Cardiac Regeneration and Repair - 1st Edition - ISBN: 9781782422990, 9781782424321

Cardiac Regeneration and Repair

1st Edition

Authors: Ren-Ke Li Richard Weisel
eBook ISBN: 9781782424321
Hardcover ISBN: 9781782422990
Imprint: Woodhead Publishing
Published Date: 14th March 2014
Page Count: 926
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Description

Heart disease is the leading cause of death in the United Kingdom and the United States. Advanced cell therapies, tissue engineering and biomaterials technologies now offer the potential to reverse the damage caused by heart disease. The two volumes of Cardiac Regeneration and Repair present a complete picture of our current understanding of cardiac pathologies, and the novel therapies and technologies being developed to address heart disease.

Volume One explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. It highlights new approaches to cell therapy for cardiac regeneration, covering alternative routes of cell delivery, monitoring cell engraftment, and using allogeneic stem cells to restore cardiac function. This volume also explores gene therapy, including ultrasound-targeted or direct gene delivery as well as cell-based gene therapy.

Volume Two surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. This volume also focuses on tissue engineering for cardiac repair, including clinical considerations for cardiac tissue engineering, and explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Key Features

  • Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function
  • Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels.
  • Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration
  • Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

Table of Contents

Volume 1 Part 1 The pathogenesis of congestive heart failure: Cardiac matrix remodeling and heart failure; Cardiac biomechanics and heart dysfunction; Modifying matrix remodeling to prevent heart failure. Part 2 Cell therapy for cardiac regeneration and repair: Optimal cells for cardiac repair and regeneration; Cell delivery routes for cardiac stem cell therapy; Cell therapy to regenerate the ischemic heart; Cell therapy for cardiac repair – bench to bedside and back; Recent advances in cardiac stem cell therapy to restore left ventricular function; Monitoring myocardial functional regeneration following cardiac stem cell application; Feasibility of allogeneic stem cells for heart regeneration; Bone marrow cells and their role in cardiac repair after myocardial infarction. Part 3 Stem cells for cardiac regeneration and repair: Cardiac cell therapy to restore contracting elements; Human embryonic stem cells (hESCs) for heart regeneration; Human pluripotent stem cells (hPSCs) for heart regeneration; Cardiac cell therapy: Current status and future trends. Part 4 Gene therapy for cardiac regeneration and repair: Stem cell and gene therapy for cardiac regeneration; Ultrasound-targeted cardiovascular gene therapy.

Volume 2 Part 1 Biomaterials for cardiac regeneration and repair: Nanotechnology and nanomaterials for cardiac repair; Hydrogels for cardiac repair; Injectable biomaterials for cardiac regeneration and repair; Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration; Endothelial progenitor cell (EPC)-seeded intravascular stents. Part 2 Tissue engineering for cardiac regeneration and repair: Biomaterials and cells for cardiac tissue engineering; Decellularized biologic scaffolds for cardiac repair and regeneration; Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix; Cell sheet engineering for cardiac repair and regeneration; Maturation of functional cardiac tissue patches; Vascularizing engineered tissues for in vivo and in vitro applications; Clinical considerations for cardiac tissue engineering. Part 3 Vascular remodelling for regeneration and repair: Aortic extra cellular matrix (ECM) remodelling; Cell-biomaterial interactions for blood vessel formation; Stem cells in tissue-engineered blood vessels for cardiac repair; Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESA™).

Details

No. of pages:
926
Language:
English
Copyright:
© Woodhead Publishing 2014
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9781782424321
Hardcover ISBN:
9781782422990

About the Author

Ren-Ke Li

Affiliations and Expertise

University of Toronto, Canada

Richard Weisel

Affiliations and Expertise

University of Toronto, Canada