Carnitine Biosynthesis Metabolism, And Functions

Carnitine Biosynthesis Metabolism, And Functions

1st Edition - January 1, 1980

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  • Editor: Rene Frenkel
  • eBook ISBN: 9780323153409

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Carnitine Biosynthesis, Metabolism, and Functions contains the proceedings of the Virginia Lazenby O'Hara Biochemistry Symposium held in Dallas, Texas, from March 31 to April 1, 1979. The papers explore all aspects of carnitine metabolism, including its biosynthesis, regulation, transport, and functions. Comprised of 24 chapters divided into four sections, this book opens with a brief review of the situation which led to the discovery of carnitine as a vitamin and its role in acetylation. The discussion then turns to the chemistry and biosynthesis of carnitine in Neurospora crassa, rat kidney, and humans. The purification of enzymes involved in the conversion of trimethyllysine to trimethylaminobutyrate is also considered. The following chapters examine carnitine transport across the plasma membrane; formation and utilization of isobutyrylcarnitine; regulation of blood carnitine and carnitine acyltransferases in the perinatal period; and inhibitors of carnitine transport and metabolism. The final section is devoted to medical and clinical aspects of carnitine, touching on topics such as the possible causes and effects of carnitine deficiency in humans; carnitine deficiency in cirrhosis; protective effects of L-carnitine on ischemic heart; and changes in carnitine-linked metabolism during ischemia, thermal injury, and shock. This monograph will be a useful resource for biochemists and those interested in the physiological roles of carnitine.

Table of Contents

  • Participants




    Opening Lecture: The Proposed Vitamin Role of Carnitine

    Section I: Chemistry and Biosynthesis

    Carnitine Biosynthesis in Neurospora crassa

    Synthesis of Carnitine Precursors in Rat Kidney

    Purification of the Enzymes Involved in the Conversion of Trimethyllysine to Trimethylaminobutyrate

    Hydroxylation of γ-Butyrobetaine

    Comparative Aspects of Carnitine Biosynthesis in Microorganisms and Mammals with Attention to Carnitine Biosynthesis in Man

    Section II: Regulation and Functions I

    Carnitine Transport across the Plasma Membrane

    Carnitine Uptake and Stimulation of Carnitine Uptake in the Isolated Beating Adult Rat Heart Myocyte

    Regulation of the Carnitine Concentration in Plasma

    Extramitochondrial Shortening of Long Chain Fatty Acids and Carnitine-Dependent Fatty Acid Oxidation

    Carnitine-Acylcarnitine Translocase-Mediated Transport of Fatty Acids into Mitochondria: Its Involvement in the Control of Fatty Acid Oxidation in Liver

    Studies on the Formation and Utilization of Isobutyrylcarnitine

    Section III: Regulation and Functions II

    Control of Blood Carnitine and Carnitine Acyltransferases in the Perinatal Period

    Carnitine and Metabolism in Ruminant Animals

    Inhibitors of Carnitine Transport and Metabolism

    Carnitine in the Male Reproductive Tract and Its Relation to the Metabolism of the Epididymis and Spermatozoa

    Concentration and Uptake of Carnitine in the Rat Epididymis: A Micropuncture Study

    The Role of Carnitine and Its Esters in Sperm Metabolism

    Section IV: Medical and Clinical Aspects

    Possible Causes and Effects of Carnitine Deficiency in Man

    Carnitine and Carnitine Palmitoyltransferase in Metabolic Studies

    Carnitine Deficiency in Cirrhosis

    Changes in Carnitine-Linked Metabolism during Ischemia, Thermal Injury, and Shock

    Protective Effects of L-Carnitine on Ischemic Heart


Product details

  • No. of pages: 376
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323153409

About the Editor

Rene Frenkel

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