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Cancer - 2nd Edition - ISBN: 9780128195475, 9780128195635


2nd Edition

Oxidative Stress and Dietary Antioxidants

Editors: Victor Preedy Vinood Patel
Hardcover ISBN: 9780128195475
eBook ISBN: 9780128195635
Imprint: Academic Press
Published Date: 14th January 2021
Page Count: 596
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Cancer: Oxidative Stress and Dietary Antioxidants, Second Edition, covers the science of oxidative stress in cancer and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor-mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component. Other sections cover new organ site tumors—skin and liver cancer, the role of polymorphisms, cytochrome p450s, COX gene, fatty acids, apoptosis, T cells and mitochondria, prevention/protection with anthocyanins, esculetin, nanoparticles, and more.

This book is a valuable resource for cancer researchers, oncologists, nutritionists and other members of the biomedical field who are interested in enhancing treatment outcome, improving the quality of life of patients, and developing new treatments in the fight against cancer.

Key Features

  • Encompasses updated, revised and state-of-the-art information to advance cancer research
  • Bridges the gaps between nutrition, oxidative stress, and cancer, presenting a holistic approach for health care and research
  • Contains wide applicability to cancer research, from prevention to novel therapeutics


Cancer researchers; oncologists; nutritionists; pharmacologists

Table of Contents

Section A: Oxidative stress and cancer

1. Paraoxonases, oxidative stress, and breast cancer

Fatma Ceyla Eraldemir and Tuğcan Korak

2. Oxidative stress and prostate cancer

Masaki Shiota

3. Oxidative stress in lung cancer

Amir Mousapasandi, Wei Sheng Joshua Loke, Cristan A. Herbert, and Paul S. Thomas

4. Endogenous antioxidants in the prognosis and treatment of lung cancer

Laurie Freire Boullosa, Jinthe Van Loenhout, and Christophe Deben

5. Oxidative stress in stomach cancer

Hitoshi Tsugawa and Hidekazu Suzuki

6. Oxidative stress and oral cavity cancer

Ayca Ant

7. Oxidative stress, epigenetics, and bladder cancer

Chanchai Boonl

8. Linking oxidative stress and ovarian cancers

Tsukuru Amano and Tokuhiro Chano

9. Redox-dependent mechanisms of carcinogenesis in human papillomavirus infection

Cesira Foppoli and Marzia Perluigi

10. Polymorphisms, antioxidant genes, and cancer

Mazhar Al Zoubi and Alaa Aljabali

11. The interconnection of high-fat diets, oxidative stress, the heart, and carcinogenesis

Bianka Bojková, Natalia Kurhaluk, and Pawel J. Winklewski

12. Cancer during pregnancy. Maternal, placenta, and fetal damage. Nutrition, antioxidant defenses, and adult offspring tumor-bearing

Carla de Moraes Salgado, Natalia Angelo da Silva Miyaguti, Sarah Christine Pereira de Oliveira, Bianca Cristine Favero-Santos, Laís Rosa Viana, Melina de Moraes Santos Oliveira, and Maria Cristina Cintra Gomes-Marcondes

13. Inflammation and oxidatively induced DNA damage: A synergy leading to cancer development

Ioanna Tremi, Somaira Nowsheen, Khaled Aziz, Shankar Siva, Jessica Ventura, Vasiliki I. Hatzi, Olga A. Martin, and Alexandros G. Georgakilas

14. Ferroptosis, free radicals, and cancer

Rui Kang and Daolin Tang

15. Nrf2, YAP, antioxidant potential, and cancer

Giuseppina Barrera, Marie Angele Cucci, Margherita Grattarola, and Stefania Pizzimenti

16. Cancer, NFkappaB, and oxidative stress-dependent phenotypes

Daniela Sorriento, Jessica Gambardella, and Guido Iaccarino

17. 8-Hydroxydeoxyguanosine: A valuable predictor of oxidative DNA damage in cancer and diabetes mellitus

Anmar Al-Taie, Mesut Sancar, and Fikret Vehbi Izzettin

Section B: Antioxidants and cancer

18. Molecular approaches toward targeted cancer therapy with some food plant products: On the role of antioxidants and immune microenvironment

Anisur Rahman Khuda-Bukhsh, Santu Kumar Saha, Sreemanti Das, and Sweta Sharma Saha

19. Prostate cancer and food-based antioxidants in India as plausible therapeutics

Ranjana Bhandari, Garima Khanna, and Anurag Kuhad

20. Linking nonenzymatic antioxidants in the diet and colorectal cancer 219

Esther Molina-Montes, Belén García-Villanova, Eduardo Jesús Guerra-Hernández, and Pilar Amiano

21. Fruit and vegetable juices and breast cancer

Cíntia Ferreira-Pêgo, Bojana B. Vidović , Nuno G. Oliveira, Ana S. Fernandes and João G. Costa

22. Oxidative stress and cancer: Role of n-3 PUFAs

Concetta Finocchiaro, Maurizio Fadda, Valentina D’Onofrio, Mirko Ippolito, Costanza Pira, and Andrea Devecchi

23. Statins, cancer, and oxidative stress

Tahoora Shomali and Mahboobeh Ashrafi

24. Role of anthocyanins in oxidative stress and the prevention of cancer in the digestive system

Elvira Gonzalez de Mejia, Miguel Rebollo-Hernanz, Yolanda Aguilera, and Maria A. Martín-Cabrejas

25. Caffeic Acid targets metabolism of cervical squamous cell carcinoma

Malgorzata Tyszka-Czochara

26. Effects of caffeic acid on oxidative balance and cancer

Beatriz da Silva Rosa Bonadiman, Grazielle Castagna Cezimbra Weis, Jéssica Righi da Rosa, Charles Elias Assmann, < Audrei de Oliveira Alves, Pâmela Longhi, and Margarete Dulce Bagatini

27. Oxidative stress and cancer: Antioxidative role of Ayurvedic plants

Sahdeo Prasad and Sanjay K. Srivastava

28. Polyphenol chlorogenic acid, antioxidant profile, and breast cancer

Onur Bender and Arzu Atalay

29. Cinnamomum cassia, apoptosis, STAT3 inactivation and reactive oxygen species in cancer studies

Yae Jin Yoon and Byoung-Mog Kwon

30. Antioxidative stress actions of cocoa in colonic cancer: Revisited

Sonia Ramos, Luis Goya, and Maria Angeles Martín

31. Medicinal plants, antioxidant potential, and cancer

Emmanuel Mfotie Njoya

32. Curcumin, oxidative stress, and breast cancer

Gloria M. Calaf

33. Curcumin analogs, oxidative stress, and prostate cancer

Marco Bisoffi and Justin M. O’Neill

34. Fern extract, oxidative stress, and skin cancer

Concepción Parrado, Yolanda Gilaberte, Neena Philips, Angeles Juarranz, and Salvador Gonzalez

35. Lycium barbarum (goji berry), human breast cancer, and antioxidant profile

Anna Wawruszak, Marta Halasa, and Karolina Okla

36. Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells

Sadia Afrin, Tamara Y. Forbes-Hernández, Francesca Giampieri, and Maurizio Battino

37. Piplartine (piperlongumine), oxidative stress, and use in cancer

Daniel Pereira Bezerra

38. Antioxidant of Pleurotus ostreatus (Jacq.) P. Kumn and lymphoid cancer cells

Md. Moyen Uddin Pk, Jane O’Sullivan, Rumana Pervin, and Matiar Rahman

39. “Skin cancer, polyphenols, and oxidative stress” or Counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols

Neena Philips, Richard Richardson, Halyna Siomyk, David Bynum, and Salvador Gonzalez

40. Pterostilbene and cancer chemoprevention

Rong-Jane Chen and Ying-Jan Wang

41. Resveratrol, reactive oxygen species, and mesothelioma

Saime Batırel

42. Exercise, selenium, and cancer cells

Mahdieh Molanouri Shamsi and Zuhair Mohammad Hassan

43. Silybum marianum, antioxidant activity, and cancer patients

Sepideh Elyasi

44. Plants of the genus Terminalia: Phytochemical and antioxidant profiles, proliferation, and cancer

Ian Edwin Cock and Matthew Cheesman

45. Uncaria tomentosa: A promising source of therapeutic agents for prevention and treatment of oxidative stress and cancer

Francesca Ciani, Natascia Cocchia, Viola Calabrò, Alessandra Pollice, Lucianna Maruccio, Domenico Carotenuto, Luigi Esposito, Luigi Avallone, and Simona Tafuri

46. Pharmacological ascorbate and use in pancreatic cancer

Rory S. Carroll, Garry R. Buettner, and Joseph J. Cullen

47. Antioxidant vitamins and genetic polymorphisms in breast cancer

Daehee Kang, Sang-Ah Lee, and Woo-Kyoung Shin

48. Antioxidant vitamins in acute lymphoblastic leukemia

Behnaz Abiri and Mohammadreza Vafa

Section C: Online resources

49. Recommended resources on cancer: Oxidative stress and dietary antioxidants

Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy


No. of pages:
© Academic Press 2021
14th January 2021
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Vinood Patel

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, United Kingdom


"This book is a valuable resource for cancer researchers, oncologists, nutritionists and other members of the biomedical field who are interested in enhancing treatment outcome, improving the quality of life of patients, and developing new treatments in the fight against cancer." --Anticancer Research

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