Cell Press Reviews: Cancer Therapeutics - 1st Edition - ISBN: 9780124201927, 9780127999173

Cell Press Reviews: Cancer Therapeutics

1st Edition

Paperback ISBN: 9780124201927
eBook ISBN: 9780127999173
Imprint: AP Cell
Published Date: 17th December 2013
Page Count: 322
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Table of Contents

About Cell Press

Contributors

Preface

Chapter 1. The Evolving War on Cancer

Acknowledgments

Summary

Introduction

Breaking the Cancer War Stalemate

Drawing from Somatic Cancer Genetics to Find Therapeutic Targets

Challenging Medicinal Chemistry to Design New Classes of Inhibitors

Redesigning Cancer Clinical Trials: Genotype First, Monitor in Real Time

The Next Steps in the War on Cancer

References

Chapter 2. Can We Deconstruct Cancer, One Patient at a Time?

Acknowledgments

Summary

Cancer Treatment in the Age of Omics

Cancer as a Black Box

Deconstructing Cancer, One Patient at a Time

The Road Ahead

Concluding Remarks

References

Chapter 3. The Genetic Basis for Cancer Treatment Decisions

Acknowledgments

Summary

Introduction

Framework Requirements for Evaluating the Genetic Basis for Cancer Treatment

Patient Recruitment and Informed Consent

Tissue Requirements: Quantity, Quality, Processing, and Timing

Genomic Technologies and Data Management

Reporting Data to Clinicians and Patients

Monitoring and Evaluating the Utility of Clinical Genomics

Data Sharing

Implications for Drug Development

Implications for Regulatory Bodies

Implications for Patients, Healthcare Providers, and Payers

Conclusions

References

Chapter 4. Cancer Epigenetics: From Mechanism to Therapy

Acknowledgments

Summary

Introduction

Characterizing the Epigenome

Epigenetics and the Cancer Connection

Epigenetic Pathways Connected to Cancer

Perspective and Conclusions

References

Chapter 5. Converting Cancer Therapies into Cures: Lessons from Infectious Diseases

Acknowledgments

Summary

Introduction

Mutationa


Description

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including:

  • Genetic approaches for personal oncology
  • Targeting epigenetic dysregulation and protein interaction networks
  • Vaccines and antibodies in cancer immunotherapy
  • Tumor heterogeneity and chemotherapy resistance
  • Tumor associated macrophages in anticancer treatment

Contributions come from leading voices in the field, including:
- Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School
- Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics
- Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences

Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

Key Features

  • Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics
  • Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy
  • Features reviews on basic science advances translated into drug discovery and therapeutic approaches
  • Includes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences

Readership

Academic, medical researchers, and students in cancer biology, and cancer prevention/therapeutics, including cell biologists, biological chemists, geneticists, pharmacologists, oncologists, and radiation oncologists.


Details

No. of pages:
322
Language:
English
Copyright:
© AP Cell 2014
Published:
Imprint:
AP Cell
eBook ISBN:
9780127999173
Paperback ISBN:
9780124201927

Reviews

"...offers the most up-to-date insights into how genetics influences treatnent decisions and how the immune system can be employed to battle cancer, and describes the current state-of-the-art in drug discovery and targeted treatments." --Anticancer Research, January 2015