Cell Death Regulation in Health and Disease - Part C

Cell Death Regulation in Health and Disease - Part C

1st Edition - April 30, 2020

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  • Editors: Lorenzo Galluzzi, Johan Spetz
  • Hardcover ISBN: 9780128201350
  • eBook ISBN: 9780128201367

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Cell Death Regulation in Health and Disease - Part C, Volume 353 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists, with this release covering Developmental and seasonal regulation of neural cell death in birds, Post-translational modifications in cell death regulation, The role of cell death in tissue regeneration and fibrosis, Crosstalk between the apoptosis and autophagy signaling pathways, IP3 receptor signal integration in cell death and survival decisions, and more.

Key Features

  • Provides a comprehensive collection of front-of-the line research in the field of cell death regulation
  • Authored by established and active cell and molecular biologists drawn from international sources
  • Includes only invited review articles, covering selected topics in many different organisms and disease settings


Expert investigators who may wish to expand their knowledge of the biology of regulated cell death, and to newcomers to this exciting and rapidly expanding area of research

Table of Contents

  • Preface - Life through death: Key role of cellular suicide for colonial and organismal homeostasis
    Johan K.E. Spetz and Lorenzo Galluzzi
    1. Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases
    Hyejin Park, Tae-In Kam, Ted M. Dawson and Valina L. Dawson
    2. Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases
    Pedro A. Dionísio, Joana D. Amaral and Cecília M.P. Rodrigues
    3. Necroptosis, ADAM proteases and intestinal (dys)function
    Michelle Heib, Stefan Rose-John and Dieter Adam
    4. Regulation of cell death in the cardiovascular system
    Pooja Patel and Jason Karch
    5. The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis
    Gergely Imre
    6. A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate 
    Megan L. Rasmussen and Vivian Gama

Product details

  • No. of pages: 298
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: April 30, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128201350
  • eBook ISBN: 9780128201367

About the Serial Volume Editors

Lorenzo Galluzzi

Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and Expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

Johan Spetz

Johan Spetz (born 1986) is currently a postdoctoral research fellow at the John B. Little Center for Radiation Sciences at Harvard T.H. Chan School of Public Health. With a background as a Medical Physicist (M.Sc. 2010, University of Gothenburg), Johan Spetz’s PhD (2017, University of Gothenburg) focused on peptide receptor radionuclide therapy of small intestine neuroendocrine tumors and biological effects of radiation. This research prompted a further interest in biology, and lead Johan Spetz to enter a postdoctoral research position under the mentorship of Kristopher Sarosiek at Harvard T.H. Chan School of Public Health, with a focus on the regulation of apoptotic priming in response to stress such as irradiation. Specifically, Johan Spetz has worked on measuring dynamic regulation of apoptotic sensitivity in healthy as well as cancerous mammalian cells throughout development and aging, on a single cell level. Through this research, Johan Spetz has identified subsets of cells which are vulnerable to genotoxic stress, within otherwise resistant tissues. Johan Spetz has also worked on the development of functional assays to measure defects in the intrinsic apoptotic pathway, which may be targeted to enhance cancer therapeutics and/or reduce toxic side effects of treatment. Johan Spetz has published 19 articles in peer-reviewed scientific journals and 90+ scientific conference abstracts.

Affiliations and Expertise

Research fellow, John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health

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