Cell Biology A Comprehensive Treatise V2

Cell Biology A Comprehensive Treatise V2

The Structure and Replication of Genetic Material

1st Edition - April 28, 1979

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  • Editor: David Prescott
  • eBook ISBN: 9780323147798

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Cell Biology, A Comprehensive Treatise, Volume 2: The Structure and Replication of Genetic Material is mainly about the structure and replication of genetic material in both the nucleus and cytoplasmic organelles. This volume is part of the first four volumes that establish a firm foundation regarding issues of cell structure and function. These issues include cell reproduction, differentiation, and cell-to-cell interactions. This book is divided into nine chapters. Each chapter deals extensively with chromosomes – its physical, genetic, and chemical structures. In addition, this book explains the replication of chromosomes in terms of the cell cycle, as well as their coding capacity. It also discusses the functional organization (structure and levels) of the chromosomes. The concluding chapters present the DNA replication molecular principles and enzymatic machinery. Furthermore, this book explains DNA repair and its relationship to various biological endpoints. The authors of this book reasonably explain and emphasize already established facts and concepts in terms that are relatively easy to understand. Undergraduate and graduate students, teachers, researchers, scientists, and others interested or in need of information regarding cell biology will find this book of great use.

Table of Contents

  • List of Contributors


    Titles of Other Volumes

    1 Chemical, Physical, and Genetic Structure of Prokaryotic Chromosomes

    I. Introduction

    II. Gross Organization of Prokaryotic Chromosomes

    III. Long-Range Organization of DNA in Chromosomes

    IV. Short-Range Structure of DNA in Chromosomes


    2 The Molecular Principles and the Enzymatic Machinery of DNA Replication

    I. Molecular Principles

    II. Molecular Machinery

    Recommended Reading


    3 Replication of the Prokaryotic Chromosome with Emphasis on the Bacterial Chromosome Replication in Relation to the Cell Cycle

    I. Introduction—An Overview of Bacterial Chromosome Replication and Its Regulation in the Context of the Cell Cycle

    II. Initiation

    III. DNA Replication

    IV. Termination of a Round of Replication and Separation of Daughter Molecules

    V. Segregation

    VI. Conclusions


    4 Structure, Coding Capacity, and Replication of Mitochondrial and Chloroplast Chromosomes

    I. Introduction

    II. Identification and Purification of Organelle DNA

    III. Structure and Coding Capacity of Mitochondrial and Chloroplast Chromosomes

    IV. Replication of Mitochondrial and Chloroplast DNA

    V. Concluding Remarks


    5 Mapping the Functional Organization of Eukaryotic Chromosomes

    I. Introduction

    II. Techniques

    III. The Nature of Eukaryotic Genetic Systems


    6 Chromosome Structure and Levels of Chromosome Organization

    I. General Organization of the Eukaryotic Genome

    II. The Organization of DNA in Eukaryotes

    III. The 10-nm Chromatin Fiber

    IV. The 20-nm Chromatin Fiber

    V. Active Chromatin

    VI. Chromomeres

    VII. Mitotic Condensation of Chromosomes

    VIII. Heterochromatin

    IX. Metaphase Chromosome Banding


    7 Strandedness of Chromosomes and Segregation of Replication Products

    I. Introduction

    II. Mitotic Chromosome DNA Duplication

    III. Segregation of Chromosome Subunits

    IV. Segregation of Chromosome Subunits at Meiosis

    V. Sister Chromatid Exchange

    VI. Chromosome Polarity Continuity—A Reminder of Ignorance


    8 Eukaryotic Chromosome Replication and Its Regulation

    I. Organization of the Eukaryotic Chromosome for Replication

    II. Regulation of DNA Replication

    III. Summary


    9 DNA Repair and Its Relationship to Mutagenesis, Carcinogenesis, and Cell Death

    I. Introduction

    II. Biophysical and Biochemical Studies of Repair

    III. Repair Mutants

    IV. Repair and Mutation

    V. Repair and Cell Death

    VI. Carcinogenesis

    VII. Use of Repair to Detect and Measure Damage to DNA

    VIII. Interrelations

    IX. Summary



Product details

  • No. of pages: 506
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: April 28, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9780323147798

About the Editor

David Prescott

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