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Carnitine Biosynthesis, Metabolism, and Functions contains the proceedings of the Virginia Lazenby O'Hara Biochemistry Symposium held in Dallas, Texas, from March 31 to April 1, 1979. The papers explore all aspects of carnitine metabolism, including its biosynthesis, regulation, transport, and functions.
Comprised of 24 chapters divided into four sections, this book opens with a brief review of the situation which led to the discovery of carnitine as a vitamin and its role in acetylation. The discussion then turns to the chemistry and biosynthesis of carnitine in Neurospora crassa, rat kidney, and humans. The purification of enzymes involved in the conversion of trimethyllysine to trimethylaminobutyrate is also considered. The following chapters examine carnitine transport across the plasma membrane; formation and utilization of isobutyrylcarnitine; regulation of blood carnitine and carnitine acyltransferases in the perinatal period; and inhibitors of carnitine transport and metabolism. The final section is devoted to medical and clinical aspects of carnitine, touching on topics such as the possible causes and effects of carnitine deficiency in humans; carnitine deficiency in cirrhosis; protective effects of L-carnitine on ischemic heart; and changes in carnitine-linked metabolism during ischemia, thermal injury, and shock. This monograph will be a useful resource for biochemists and those interested in the physiological roles of carnitine.
Opening Lecture: The Proposed Vitamin Role of Carnitine
Section I: Chemistry and Biosynthesis
Carnitine Biosynthesis in Neurospora crassa
Synthesis of Carnitine Precursors in Rat Kidney
Purification of the Enzymes Involved in the Conversion of Trimethyllysine to Trimethylaminobutyrate
Hydroxylation of γ-Butyrobetaine
Comparative Aspects of Carnitine Biosynthesis in Microorganisms and Mammals with Attention to Carnitine Biosynthesis in Man
Section II: Regulation and Functions I
Carnitine Transport across the Plasma Membrane
Carnitine Uptake and Stimulation of Carnitine Uptake in the Isolated Beating Adult Rat Heart Myocyte
Regulation of the Carnitine Concentration in Plasma
Extramitochondrial Shortening of Long Chain Fatty Acids and Carnitine-Dependent Fatty Acid Oxidation
Carnitine-Acylcarnitine Translocase-Mediated Transport of Fatty Acids into Mitochondria: Its Involvement in the Control of Fatty Acid Oxidation in Liver
Studies on the Formation and Utilization of Isobutyrylcarnitine
Section III: Regulation and Functions II
Control of Blood Carnitine and Carnitine Acyltransferases in the Perinatal Period
Carnitine and Metabolism in Ruminant Animals
Inhibitors of Carnitine Transport and Metabolism
Carnitine in the Male Reproductive Tract and Its Relation to the Metabolism of the Epididymis and Spermatozoa
Concentration and Uptake of Carnitine in the Rat Epididymis: A Micropuncture Study
The Role of Carnitine and Its Esters in Sperm Metabolism
Section IV: Medical and Clinical Aspects
Possible Causes and Effects of Carnitine Deficiency in Man
Carnitine and Carnitine Palmitoyltransferase in Metabolic Studies
Carnitine Deficiency in Cirrhosis
Changes in Carnitine-Linked Metabolism during Ischemia, Thermal Injury, and Shock
Protective Effects of L-Carnitine on Ischemic Heart
- No. of pages:
- © Academic Press 1980
- 1st January 1980
- Academic Press
- eBook ISBN:
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