Cellular and Molecular Renewal in the Mammalian Body

1st Edition - January 1, 1971
Editors: Ivan L. Cameron, Jack D. Thrasher
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 1 3 8 - 5

Cellular and Molecular Renewal in the Mammalian Body concerns the dynamic nature of body constituents at the molecular, organelle, and cellular level of structural organization.… Read more

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Cellular and Molecular Renewal in the Mammalian Body concerns the dynamic nature of body constituents at the molecular, organelle, and cellular level of structural organization. Each chapter of this book deals with cellular and molecular renewal, proliferation, and loss, focusing on the body's major macromolecular classes, such as DNA, RNA, proteins, lipids, and carbohydrates. Other topics discussed include the subcellular renewal, DNA stability, regulation of cell proliferation, and changes in mitotic rates. The intracellular sites of RNA synthesis, proteins of the nucleus, and epithelial-mesenchymal interactions are also elaborated. This text likewise covers the brown adipose tissue, histochemistry of polysaccharides, and calcification. This publication is beneficial to students and investigators intending to acquire knowledge of the dynamic nature of body constituents and its influence to the analysis and experimentation of normal, disease, and repair processes within the body.

List of Contributors

Preface

1. Approaches to the Study of Molecular and Cellular Renewal

I. Introduction

II. Cell Populations and Renewal

III. Subcellular Renewal

References

2. The Metabolic Stability of Nuclear DNA

I. Introduction

II. DNA Constancy

III. DNA Stability

IV. Conclusions

References

3. Cell Proliferation and Renewal in the Mammalian Body

I. Introduction

II. Cell Proliferation and Growth during the Embryonic and Postnatal Periods

III. Methods Used to Visualize and to Measure Cell Proliferation and Cell Renewal

IV. Classification of Cell Populations Based on Their Proliferative Behavior

V. Regulation of Cell Proliferation

References

4. Cellular Content and Cellular Proliferation Changes in the Tissues and Organs of the Aging Mammal

I. Introduction

II. Changes in Numbers of Cells and Nerve Fibers

III. Changes in Mitotic Rates

IV. Changes in Mucosal Cells of the Intestine

V. Discussion

References

5. RNA Molecules in Cells and Tissues, In Vivo and In Vitro

I. Introduction

II. Intracellular Sites of RNA Synthesis

III. Nuclear Sites of RNA Synthesis

IV. The Biosynthesis of RNA Molecules

V. Nucleic Acids of Mitochondria

VI. RNA Synthesis in Special Cell Systems

VII. RNA Synthesis over the Cell Cycle

References

6. Turnover of Intracellular Proteins

I. Introduction

II. Proteins of the Nucleus

III. Turnover of Proteins in Cytoplasmic Systems

IV. Proteins and the Cell Cycle

V. Protein Metabolism in Special Cell Systems

References

7. The Dynamics of Extracellular and Cell Surface Protein Interactions

I. Introduction

II. Epigenetic Controls Regulating Differentiation: The Problem

III. Outer Cell Surface Properties and Their Role in the Formation of Metazoan Systems

IV. Epithelial-Mesenchymal Interactions

V. The Extracellular Matrix Influences upon Cellular Differentiation

References

8. Synthesis, Localization, and Renewal of Lipids in Mammalian Tissues

I. Introduction

II. Fatty Acids and Triglycerides

III. Cholesterol

IV. Sphingolipids

V. Phospholipids

VI. Brown Adipose Tissue

VII. Summary

References

9. Localization, Identification, and Renewal of Carbohydrates in Tissues and Cells

I. Introduction

II. Histochemistry of Mucins

III. Histochemistry of Polysaccharides

References

10. Calcification

Text

References

Author Index

Subject Index