ISBN: 9780323138765
Imprint: Academic Press
Published Date: 28th September 1977
Page Count: 293
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Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book deals with some aspects of metabolism from that point of view. The key concepts discussed include the conservation of solvent capacity and energy; functional stoichiometric coupling and metabolic prices; adenylate control and the adenylate energy charge; aspects of enzyme behavior that appear to be related to metabolic control; interactions between metabolic sequences; and the adenylate energy charge in intact cells. This book was designed for graduate students in biochemistry, physiology, microbiology, and related fields. However, it may also be useful to senior undergraduate students and more advanced workers who have a direct or peripheral interest in energy metabolism. It assumes a general familiarity with the material covered in a standard biochemistry textbook as well as some knowledge of such related areas as genetics.

Table of Contents


1 Introduction: Evolutionary Design

2 Conservation of Solvent Capacity and of Energy

Conservation of Solvent Capacity

Conservation of Energy


3 Functional Stoichiometric Coupling and Metabolic Prices

Functional Coupling

Types of Metabolic Stoichiometries

The ATP Equivalent


Metabolic Costs of Growth


4 Adenylate Control and the Adenylate Energy Charge

Kinetic Control of Metabolism

The Adenylate Energy Charge

Roles of Adenylates in Metabolism


5 Enzymes as Control Elements

Single or Noninteracting Sites

Interacting Sites and Cooperativity

Graphical Representation of Enzyme Responses

Basis of Cooperativity

Binding Energies and Enzyme Action


6 Interactions between Regulatory Parameters

Amphibolic Sequences

Anabolic Sequences

Interactions between Sequences


7 The Adenylate Energy Charge in Intact Cells

Stability of Concentrations and Concentration Ratios

Energy Charge, Adenylate Pool, and Functional Capacities


8 General Summary and Discussion

Appendix A Some Elementary Aspects of Thermodynamics

The First Law of Thermodynamics

The Second Law of Thermodynamics

Appendix B "High-Energy Bonds," Thermodynamics, and Open Systems

Appendix C The Briggs-Haldane Treatment




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© Academic Press 1977
Academic Press
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