Catalytic RNA - 1st Edition - ISBN: 9780123812865, 9780123812872

Catalytic RNA, Volume 120

1st Edition

Serial Volume Editors: Garrett A. Soukup
eBook ISBN: 9780123812872
Hardcover ISBN: 9780123812865
Imprint: Academic Press
Published Date: 5th November 2013
Page Count: 248
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
118.00
82.60
82.60
82.60
82.60
82.60
94.40
94.40
156.00
109.20
109.20
109.20
109.20
109.20
124.80
124.80
95.00
66.50
66.50
66.50
66.50
66.50
76.00
76.00
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Contributors

Preface

Chapter One. The Hammerhead Ribozyme: Structure, Catalysis, and Gene Regulation

Abstract

1 Discovery and Context

2 The Minimal Sequence

3 The Full-Length Sequence

4 Hammerhead Ribozymes in Mammalian Gene Regulation

References

Chapter Two. Bridging the Gap Between Theory and Experiment to Derive a Detailed Understanding of Hammerhead Ribozyme Catalysis

Abstract

1 Introduction

2 A Metal Ion Story with a Happy Ending

3 Finding the Catalytic Reaction Path Through Multidimensional Free-Energy Surfaces

4 HHR Uses Specific Cation-Binding Modes to Reach Its Catalytically Active Conformation

5 Computational Mutagenesis of Key Residues of HHR

6 Conclusion

Acknowledgments

References

Chapter Three. A Mechanistic Comparison of the Varkud Satellite and Hairpin Ribozymes

Abstract

1 Introduction

2 The Hairpin and VS Ribozymes

3 General Themes

Acknowledgments

References

Chapter Four. HDV Family of Self-Cleaving Ribozymes

Abstract

1 Introduction

2 Hepatitis Delta Virus

3 HDV Ribozymes

4 HDV Ribozymes’ Reaction Mechanism

5 Ribozymes Outside of the Hepatitis Delta Virus

6 Evolutionary Relationship Among HDV-Like Ribozymes

References

Chapter Five. The Structural and Functional Uniqueness of the glmS Ribozyme

Abstract

1 Introduction

2 The glmS Riboswitch/Ribozyme

3 Biological Function of the glmS Ribozyme

4 glmS Ribozyme Uniqueness

5 glmS Ribozyme Structure and Function—Biochemical Analyses

6 glmS Ribozyme Structure and Function—Crystallographic Analysis

7 Metal Ion Usage by the glmS Ribozyme

8 Essential Coenzyme GlcN6P Functional Groups

9 Mechanism of glmS Ribozyme Self-Cleavage Using Coenzyme GlcN6P

10 pH-Reactivity Profiles Provide Mechanistic Insight

11 Potential for Antibiotic Development Affecting glmS Ribozyme/Riboswitch Function

Acknowledgments

References

Chapter Six. The Role of snRNAs in Spliceosomal Catalysis

Abstract

1 Evolution of Eukaryotic Splicing Machines

2 Structural and Functional Similarities Between snRNAs and the Group II Self-Splicing Introns

3 Role of snRNAs in the Spliceosomal Active Site

4 The Three-Dimensional Positioning of snRNAs in the Catalytic Core

5 An RNA-Centric View of the Active Site

6 Functionally Critical snRNA–Metal Ion Interactions

7 Catalytic Activity of the snRNAs in Isolation

8 The snRNAs in the Context of the Spliceosomal Active Site

9 The Role of Proteins in the Spliceosomal Catalytic Core

10 The Role of Spliceosomal Proteins in Remodeling the Catalytic Core

11 Concluding Remarks

References

Index


Description

This special volume of Progress in Molecular Biology and Translational Science focuses on catalytic RNA. Written by experts in the field, the reviews cover a range of topics, from hammerhead ribozymes to spliceosome catalysis to Varkud satellite and hairpin ribozymes.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


Details

No. of pages:
248
Language:
English
Copyright:
© Academic Press 2013
Published:
Imprint:
Academic Press
eBook ISBN:
9780123812872
Hardcover ISBN:
9780123812865

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal


About the Serial Volume Editors

Garrett A. Soukup Serial Volume Editor

Affiliations and Expertise

Creighton University, Omaha, USA