Cell Interactions in Differentiation

1st Edition - January 1, 1977
Editor: Marketta Karkinen-Jaaskelainen
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 0 5 5 - 2

Cell Interactions in Differentiation is a collection of papers presented at the Sixth Sigrid Jusélius Foundation Symposium held in Helsinki, Finland, in August 1976. Contributors… Read more

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Cell Interactions in Differentiation is a collection of papers presented at the Sixth Sigrid Jusélius Foundation Symposium held in Helsinki, Finland, in August 1976. Contributors discuss cell interactions during differentiation, particularly referring to the problem of embryonic induction. They also consider how a cell becomes adjusted to the synchronized development of an entire multicellular organism, so as to express its genetic information at a strictly controlled time and place. This volume is organized into five sections encompassing 30 chapters and begins with an overview of embryonic cells and their two fundamental properties. Cells are not necessarily predetermined and can be experimentally diverted from their normal developmental pathway, and those within an embryonic organism require extrinsic messages to express their developmental capacities. The next chapters focus on early determinative events in embryogenesis, touching on topics such as the genetic aspects of cell type determination, interactions between embryonic cells during the early development of the mouse, and the differentiation of teratocarcinoma stem cells in vitro. The reader is then introduced to positional information and morphogenetic signals; the biological ""specificity"" of morphogenetic tissue interactions; and the molecular mechanisms underlying cell contact interactions. The remaining chapters explore some of the most important conceptual and methodological approaches to the problems of cell-cell recognition and the integration of cells into multicellular systems. This book will be of interest to scientists and investigators in developmental biology and related fields.

List of Participants

Preface

Opening Remarks

Introduction

I. Early Determinative Events in Embryogenesis

Early Determinative Events in Embryogenesis: An Introduction

Analysis of a Cytoplasmic Determinant in a Insect Egg

Genetics of Cell Type Determination

Interactions between Embryonic Cells during the Early Development of the Mouse

The Differentiation of Teratocarcinoma Stem Cells in vitro: Parallels to Normal Embryogenesis

II. Positional Information and Morphogenese Signals

Positional Information and Morphogenetic Signals: An Introduction

Compartments in the Development of Drosophila: A Progress Report

Positional Signalling and Nerve Cell Specificity

Organizing Principles for Anatomical Patterns and for Selective Nerve Connections in the Developing Amphibian Brain

Regulation of Proximo-distal Pattern Formation in the Developing Limb

III. Morphogenetic Tissue Interactions

Embryonic Induction: An Historical Note

Morphogenetic Tissue Interactions: An Introduction

Tissue Interactions in Amniote Skin Development

The Differentiation of the Ganglioblasts of the Autonomic Nervous System Studied in Chimeric Avian Embryos

Tissue Interactions in Tooth Development in vitro

Epigenetic Regulation of Enamel Protein Synthesis during Epithelial- Mesenchymal Interactions

Studies on Primary Embryonic Induction

Kidney Tubule Induction: Physical and Chemical Interference

Stimulation of Chondrogenic Differentiation with Extracellular Matrix Components: A n Analysis using Scanning Electron Microscopy

IV. Molecular Mechanisms of Cell Contact Interactions

Molecular Mechanisms of Cell Contact Interactions: An Introduction

Some Biophysical Aspects of Cell Contact, Detachment and Movement

Some Chemical Bases for Biological Specificity as Exemplified by Hapten-Antibody Interactions

Interactions of Fibronectin, a Cell-Type Specific Surface-Associated Glycoprotein

Gap Junctions and Cell Contacts

The Molecular Basis of the Mesenchymal-Epithelial Interactions in Pancreatic Development

V. Cell Recognition

Cell Recognition: An Introduction

Mechanisms of Cell-Cell Recognition: Some Comparisons between Lower Organisms and Vertebrates

Periodic Cyclic-AMP Signals and Membrane Differentiation in Dictyostelium

Developmental Interactions Studied with Experimental Teratomas derived from Mutants at the T/t Locus in the Mouse

Self-recognition Phenomenon in Acquired Immunity

Subject Index