Catalytic RNA, Volume 120

1st Edition

Serial Volume Editors: Garrett A. Soukup
Hardcover ISBN: 9780123812865
eBook ISBN: 9780123812872
Imprint: Academic Press
Published Date: 5th November 2013
Page Count: 248
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Table of Contents

Contributors

Preface

Chapter One. The Hammerhead Ribozyme: Structure, Catalysis, and Gene Regulation

Abstract

1 Discovery and Context

2 The Minimal Sequence

3 The Full-Length Sequence

4 Hammerhead Ribozymes in Mammalian Gene Regulation

References

Chapter Two. Bridging the Gap Between Theory and Experiment to Derive a Detailed Understanding of Hammerhead Ribozyme Catalysis

Abstract

1 Introduction

2 A Metal Ion Story with a Happy Ending

3 Finding the Catalytic Reaction Path Through Multidimensional Free-Energy Surfaces

4 HHR Uses Specific Cation-Binding Modes to Reach Its Catalytically Active Conformation

5 Computational Mutagenesis of Key Residues of HHR

6 Conclusion

Acknowledgments

References

Chapter Three. A Mechanistic Comparison of the Varkud Satellite and Hairpin Ribozymes

Abstract

1 Introduction

2 The Hairpin and VS Ribozymes

3 General Themes

Acknowledgments

References

Chapter Four. HDV Family of Self-Cleaving Ribozymes

Abstract

1 Introduction

2 Hepatitis Delta Virus

3 HDV Ribozymes

4 HDV Ribozymes’ Reaction Mechanism

5 Ribozymes Outside of the Hepatitis Delta Virus

6 Evolutionary Relationship Among HDV-Like Ribozymes

References

Chapter Five. The Structural and Functional Uniqueness of the glmS Ribozyme

Abstract

1 Introduction

2 The glmS Riboswitch/Ribozyme

3 Biological Function of the glmS Ribozyme

4 glmS Ribozyme Uniqueness

5 glmS Ribozyme Structure and Function—Biochemical Analyses

6 glmS Ribozyme Structure and Function—Crystallographic Analysis

7 Metal Ion Usage by the glmS Ribozyme

8 Essential Coenzyme GlcN6P Functional Groups


Description

This special volume of Progress in Molecular Biology and Translational Science focuses on catalytic RNA. Written by experts in the field, the reviews cover a range of topics, from hammerhead ribozymes to spliceosome catalysis to Varkud satellite and hairpin ribozymes.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


Details

No. of pages:
248
Language:
English
Copyright:
© Academic Press 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780123812872
Hardcover ISBN:
9780123812865

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal


About the Serial Volume Editors

Garrett A. Soukup Serial Volume Editor

Affiliations and Expertise

Creighton University, Omaha, USA