Cardiovascular Pathology

Cardiovascular Pathology

5th Edition - January 22, 2022

Write a review

  • Editors: L. Maximilian Buja, Jagdish Butany
  • Hardcover ISBN: 9780128222249
  • eBook ISBN: 9780323912587

Purchase options

Purchase options
In Stock
DRM-free (EPub, PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

Key Features

  • Includes expanded coverage of diagnostic guidelines, standards and normal values
  • Provides a summary of cardiac catheterization laboratory and diagnostic imaging tests to guide pathologists in clinicopathological correlation
  • Presents a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows in pathology, cardiology, cardiac surgery, and internal medicine
  • Provides comprehensive coverage, including, when appropriate, Central Concept Figure, Definition, Epidemiology, Clinical Presentation, Pathogenesis, Molecular Genetics, Light and Electron Microscopy, Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications, and a Bulleted Summary

Readership

Practicing pathologists, pathology residents, biomedical researchers

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of contributors
  • About the editors
  • Preface
  • Acknowledgments
  • Chapter 1. Cardiovascular pathology: guide to practice and training
  • Abstract
  • Introduction
  • Autopsy
  • Genetics and molecular biology
  • Surgical pathology
  • Endomyocardial biopsy
  • Heart transplant pathology
  • Cardiovascular clinical diagnostic and imaging studies
  • Training in cardiovascular pathology
  • Cardiovascular pathologist roles as diagnostician, teacher, consultant, and care team member
  • Summary
  • References
  • Chapter 2. Anatomic considerations and examination of cardiovascular specimens (excluding devices)
  • Abstract
  • Gross examination of the heart
  • Examination of surgical cardiovascular specimens
  • Microscopic examination of the blood vessels and heart
  • Genetics
  • Summary
  • References
  • Chapter 3. Age-related cardiovascular changes and diseases
  • Abstract
  • Introduction
  • Nonspecific cardiovascular changes of aging
  • Changes in the conduction system
  • Changes in arteries
  • Age-related diseases
  • Genetic and molecular aspects of cardiovascular aging
  • Summary
  • References
  • Chapter 4. Fundamental principles in cardiovascular genetics
  • Abstract
  • Central concept figure
  • Notable abbreviations
  • Genetic variation
  • Modern molecular diagnostics
  • Identifying the genetic basis of cardiovascular disease
  • Molecular diagnostics in cardiovascular pathology practice
  • Summary
  • References
  • Chapter 5. Pathophysiology of heart failure and an overview of therapies
  • Abstract
  • Overview of heart failure
  • Clinical presentation and diagnostic criteria
  • Pathophysiology of heart failure
  • Neurohormonal alterations in heart failure
  • Myocardial architecture
  • Molecular responses and adaptation of cardiac cells
  • Metabolic remodeling in heart failure
  • Short- to intermediate-term circulatory support devices
  • Conclusion
  • Summary
  • References
  • Chapter 6. Congenital heart disease: pathology, natural history, and interventions
  • Abstract
  • Abbreviations
  • Introduction
  • Definition
  • Epidemiology
  • Etiology
  • Embryology of the cardiovascular system
  • Clinical features and consequences
  • Specific forms of congenital heart disease
  • Surgical and nonsurgical interventions
  • Congenital heart disease in the adult
  • Natural history without and with interventions
  • Summary
  • References
  • Chapter 7. Vascular Pathobiology: Atherosclerosis and Large Vessel Disease
  • Abstract
  • Introduction to atherosclerosis
  • Epidemiology and risk factors
  • Gross and microscopic morphology of the fibroinflammatory lipid plaque
  • Steps in atherosclerotic plaque formation and complications
  • Cellular function and pathways in atherogenesis
  • Nonatherosclerotic diseases of the aorta
  • Summary
  • References
  • Chapter 8. Diseases of small and medium-sized blood vessels
  • Abstract
  • Introduction
  • Vascular activation and common vascular pathologic changes
  • Congenital vascular diseases
  • Genetic vascular disorders
  • Endocrine/metabolic vascular disorders
  • Vasculitis
  • Infection
  • Toxic vasculopathies
  • Coagulopathic disorders
  • Hypertension
  • Vascular deposition disorders
  • Intimal proliferative diseases
  • Arterial dissections
  • Miscellaneous conditions
  • Disorders of veins
  • Summary
  • References
  • Chapter 9. Aneurysms of the aorta: ascending, thoracic, and abdominal and their management
  • Abstract
  • Introduction
  • Normal anatomy and histology of the aorta
  • Aging changes of the aorta
  • Thoracic aortic aneurysms
  • Etiology and pathologic findings
  • Clinical presentation and natural history
  • Abdominal aortic aneurysm
  • Aortic dissection
  • Management
  • Summary
  • References
  • Chapter 10. Myocardial ischemia and its complications
  • Abstract
  • Definition and history
  • Universal definition of myocardial infarction
  • Clinical manifestations
  • Epidemiology
  • Biochemical changes with ischemia and biochemical markers
  • Ultrastructural evolution of acute ischemic injury
  • Cellular and subcellular mechanisms of myocardial injury
  • Microscopic evolution of acute ischemic injury
  • Morphology of coronary arteries and plaques
  • Tako–Tsubo cardiomyopathy
  • Gross evolution of acute ischemic injury
  • Patterns of myocardial infarction
  • Phenomena associated with ischemic injury
  • Reperfusion of ischemic myocardium
  • Complications of myocardial infarction
  • Recognition and quantification of acute ischemic injury
  • Pathology of interventions
  • Pathophysiological and pharmacological interventions
  • Genetics and molecular biology of ischemic heart disease
  • Genetics of coronary artery disease
  • Molecular biology of coronary artery disease
  • Cell-based therapies for ischemic heart disease
  • Summary
  • References
  • Chapter 11. Pathology of sudden death, cardiac arrhythmias, and conduction system
  • Abstract
  • Sudden death
  • Cardiac conduction system
  • Atrial fibrillation
  • Appendix guidelines for postmortem study of sudden death
  • Acknowledgments
  • Summary
  • References
  • Chapter 12. Toxins and the heart
  • Abstract
  • Introduction
  • Endocardium
  • Myocardium
  • Pericardium
  • Coronary arteries and ischemia
  • Conduction system
  • Specific drug considerations
  • Environmental pollutants
  • Myocardial toxins as a cause of death
  • Genetics and molecular biology
  • Summary
  • References
  • Chapter 13. Myocarditis
  • Abstract
  • Abbreviations
  • Definition of myocarditis
  • Diagnosis of myocarditis
  • Histopathologic patterns of myocarditis
  • Etiologies of myocarditis
  • Treatment of myocarditis
  • Molecular and genetic technologies and considerations in myocarditis
  • Summary
  • References
  • Chapter 14. Cardiomyopathies
  • Abstract
  • Definition and classification of cardiomyopathies
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Arrhythmogenic cardiomyopathy
  • Restrictive cardiomyopathy
  • Others
  • Genetics and molecular biology
  • Summary
  • References
  • Chapter 15. The pericardium and its diseases
  • Abstract
  • Normal pericardium
  • Patterns of pathology
  • Diagnostic techniques
  • Major diagnoses
  • Molecular considerations
  • Summary
  • References
  • Chapter 16. Valvular heart disease
  • Abstract
  • Introduction
  • Normal valvular function
  • Valvular dysfunction
  • Aortic stenosis
  • Mitral stenosis
  • Nonrheumatic mitral stenosis
  • Rheumatic mitral regurgitation
  • Other causes of mitral regurgitation
  • Tricuspid valvular dysfunction
  • Pulmonary valvular dysfunction
  • Verrucous endocarditis
  • Summary
  • References
  • Chapter 17. Cardiac valve replacement and related interventions
  • Abstract
  • General considerations
  • Valve-related complications: clinical importance, morphology, secondary effects, and pathogenesis
  • Other tissue valve substitutes
  • Transcatheter valve implantation
  • Valve repair and valve sparing procedures
  • New developments and future considerations
  • Pathologic considerations in analysis of heart valve substitutes
  • Disclosure
  • Appendix. Some Heart valve prostheses approved by the FDA
  • Summary
  • References
  • Chapter 18. The pathology of cardiovascular interventions and devices for coronary artery disease, vascular disease, heart failure, and arrhythmias
  • Abstract
  • Central concept figure: comprehensive medical device pathology
  • Introduction
  • Endovascular therapies and myocardial revascularization
  • Aortic and peripheral vascular replacement and reconstruction
  • Cardiac assist and replacement
  • Arrhythmia control
  • Summary
  • References
  • Chapter 19. Tumors of the cardiovascular system: heart and blood vessels
  • Abstract
  • Incidence and classification
  • Clinical symptoms
  • Reactive cardiac masses and pseudotumors
  • Ectopias
  • Hamartomas and benign neoplasms
  • Hamartomas of the cardiac muscle
  • Benign fatty tumors
  • Benign tumors of the myofibroblastic tissue
  • Miscellaneous benign fibrous tumors
  • Cardiac myxoma
  • Benign neural neoplasms
  • Primary neoplasms and genetics
  • Metastatic tumors
  • Sarcomas of the great vessels
  • Summary
  • References
  • Chapter 20. Pathology of cardiac transplantation
  • Abstract
  • General clinicopathologic considerations
  • Pathology of the explanted recipient heart
  • Pathology of the donor heart
  • Pathology of the allograft
  • Posttransplant lymphoproliferative disorders
  • Causes of death in heart transplant recipients
  • Heart transplantation in combination with other organs
  • Pathological review of an endomyocardial biopsy
  • Approach to the examination of a failed allograft
  • Noninvasive molecular testing for cardiac allograft rejection
  • Future considerations
  • Summary
  • References
  • Chapter 21. Basic pathobiology of cell-based therapies and cardiac regenerative medicine
  • Abstract
  • Central concept figure: evolution of cell therapy for myocardial repair and regeneration
  • Introduction
  • The rise (and fall) of the myocardial regeneration hypothesis
  • Classic descriptions of growth, hypertrophy and failure of the heart
  • Contemporary overview of cardiomyocytes biology
  • Contemporary perspectives on myocardial pathobiology
  • Experimental studies of stem cell therapy
  • Clinical studies and trials of stem cell therapy
  • Challenges to the rationale for cardiac stem cell therapy
  • Regulatory considerations
  • Alternatives to exogenous stem cell therapy
  • Perspectives
  • Summary
  • References
  • Chapter 22. Forensic aspects of cardiovascular pathology
  • Abstract
  • Investigative information
  • General changes
  • Cardiovascular pathology consultation
  • Injuries of the heart and major vessels
  • Primary diseases of the heart
  • Infectious and inflammatory conditions affecting the heart
  • Diseases of the cardiac valves
  • Anomalies and diseases of the aorta and coronary arteries
  • Systemic diseases affecting the heart and major vessels
  • Ancillary studies
  • Sudden death following surgical and medical procedures
  • Organ and tissue procurement
  • Summary
  • References
  • Index

Product details

  • No. of pages: 994
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 22, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128222249
  • eBook ISBN: 9780323912587

About the Editors

L. Maximilian Buja

L. Maximilian Buja
Professor of Pathology and Laboratory Medicine, Medical School, The University of Texas Health Science Center at Houston (UTHealth); Distinguished Teaching Professor, The University of Texas System; Executive Director, The TMC Library; Editor-in-Chief, Cardiovascular Pathology (the official journal of the Society for Cardiovscular Pathology) Dr. Buja MD is a Professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center at Houston. His subspecialty interest is cardiovascular pathology with research interests in myocardial cell injury, myocardial ischemia, atherosclerosis and cardiomyopathies. Dr. Buja teaches medical students, medical residents, clinical fellows, graduate students and research post-doctoral fellows. He also conducts a clinical practice in cardiovascular pathology providing staffing of autopsy cases and surgical pathology consultation of cardiac and vascular cases and interpretation of myocardial biopsies from referrals. He directs a cardiovascular pathology fellowship approved by the Texas Medical Board. He is the editor-in-chief of Cardiovascular Pathology, the official journal of the Society for Cardiovascular Pathology. He also serves as the Executive Director of The Texas Medical Center Library located adjacent to the medical school.

Affiliations and Expertise

Professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center, Houston, TX, USA

Jagdish Butany

Consultant Cardiovascular Pathologist/Director Autopsy Services Co-Editor-in-Chief, Cardiovascular Pathology, Guest Editor, Seminars in Diagnostic Pathology Secretary-Treasurer, WASPaLM, Professor, University of Toronto & Director, Division of Pathology,Dept. of Laboratory Medicine and Pathobiology, University Health Network / Laboratory Medicine Program Toronto General Hospital,Toronto, Ontario, Canada. Dr. Butany is Professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Canada and Director of the Division of Pathology in the Department. He is a Staff Cardiovascular Pathologist at the University Health Network (Toronto General Hospital Site), and Director of Autopsy Services. His investigative work has primarily been based on clinical investigations and outcomes and collaboration with clinical colleagues in basic and applied research. His major interest has been prosthetic heart valves. Dr. Butany has been involved in teaching at the undergraduate and post-graduate levels, including medical students, pathology residents, cardiology residents and cardiac surgery residents and fellows. He is a founding member of the Society for Cardiovascular Pathology and served as the president from 2007-2009). He has been Co-Editor-in-Chief of Cardiovascular Pathology, the official journal of the Society of Cardiovascular Pathology and continues to serve on its Editorial Board.

Affiliations and Expertise

Professor, University of Toronto and Director, Division of Pathology, Deptartment of Laboratory Medicine and Pathobiology, University Health Network / Laboratory Medicine Program Toronto General Hospital, Canada

Ratings and Reviews

Write a review

There are currently no reviews for "Cardiovascular Pathology"