Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine

1st Edition - November 28, 2023
Editors: J. Miguel Oliveira, Rui L. Reis, Sandra Pina
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 8 2 1 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 7 2 6 2 - 8

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and… Read more

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Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.

Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1. Fundamentals and mechanisms
1. Introduction
2. Cell types used in skeletal muscle bioengineered models
3. Biomaterials for skeletal muscle engineering
4. Topographical and mechanical cues for skeletal muscle formation
5. Concluding remarks
Chapter 2. Stimuli-responsive biomaterials for regulation of dynamic cellular responses toward advanced tissue engineering
1. Introduction
2. Stimuli-responsive materials
3. Dynamic material response by stimulation
4. Conclusion and perspectives
Chapter 3. Closer to nature: Recreating extracellular matrix microenvironment with 3D printing
1. Introduction
2. ECM role and composition
3. Biomaterials for three-dimensional printing of ECM analog
4. Conclusions and future perspectives
Chapter 4. Surface modification and its influence on osseointegration of implants
1. Introduction
2. Calcium phosphate
3. Clinical relevance of mechanical stability of micro- and nanocoatings
4. Surface modification via nanocoatings and nanocomposite coatings
5. Infection prevention via gentamicin–calcium phosphate coatings
6. Concluding remarks
Chapter 5. Mechanical performance of metallic biomaterials: Fundamentals and mechanisms
1. Introduction
2. Structure of metals
3. Conclusions and future prospects
Chapter 6. Mechanobiology regulation
1. Introduction: mechanobiology, musculoskeletal tissue development, and regeneration
2. Mechanobiological regulation of tissue differentiation
3. Tissue regeneration strategies leveraging mechanobiology regulation
4. Computational modeling approaches to study mechanobiology regulation
5. Conclusions and future perspectives
Chapter 7. Electrical/magnetic stimulation in musculoskeletal tissue engineering and regenerative medicine
1. Introduction
2. Electroconductive and magnetic biomaterials
3. Conclusion
Chapter 8. Cell–biomaterials interactions: Mechanical forces assessment by traction force microscopy
1. Introduction
2. Methods for measuring mechanical forces in cell biology
3. Traction force microscopy
4. Traction force microscopy for musculoskeletal tissue engineering
5. Protocol summary
6. Discussion
7. Conclusions
Chapter 9. Mineralogical characterization of calcium phosphate cements for clinical needs
1. Development of calcium phosphate cements
2. Mineralogical and physicochemical basics
3. Application-relevant properties of calcium phosphate cements
4. Advanced X-ray diffraction methods for quantitative phase analysis of CPCs and their hydration
5. G-factor—the method for absolute phase quantification
6. Methods for characterization of calcium phosphate cement setting reactions and kinetics of hydration
7. Concluding remarks
Chapter 10. Design of polymeric biomaterials at multiscale
1. Introduction
2. Polymer selection
3. Micro- and nanoscale design
4. Macroscale design
5. Concluding remarks
Chapter 11. Immunomodulatory hydrogels: Design and applications
1. Introduction
2. Strategies for the design of immunomodulatory hydrogels
3. Biomedical application of immunomodulatory hydrogels
4. Conclusions
Chapter 12. Scaffolding design and structure/function: Focus on electrospinning for tendon engineering
1. Introduction
2. Principles of electrospinning
3. Molecular electrospinning
4. Cellular electrospinning
5. Conclusions
Chapter 13. Scaffolding design and structure/function: Advanced manufacturing
1. Introduction
2. Intended application of the tissue-engineered scaffolds: Structure/function properties
3. Advanced manufacturing technologies for scaffold fabrication
4. Hierarchical design of scaffolds by additive manufacturing
5. Conclusions
Chapter 14. Bioprinting strategy toward realization of structural and functional tissue engineering scaffolds
1. Introduction
2. Bioprinting for repair and regeneration of musculoskeletal tissue
3. Structural requirement for the musculoskeletal tissue engineering scaffolds
4. Strategies for realization of functional scaffolds
5. Conclusion and perspective remarks
Chapter 15. Dynamic models for investigating structure/function of biomaterials: bioreactors
1. Introduction
2. Physics of musculoskeletal system bioreactors
3. Bioreactors in musculoskeletal tissue engineering
4. Other working parameters for musculoskeletal tissue engineering bioreactors
5. Conclusions and perspectives
Chapter 16. Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling
1. Introduction
2. Biomaterials properties as aECM for 3D in vitro modeling
3. Silk fibroin features and suitability as aECM for 3D in vitro modeling
4. Conclusions and future directions
Chapter 17. In vivo animal models
1. Introduction
2. Animal models in muscle tissue engineering
3. Animal models in ligaments and tendons tissue engineering
4. Animal models in bone tissue engineering
5. Animal models in cartilage tissue engineering
6. Conclusions
Chapter 18. Regulatory and clinical translation
1. Introduction
2. Translational concerns
3. Preclinical stages
4. Translational stage
5. Production stage
6. ATMP approval for clinical trials
7. Costs
8. Clinical trials
9. Regulatory issues
10. Concluding remarks and future trends
Chapter 19. Cells–biomaterials structure–function at different length scales
1. Introduction
2. Macroscale to nanoscale approaches for musculoskeletal tissue engineering
3. Different approaches for musculoskeletal tissue engineering
4. Scaffolds for skeletal muscle tissue engineering
5. Skeletal muscle progenitor cells for tissue engineering
6. Biomaterials for skeletal muscle tissue engineering
7. Conclusions and future perspective
Index

J. Miguel Oliveira

J. Miguel Oliveira, BSc, PhD is the Director of Pre-Clinical Research at the FIFA MEDICAL CENTER, Estádio do Dragão, Porto, PT since Fev. 2013. Currently, he is a Lecturer in Doctoral Programme in Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho, PT. He is also an Invited lecturer at the Faculty of Medicine, U. Porto (since Sept. 2013) and Dept. of Polymer Eng., UM, PT. Dr. Oliveira has published over 220 scientific contributions in scientific journals. Miguel Oliveira was approved 17 patents, published 5 books, 3 special issue in scientific journals, and more than 90 book chapters in books with international circulation. In addition, he is member of the advisory board of the Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, The Journal of Experimental Orthopaedics, Journal “Recent Patents on Corrosion Science”, and referee in more than 40 international journals.

Affiliations and expertise

Principal Investigator with Habilitation and Vice President of Institute 3B's, 3B’s Research Group, Institute 3B’s, University of Minho, Braga, Portugal

Rui L. Reis

Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.

Affiliations and expertise

President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal

Sandra Pina

Sandra Pina is Assistant Researcher at 3B’s Research Group, Institute 3B’s, University of Minho, Barco, Portugal.

Affiliations and expertise

Assistant Researcher, 3B’s Research Group, Institute 3B’s, University of Minho, Barco, Portugal