Cell-Cell Signaling in Vertebrate Development

Cell-Cell Signaling in Vertebrate Development

1st Edition - August 30, 1993

Write a review

  • Editor: E.J. Robertson
  • eBook ISBN: 9780323157759

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Cell-Cell Signaling in Vertebrate Development provides a comprehensive discussion of cell-cell interactions in vertebrate development and the molecular signals that mediate them. The book is divided into six parts, arranged according to major developmental phenomena demonstrated in illustrative systems derived from amphibian, avian, mammalian, and piscine sources. Part I introduces the mechanisms of gene activation in the context of early vertebrate development. Part II is concerned with cellular contacts and the induction process. Cell-cell interactions are illustrated through analyses of neurogenesis in the mouse; embryonic induction is considered in the frog and in the chick. Part III deals with cell migration and differentiation. It examines cell lineages in the frog eyebud; migration phenomena in connection with axon guidance in the embryonic rat spinal cord and mouse visual system; pathfinding by primary motoneurons; and the formation of terminal arbors in zebrafish embryos. Part IV discusses developmental processes that depend on diffusible signals and signal gradients. Part V illustrates pattern formation as exemplified in the developing chick hindbrain and in urodele limb regeneration. Part VI highlights gene expression and its regulation by transcription factors or growth factors in rodent development.

Table of Contents

  • Preface

    Part I Introduction

    1 Mechanisms of Gene Activation in Early Vertebrate Development



    Part II Cell-Cell Contacts and Induction

    2 Control of Granule Cell Neurogenesis and Migration in Developing Cerebellar Cortex


    Granule Cell DNA Synthesis Stimulated by Contacts among Neuronal Precursor Cells

    Influence of Growth Factors on Granule Neuroblast DNA Synthesis

    Duration of Proliferation by Immature Granule Cells in Vitro

    Characterization of the Progeny of Granule Cell Neuroblasts in Vitro

    Initiation of Neuronal Differentiation: The Neurological Mutant Mouse Weaver

    Weaver EGL Cells Fail to Undergo Neuronal Differentiation in Vitro

    Weaver Cells Extend Neurites when Transplanted into Reaggregates of Wild-Type Cells

    Membranes from Wild-Type Cells Rescue the Weaver Defect in Neunte Outgrowth

    Weaver Cells Migrate along Glial Fascicles after Transplantation into Reaggregates of Wild-Type Cells

    Expression of TAG-1 and Astrotactin Increases when Weaver Cells Are Cocultured with Wild-Type Cells

    Features of Migrating Granule Neurons

    Molecular Components of Glia-Guided Neuronal Migration

    Spatiotemporal Pattern of Expression of Astrotactin

    Changing Patterns of Gene Expression Define Four Stages of Granule Neuron Differentiation


    3 Mesoderm Induction and Pattern Formation in the Amphibian Embryo

    Mesoderm Induction and the Establishment of the Basic Body Plan in Xenopus

    Mesoderm Induction and the Formation of the Dorsoventral and Anteroposterior Axes

    Consequences of Mesoderm Induction: The Activation of Regulatory Genes

    The LIM Class of Homeobox Genes in Xenopus Development



    4 Relationships between Mesoderm Induction and Formation of the Embryonic Axis in the Chick Embryo

    Germ Layers and Cell Movement Patterns during Primitive Streak Formation in the Chick Embryo

    Establishment of Cell Diversity: Expression of Cell-Type-Specific Markers during Primitive Streak Formation

    Nature of Macromolecules Carrying the L2/HNK-1 Epitope and Their Possible Involvement in Gastrulation

    Fate of HNK-l-Positive Cells

    Marginal Zone: Organizer of the Early Embryo

    Induction of the Primitive Streak: A Revised View


    Part III Cell Migration and Differentiation

    5 Studies of Neural Cell Lineages Using Injectable Fluorescent Tracers


    Fluorescent Dextran and Retroviral Vectors as Lineage Tracers

    Cell Lineages in the Frog Eyebud

    Cell Lineages in the Spinal Cord and Hindbrain of the Chick

    Concluding Remarks


    6 Axon Guidance in the Mammalian Spinal Cord


    Orientation of Commissural Axons in Response to a Floor Plate-Derived Chemoattractant

    Patterning of Axons by Contact-Mediated Cues at the Floor Plate



    7 Axon Patterning in the Visual System: Divergence of Retinal Axons to Each Side of the Brain at the Midline of the Optic Chiasm

    Dye-Labeling Studies in Fixed Brain: Axon Trajectory and Growth Cone Morphology Reflect the Pattern of Divergence

    Growth Cone Form as an Indicator of Behavior and Cell-Cell Interactions

    Real Time Studies

    Midline of the Optic Chiasm: A First Cue for Divergence

    Fiber-Fiber Interactions Also Contribute to Axon Divergence

    Concluding Remarks


    8 Cellular Interactions Regulating the Formation of Terminal Arbors by Primary Motoneurons in the Zebrafish

    Identified Primary Motoneurons of the Zebrafish

    Pathfinding by the Primary Motoneurons

    Formation of Terminal Arbors

    Extension and Retraction of Projections

    Regulation of Branch Extension and Retraction



    Part IV Gradients and Diffusible Signals

    9 The DVR Gene Family in Embryonic Development


    Results and Discussion


    10 Control of Neural Cell Identity and Pattern by Notochord and Floor Plate Signals


    Induction of the Floor Plate by the Notochord

    Signals from the Floor Plate and Notochord Control Cell Pattern in the Ventral Half of the Neural Tube

    Influence of the Notochord and Floor Plate on Cell Differentiation in the Dorsal Neural Tube

    Possible Mechanisms for the Control of Neural Cell Pattern by the Notochord and Floor Plate


    11 Retinoids and Pattern Formation in Vertebrate Embryos

    Biochemistry of Retinoids

    Retinoids Induce a Homeobox Gene during Early Development of the Chick Embryo

    Retinoic Acid Induces Somite-like Structures in Cranial Mesoderm

    Retinoid Metabolism in Early Chick Embryos


    Part V Pattern Formation

    12 The Relationship between Krox-20 Gene Expression and the Segmentation of the Vertebrate Hindbrain


    Conserved Expression Pattern of Krox-20

    Establishment of Krox-20 Expression in the Neural Epithelium

    Implications for Krox-20 Function

    Relationship between Krox-20 Expression and Lineage Restriction


    13 The Effect of Retinoids on Amphibian Limb Regeneration


    Events of Limb Regeneration

    Effects of Retinoids on Limb Regeneration



    Part VI Transcription Factors

    14 Role of Transcription Factor GATA-1 in the Differentiation of Hemopoietic Cells



    Discussion and Conclusions


    15 Expression of Hox-2 Genes and Their Relationship to Regional Diversity in the Vertebrate Head


    Conservation and Properties of the Hox Network

    Hox Expression in the Branchial Arches: A Hox Code for the Head

    Role of Mesoderm in Neural Plate Regionalization

    Temporal Onset of Expression

    Transmission of Spatial Specification to Other Parts of the Head

    Areas of Reduced Crest Emigration

    Mechanism of Head Segmentation

    Differences in Extent of Specification in Cranial Crest

    Experimental Support for the Hox Code



    16 Murine Paired Box Containing Genes


    Murine Pax Gene Family



    17 Gene Regulation during Nerve Growth Factor-Induced Differentiation

    Expression of Immediate Early Genes

    Expression of Delayed Early Genes

    Expression of Late Genes

    Proto-oncogenes and Neural Development and Function




Product details

  • No. of pages: 284
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: August 30, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9780323157759

About the Editor

E.J. Robertson

Ratings and Reviews

Write a review

There are currently no reviews for "Cell-Cell Signaling in Vertebrate Development"