Cell-Cell Signaling in Vertebrate Development

Cell-Cell Signaling in Vertebrate Development

1st Edition - August 30, 1993

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  • Editor: E.J. Robertson
  • eBook ISBN: 9780323157759

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Description

Cell-Cell Signaling in Vertebrate Development provides a comprehensive discussion of cell-cell interactions in vertebrate development and the molecular signals that mediate them. The book is divided into six parts, arranged according to major developmental phenomena demonstrated in illustrative systems derived from amphibian, avian, mammalian, and piscine sources. Part I introduces the mechanisms of gene activation in the context of early vertebrate development. Part II is concerned with cellular contacts and the induction process. Cell-cell interactions are illustrated through analyses of neurogenesis in the mouse; embryonic induction is considered in the frog and in the chick. Part III deals with cell migration and differentiation. It examines cell lineages in the frog eyebud; migration phenomena in connection with axon guidance in the embryonic rat spinal cord and mouse visual system; pathfinding by primary motoneurons; and the formation of terminal arbors in zebrafish embryos. Part IV discusses developmental processes that depend on diffusible signals and signal gradients. Part V illustrates pattern formation as exemplified in the developing chick hindbrain and in urodele limb regeneration. Part VI highlights gene expression and its regulation by transcription factors or growth factors in rodent development.

Table of Contents


  • Preface

    Part I Introduction

    1 Mechanisms of Gene Activation in Early Vertebrate Development

    Text

    References

    Part II Cell-Cell Contacts and Induction

    2 Control of Granule Cell Neurogenesis and Migration in Developing Cerebellar Cortex

    Introduction

    Granule Cell DNA Synthesis Stimulated by Contacts among Neuronal Precursor Cells

    Influence of Growth Factors on Granule Neuroblast DNA Synthesis

    Duration of Proliferation by Immature Granule Cells in Vitro

    Characterization of the Progeny of Granule Cell Neuroblasts in Vitro

    Initiation of Neuronal Differentiation: The Neurological Mutant Mouse Weaver

    Weaver EGL Cells Fail to Undergo Neuronal Differentiation in Vitro

    Weaver Cells Extend Neurites when Transplanted into Reaggregates of Wild-Type Cells

    Membranes from Wild-Type Cells Rescue the Weaver Defect in Neunte Outgrowth

    Weaver Cells Migrate along Glial Fascicles after Transplantation into Reaggregates of Wild-Type Cells

    Expression of TAG-1 and Astrotactin Increases when Weaver Cells Are Cocultured with Wild-Type Cells

    Features of Migrating Granule Neurons

    Molecular Components of Glia-Guided Neuronal Migration

    Spatiotemporal Pattern of Expression of Astrotactin

    Changing Patterns of Gene Expression Define Four Stages of Granule Neuron Differentiation

    References

    3 Mesoderm Induction and Pattern Formation in the Amphibian Embryo

    Mesoderm Induction and the Establishment of the Basic Body Plan in Xenopus

    Mesoderm Induction and the Formation of the Dorsoventral and Anteroposterior Axes

    Consequences of Mesoderm Induction: The Activation of Regulatory Genes

    The LIM Class of Homeobox Genes in Xenopus Development

    Conclusions

    References

    4 Relationships between Mesoderm Induction and Formation of the Embryonic Axis in the Chick Embryo

    Germ Layers and Cell Movement Patterns during Primitive Streak Formation in the Chick Embryo

    Establishment of Cell Diversity: Expression of Cell-Type-Specific Markers during Primitive Streak Formation

    Nature of Macromolecules Carrying the L2/HNK-1 Epitope and Their Possible Involvement in Gastrulation

    Fate of HNK-l-Positive Cells

    Marginal Zone: Organizer of the Early Embryo

    Induction of the Primitive Streak: A Revised View

    References

    Part III Cell Migration and Differentiation

    5 Studies of Neural Cell Lineages Using Injectable Fluorescent Tracers

    Introduction

    Fluorescent Dextran and Retroviral Vectors as Lineage Tracers

    Cell Lineages in the Frog Eyebud

    Cell Lineages in the Spinal Cord and Hindbrain of the Chick

    Concluding Remarks

    References

    6 Axon Guidance in the Mammalian Spinal Cord

    Introduction

    Orientation of Commissural Axons in Response to a Floor Plate-Derived Chemoattractant

    Patterning of Axons by Contact-Mediated Cues at the Floor Plate

    Summary

    References

    7 Axon Patterning in the Visual System: Divergence of Retinal Axons to Each Side of the Brain at the Midline of the Optic Chiasm

    Dye-Labeling Studies in Fixed Brain: Axon Trajectory and Growth Cone Morphology Reflect the Pattern of Divergence

    Growth Cone Form as an Indicator of Behavior and Cell-Cell Interactions

    Real Time Studies

    Midline of the Optic Chiasm: A First Cue for Divergence

    Fiber-Fiber Interactions Also Contribute to Axon Divergence

    Concluding Remarks

    References

    8 Cellular Interactions Regulating the Formation of Terminal Arbors by Primary Motoneurons in the Zebrafish

    Identified Primary Motoneurons of the Zebrafish

    Pathfinding by the Primary Motoneurons

    Formation of Terminal Arbors

    Extension and Retraction of Projections

    Regulation of Branch Extension and Retraction

    Summary

    References

    Part IV Gradients and Diffusible Signals

    9 The DVR Gene Family in Embryonic Development

    Introduction

    Results and Discussion

    References

    10 Control of Neural Cell Identity and Pattern by Notochord and Floor Plate Signals

    Introduction

    Induction of the Floor Plate by the Notochord

    Signals from the Floor Plate and Notochord Control Cell Pattern in the Ventral Half of the Neural Tube

    Influence of the Notochord and Floor Plate on Cell Differentiation in the Dorsal Neural Tube

    Possible Mechanisms for the Control of Neural Cell Pattern by the Notochord and Floor Plate

    References

    11 Retinoids and Pattern Formation in Vertebrate Embryos

    Biochemistry of Retinoids

    Retinoids Induce a Homeobox Gene during Early Development of the Chick Embryo

    Retinoic Acid Induces Somite-like Structures in Cranial Mesoderm

    Retinoid Metabolism in Early Chick Embryos

    References

    Part V Pattern Formation

    12 The Relationship between Krox-20 Gene Expression and the Segmentation of the Vertebrate Hindbrain

    Introduction

    Conserved Expression Pattern of Krox-20

    Establishment of Krox-20 Expression in the Neural Epithelium

    Implications for Krox-20 Function

    Relationship between Krox-20 Expression and Lineage Restriction

    References

    13 The Effect of Retinoids on Amphibian Limb Regeneration

    Introduction

    Events of Limb Regeneration

    Effects of Retinoids on Limb Regeneration

    Conclusions

    References

    Part VI Transcription Factors

    14 Role of Transcription Factor GATA-1 in the Differentiation of Hemopoietic Cells

    Introduction

    Results

    Discussion and Conclusions

    References

    15 Expression of Hox-2 Genes and Their Relationship to Regional Diversity in the Vertebrate Head

    Introduction

    Conservation and Properties of the Hox Network

    Hox Expression in the Branchial Arches: A Hox Code for the Head

    Role of Mesoderm in Neural Plate Regionalization

    Temporal Onset of Expression

    Transmission of Spatial Specification to Other Parts of the Head

    Areas of Reduced Crest Emigration

    Mechanism of Head Segmentation

    Differences in Extent of Specification in Cranial Crest

    Experimental Support for the Hox Code

    Conclusions

    References

    16 Murine Paired Box Containing Genes

    Introduction

    Murine Pax Gene Family

    Conclusions

    References

    17 Gene Regulation during Nerve Growth Factor-Induced Differentiation

    Expression of Immediate Early Genes

    Expression of Delayed Early Genes

    Expression of Late Genes

    Proto-oncogenes and Neural Development and Function

    Summary

    References

    Index






Product details

  • No. of pages: 284
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: August 30, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9780323157759

About the Editor

E.J. Robertson

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