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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease - 1st Edition - ISBN: 9780444515001, 9780080458601

Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease, Volume 36

1st Edition

Editor: Edward Bittar
Hardcover ISBN: 9780444515001
eBook ISBN: 9780080458601
Imprint: Elsevier Science
Published Date: 6th July 2005
Page Count: 264
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Table of Contents

Section 1: Caveolae organization and role in lipid cholesterol metabolism. Lipid rafts and caveolae organization. Caveolae and the regulation of cellular cholesterol homeostasis. Section 2: Caveolae and the regulation of endocytosis. The Caveolae Internalization Machinery. Lipid raft mediated entry of bacteria into host cells. Section 3: Examples of the role of caveolins in cell signaling. The caveolin interaction with the endothelial nitric oxide synthase (eNOS). Caveolae and Estrogen Receptor Signaling. eNOS regulation by sphingosine 1-phosphate and caveolin. Insulin signaling and caveolae. Section 4: Caveolae and pathologies. Caveolin-3, Caveolae, and Hereditary Muscle Diseases. Caveolae and Caveolins in the Vascular System. Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.


Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.


Cell biologists, pharmaceutical researchers, and graduate level and medical students


No. of pages:
© Elsevier Science 2005
6th July 2005
Elsevier Science
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Editor

Edward Bittar

Affiliations and Expertise

Department of Physiology, University of Wisconsin Medical School, Madison, USA