Cellular Basis of Chemical Messengers in the Digestive System - 1st Edition - ISBN: 9780123044204, 9780323153355

Cellular Basis of Chemical Messengers in the Digestive System

1st Edition

Editors: Morton Grossman
eBook ISBN: 9780323153355
Imprint: Academic Press
Published Date: 1st January 1981
Page Count: 378
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Cellular Basis of Chemical Messengers in the Digestive System contains the proceedings of an international symposium on the cellular basis of chemical messengers of the digestive system held in Santa Monica, California, on January 16, 17, and 18, 1980. The papers explore the entire spectrum of problems related to the cellular aspects of chemical messengers in the digestive system, with emphasis on which amines and peptides serve these functions and in which neurons and endocrine-paracrine cells each kind of chemical messenger is found. This book is comprised of 28 chapters divided into six sections and begins by considering the nature of gut peptides and their possible functions. The discussion then turns to the diffuse neuroendocrine system and the phylogeny of the gastroenteropancreatic neuroendocrine system. Methods such as immunocytochemistry, electron immunohistochemistry, and electron microscopy autoradiography are then described. The following chapters focus on the function and morphology of endocrine-paracrine cells; immunochemical characterization of peptides in endocrine cells and nerves; Langerhans islets as the neuro-paraneuronal control center of the exocrine pancreas; and regulation of metabolism by gastroenteropancreatic peptides. The final section presents experimental results, including in vitro studies of canine pseudo-islets and of the mechanism of gastrin release. This monograph will be of interest to physiologists and other practitioners in the field of medicine.

Table of Contents

List of Contributors and Participants Preface Other Titles in the Series Introductory Topics Nature of Gut Peptides and Their Possible Functions The Diffuse Neuroendocrine System: Falsification and Verification of a Concept Phylogeny of the Gastroenteropancreatic Neuroendocrine System: A Review Membrane Recycling in Secretory Cells: Existence of Multiple Pathways Involving Golgi Cisternae, Secretory Granules, and Lysosomes Methods Use of EM Autoradiography and Organ Culture to Identify Pathways of Amine Synthesis in Human and Murine Gastric Endocrine Cells Immunocytochemistry of Secretory Peptides: Introduction of a New Immunocytochemical Technique Electron Immunohistochemistry of Gut Peptides in Tissues Processed for Routine Electron Microscopy Immunocytochemical Investigations of the Gastroenteropancreatic Endocrine Cells Using Semithin and Thin Serial Sections Structural and Functional Classification: Endocrine-Paracrine Cells Function and Morphology in Gastric Endocrine Cells Heterogeneity of the D1 Cell Ultrastructural Identification of TG Cells in Man and Monkey Neurotensin in the Central Nervous System, Gastrointestinal Tract, and Plasma: Its Isolation and Chemical Characterization Multiple Secretory Messengers in Endocrine Cells and Neurons: ACTH-Related and Opioid Peptides in Gut and Brain Human Gastroenteropancreatic Endocrine-Paracrine Cells: Santa Monica 1980 Classification Structural and Functional Classification: Nerves P-Type Nerves: Purinergic or Peptidergic Polarity and Projections of Peptide-Containing Neurons in the Guinea Pig Small Intestine Immunochemical Characterization of Peptides in Endocrine Cells and Nerves with Particular Reference to Gastrin and Cholecystokinin Langerhans Islets as the Neuro-Paraneuronal Control Center of the Exocrine Pancreas Classification of Gastroenteropancreatic Nerves Pathological Aspects R


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© Academic Press 1981
Academic Press
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About the Editor

Morton Grossman

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