Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

1st Edition - July 6, 2005

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  • Editors: Edward Bittar, Philippe Frank, Michael Lisanti
  • Hardcover ISBN: 9780444515001
  • eBook ISBN: 9780080458601

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Description

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Readership

Cell biologists, pharmaceutical researchers, and graduate level and medical students

Table of Contents

  • Section 1: Caveolae organization and role in lipid cholesterol metabolism.
    Lipid rafts and caveolae organization.
    Caveolae and the regulation of cellular cholesterol homeostasis.
    Section 2: Caveolae and the regulation of endocytosis.
    The Caveolae Internalization Machinery.
    Lipid raft mediated entry of bacteria into host cells.
    Section 3: Examples of the role of caveolins in cell signaling.
    The caveolin interaction with the endothelial nitric oxide synthase (eNOS).
    Caveolae and Estrogen Receptor Signaling.
    eNOS regulation by sphingosine 1-phosphate and caveolin.
    Insulin signaling and caveolae.
    Section 4: Caveolae and pathologies.
    Caveolin-3, Caveolae, and Hereditary Muscle Diseases.
    Caveolae and Caveolins in the Vascular System.
    Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Elsevier Science 2005
  • Published: July 6, 2005
  • Imprint: Elsevier Science
  • Hardcover ISBN: 9780444515001
  • eBook ISBN: 9780080458601

About the Editors

Edward Bittar

Affiliations and Expertise

Department of Physiology, University of Wisconsin Medical School, Madison, USA

Philippe Frank

Michael Lisanti

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