Cellular Basis of Chemical Messengers in the Digestive System

1st Edition - January 1, 1981
Editor: Morton Grossman
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 3 3 5 - 5

Cellular Basis of Chemical Messengers in the Digestive System contains the proceedings of an international symposium on the cellular basis of chemical messengers of the digestive… Read more

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Cellular Basis of Chemical Messengers in the Digestive System contains the proceedings of an international symposium on the cellular basis of chemical messengers of the digestive system held in Santa Monica, California, on January 16, 17, and 18, 1980. The papers explore the entire spectrum of problems related to the cellular aspects of chemical messengers in the digestive system, with emphasis on which amines and peptides serve these functions and in which neurons and endocrine-paracrine cells each kind of chemical messenger is found. This book is comprised of 28 chapters divided into six sections and begins by considering the nature of gut peptides and their possible functions. The discussion then turns to the diffuse neuroendocrine system and the phylogeny of the gastroenteropancreatic neuroendocrine system. Methods such as immunocytochemistry, electron immunohistochemistry, and electron microscopy autoradiography are then described. The following chapters focus on the function and morphology of endocrine-paracrine cells; immunochemical characterization of peptides in endocrine cells and nerves; Langerhans islets as the neuro-paraneuronal control center of the exocrine pancreas; and regulation of metabolism by gastroenteropancreatic peptides. The final section presents experimental results, including in vitro studies of canine pseudo-islets and of the mechanism of gastrin release. This monograph will be of interest to physiologists and other practitioners in the field of medicine.

List of Contributors and Participants

Preface

Other Titles in the Series

Introductory Topics

Nature of Gut Peptides and Their Possible Functions

The Diffuse Neuroendocrine System: Falsification and Verification of a Concept

Phylogeny of the Gastroenteropancreatic Neuroendocrine System: A Review

Membrane Recycling in Secretory Cells: Existence of Multiple Pathways Involving Golgi Cisternae, Secretory Granules, and Lysosomes

Methods

Use of EM Autoradiography and Organ Culture to Identify Pathways of Amine Synthesis in Human and Murine Gastric Endocrine Cells

Immunocytochemistry of Secretory Peptides: Introduction of a New Immunocytochemical Technique

Electron Immunohistochemistry of Gut Peptides in Tissues Processed for Routine Electron Microscopy

Immunocytochemical Investigations of the Gastroenteropancreatic Endocrine Cells Using Semithin and Thin Serial Sections

Structural and Functional Classification: Endocrine-Paracrine Cells

Function and Morphology in Gastric Endocrine Cells

Heterogeneity of the D1 Cell

Ultrastructural Identification of TG Cells in Man and Monkey

Neurotensin in the Central Nervous System, Gastrointestinal Tract, and Plasma: Its Isolation and Chemical Characterization

Multiple Secretory Messengers in Endocrine Cells and Neurons: ACTH-Related and Opioid Peptides in Gut and Brain

Human Gastroenteropancreatic Endocrine-Paracrine Cells: Santa Monica 1980 Classification

Structural and Functional Classification: Nerves

P-Type Nerves: Purinergic or Peptidergic

Polarity and Projections of Peptide-Containing Neurons in the Guinea Pig Small Intestine

Immunochemical Characterization of Peptides in Endocrine Cells and Nerves with Particular Reference to Gastrin and Cholecystokinin

Langerhans Islets as the Neuro-Paraneuronal Control Center of the Exocrine Pancreas

Classification of Gastroenteropancreatic Nerves

Pathological Aspects

Regulation of Metabolism by Gastroenteropancreatic Peptides

Evidence for Neurohormonal Peptides in Ovarian Carcinoids: A Preliminary Report of Immunohistochemical Findings

Distribution, Origin, and Pathology of the Gut Peptidergic Innervation

Experimental Aspects

Storage and Release of Serotonin and Serotonin-Binding Protein by Serotonergic Neurons

Distribution and Release of Peptides from Peripheral Neurons

Experimentally Induced Endocrine Pancreatic Tumors in the Rat

In Vitro Studies of Canine Pseudo-Islets

In Vitro Gastrin Release by Rat Antrum: Effects of Exogenous Prostaglandins

In Vitro Studies of the Mechanism of Gastrin Release: Comparison of the Results between Isolated G-Cell and Organ Culture Preparations

Author Index

Subject Index