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1. Regulation of cell death signaling in insects
2. Bcl-2 family proteins, beyond the veil
3. Cell death signaling in prokaryotes
Robert P. Smith
4. Parthanatos in neurodegenerative diseases
Valina L. Dawson
5. Cell death regulation in yeast
6. Mutual regulation of autophagy and necroptosis
7. Therapeutic inhibition of cell death by autophagy induction
8. Necroptosis in neurodegenerative diseases
The latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists. This release is part of a 3-part series which comprises a comprehensive view of cell death regulation in a variety of biological contexts. The series covers the roles of different cell death mechanisms in various stages of organismal development and disease progression.
- A comprehensive collection of front-of-the line research in the field of cell death regulation
- Authored by established and active cell and molecular biologists and drawn from international sources
- Only invited review articles, covering selected topics in multiple different organisms and disease settings
Expert investigators who may wish to expand their knowledge of the biology of regulated cell death, and to newcomers to this exciting and rapidly expanding area of research
- No. of pages:
- © Academic Press 2020
- 1st May 2020
- Academic Press
- Hardcover ISBN:
Johan Spetz (born 1986) is currently a postdoctoral research fellow at the John B. Little Center for Radiation Sciences at Harvard T.H. Chan School of Public Health. With a background as a Medical Physicist (M.Sc. 2010, University of Gothenburg), Johan Spetz’s PhD (2017, University of Gothenburg) focused on peptide receptor radionuclide therapy of small intestine neuroendocrine tumors and biological effects of radiation. This research prompted a further interest in biology, and lead Johan Spetz to enter a postdoctoral research position under the mentorship of Kristopher Sarosiek at Harvard T.H. Chan School of Public Health, with a focus on the regulation of apoptotic priming in response to stress such as irradiation. Specifically, Johan Spetz has worked on measuring dynamic regulation of apoptotic sensitivity in healthy as well as cancerous mammalian cells throughout development and aging, on a single cell level. Through this research, Johan Spetz has identified subsets of cells which are vulnerable to genotoxic stress, within otherwise resistant tissues. Johan Spetz has also worked on the development of functional assays to measure defects in the intrinsic apoptotic pathway, which may be targeted to enhance cancer therapeutics and/or reduce toxic side effects of treatment. Johan Spetz has published 19 articles in peer-reviewed scientific journals and 90+ scientific conference abstracts.
Research fellow, John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health
Lorenzo Galluzzi (born 1980) is currently Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College (New York, USA), and Honorary Associate Professor at the Faculty of Medicine of the Paris Descartes University (Paris, France). Prior to joining Weill Cornell Medical College (2017), Lorenzo Galluzzi was a Junior Scientist of the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2012-2016). Lorenzo Galluzzi did his post-doctoral training at the Gustave Roussy Cancer Center (Villejuif, France; 2009-2011), after receiving his PhD from the Paris Sud University (Le Kremlin-Bicetre, France; 2005-2008). He is also Associate Director of the European Academy for Tumor Immunology (EATI), and Founding Member of the European Research Institute for Integrated Cellular Pathology (ERI-ICP). Lorenzo Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. In particular, he provided profound insights into the links between adaptive stress responses in cancer cells and the activation of a clinically relevant tumor-targeting immune response in the context of chemotherapy and radiation therapy. Lorenzo Galluzzi has published more than 350 scientific articles in international peer-reviewed journals. According to a survey published by Lab Times, he is currently the 6th and the youngest of the 30 most-cited European cell biologists (relative to the period 2007–2013). Lorenzo Galluzzi currently operates as Editor-in-Chief of three journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, and Molecular and Cellular Oncology (which he co-founded in 2013). In addition, Lorenzo Galluzzi currently serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease.
Weill Cornell Medical College, USA