Cellular Basis of Chemical Messengers in the Digestive System

Cellular Basis of Chemical Messengers in the Digestive System

1st Edition - January 1, 1981

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  • Editor: Morton Grossman
  • eBook ISBN: 9780323153355

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Cellular Basis of Chemical Messengers in the Digestive System contains the proceedings of an international symposium on the cellular basis of chemical messengers of the digestive system held in Santa Monica, California, on January 16, 17, and 18, 1980. The papers explore the entire spectrum of problems related to the cellular aspects of chemical messengers in the digestive system, with emphasis on which amines and peptides serve these functions and in which neurons and endocrine-paracrine cells each kind of chemical messenger is found. This book is comprised of 28 chapters divided into six sections and begins by considering the nature of gut peptides and their possible functions. The discussion then turns to the diffuse neuroendocrine system and the phylogeny of the gastroenteropancreatic neuroendocrine system. Methods such as immunocytochemistry, electron immunohistochemistry, and electron microscopy autoradiography are then described. The following chapters focus on the function and morphology of endocrine-paracrine cells; immunochemical characterization of peptides in endocrine cells and nerves; Langerhans islets as the neuro-paraneuronal control center of the exocrine pancreas; and regulation of metabolism by gastroenteropancreatic peptides. The final section presents experimental results, including in vitro studies of canine pseudo-islets and of the mechanism of gastrin release. This monograph will be of interest to physiologists and other practitioners in the field of medicine.

Table of Contents

  • List of Contributors and Participants


    Other Titles in the Series

    Introductory Topics

    Nature of Gut Peptides and Their Possible Functions

    The Diffuse Neuroendocrine System: Falsification and Verification of a Concept

    Phylogeny of the Gastroenteropancreatic Neuroendocrine System: A Review

    Membrane Recycling in Secretory Cells: Existence of Multiple Pathways Involving Golgi Cisternae, Secretory Granules, and Lysosomes


    Use of EM Autoradiography and Organ Culture to Identify Pathways of Amine Synthesis in Human and Murine Gastric Endocrine Cells

    Immunocytochemistry of Secretory Peptides: Introduction of a New Immunocytochemical Technique

    Electron Immunohistochemistry of Gut Peptides in Tissues Processed for Routine Electron Microscopy

    Immunocytochemical Investigations of the Gastroenteropancreatic Endocrine Cells Using Semithin and Thin Serial Sections

    Structural and Functional Classification: Endocrine-Paracrine Cells

    Function and Morphology in Gastric Endocrine Cells

    Heterogeneity of the D1 Cell

    Ultrastructural Identification of TG Cells in Man and Monkey

    Neurotensin in the Central Nervous System, Gastrointestinal Tract, and Plasma: Its Isolation and Chemical Characterization

    Multiple Secretory Messengers in Endocrine Cells and Neurons: ACTH-Related and Opioid Peptides in Gut and Brain

    Human Gastroenteropancreatic Endocrine-Paracrine Cells: Santa Monica 1980 Classification

    Structural and Functional Classification: Nerves

    P-Type Nerves: Purinergic or Peptidergic

    Polarity and Projections of Peptide-Containing Neurons in the Guinea Pig Small Intestine

    Immunochemical Characterization of Peptides in Endocrine Cells and Nerves with Particular Reference to Gastrin and Cholecystokinin

    Langerhans Islets as the Neuro-Paraneuronal Control Center of the Exocrine Pancreas

    Classification of Gastroenteropancreatic Nerves

    Pathological Aspects

    Regulation of Metabolism by Gastroenteropancreatic Peptides

    Evidence for Neurohormonal Peptides in Ovarian Carcinoids: A Preliminary Report of Immunohistochemical Findings

    Distribution, Origin, and Pathology of the Gut Peptidergic Innervation

    Experimental Aspects

    Storage and Release of Serotonin and Serotonin-Binding Protein by Serotonergic Neurons

    Distribution and Release of Peptides from Peripheral Neurons

    Experimentally Induced Endocrine Pancreatic Tumors in the Rat

    In Vitro Studies of Canine Pseudo-Islets

    In Vitro Gastrin Release by Rat Antrum: Effects of Exogenous Prostaglandins

    In Vitro Studies of the Mechanism of Gastrin Release: Comparison of the Results between Isolated G-Cell and Organ Culture Preparations

    Author Index

    Subject Index

Product details

  • No. of pages: 378
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 1, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323153355

About the Editor

Morton Grossman

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