Cell Interactions in Differentiation is a collection of papers presented at the Sixth Sigrid Jusélius Foundation Symposium held in Helsinki, Finland, in August 1976. Contributors discuss cell interactions during differentiation, particularly referring to the problem of embryonic induction. They also consider how a cell becomes adjusted to the synchronized development of an entire multicellular organism, so as to express its genetic information at a strictly controlled time and place.
This volume is organized into five sections encompassing 30 chapters and begins with an overview of embryonic cells and their two fundamental properties. Cells are not necessarily predetermined and can be experimentally diverted from their normal developmental pathway, and those within an embryonic organism require extrinsic messages to express their developmental capacities. The next chapters focus on early determinative events in embryogenesis, touching on topics such as the genetic aspects of cell type determination, interactions between embryonic cells during the early development of the mouse, and the differentiation of teratocarcinoma stem cells in vitro. The reader is then introduced to positional information and morphogenetic signals; the biological ""specificity"" of morphogenetic tissue interactions; and the molecular mechanisms underlying cell contact interactions. The remaining chapters explore some of the most important conceptual and methodological approaches to the problems of cell-cell recognition and the integration of cells into multicellular systems. This book will be of interest to scientists and investigators in developmental biology and related fields.
List of Participants Preface Opening Remarks Introduction I. Early Determinative Events in Embryogenesis Early Determinative Events in Embryogenesis: An Introduction Analysis of a Cytoplasmic Determinant in a Insect Egg Genetics of Cell Type Determination Interactions between Embryonic Cells during the Early Development of the Mouse The Differentiation of Teratocarcinoma Stem Cells in vitro: Parallels to Normal Embryogenesis II. Positional Information and Morphogenese Signals Positional Information and Morphogenetic Signals: An Introduction Compartments in the Development of Drosophila: A Progress Report Positional Signalling and Nerve Cell Specificity Organizing Principles for Anatomical Patterns and for Selective Nerve Connections in the Developing Amphibian Brain Regulation of Proximo-distal Pattern Formation in the Developing Limb III. Morphogenetic Tissue Interactions Embryonic Induction: An Historical Note Morphogenetic Tissue Interactions: An Introduction Tissue Interactions in Amniote Skin Development The Differentiation of the Ganglioblasts of the Autonomic Nervous System Studied in Chimeric Avian Embryos Tissue Interactions in Tooth Development in vitro Epigenetic Regulation of Enamel Protein Synthesis during Epithelial- Mesenchymal Interactions Studies on Primary Embryonic Induction Kidney Tubule Induction: Physical and Chemical Interference Stimulation of Chondrogenic Differentiation with Extracellular Matrix Components: A n Analysis using Scanning Electron Microscopy IV. Molecular Mechanisms of Cell Contact Interactions Molecular Mechanisms of Cell Contact Interactions: An Introduction Some Biophysical Aspects of Cell Contact, Detachment and Movement Some Chemical Bases for Biological Specificity as Exemplified by Hapten-Antibody Interactions Interactions of Fibronectin, a Cell-Type Specific Surface-Associated
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- © Academic Press 1977
- 1st January 1977
- Academic Press
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