Oxidative Stress and Dietary Antioxidants

2nd Edition - January 14, 2021

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  • Editors: Victor Preedy, Vinood Patel
  • Hardcover ISBN: 9780128195475
  • eBook ISBN: 9780128195635

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Cancer: Oxidative Stress and Dietary Antioxidants, Second Edition, covers the science of oxidative stress in cancer and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor-mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component. Other sections cover new organ site tumors—skin and liver cancer, the role of polymorphisms, cytochrome p450s, COX gene, fatty acids, apoptosis, T cells and mitochondria, prevention/protection with anthocyanins, esculetin, nanoparticles, and more. This book is a valuable resource for cancer researchers, oncologists, nutritionists and other members of the biomedical field who are interested in enhancing treatment outcome, improving the quality of life of patients, and developing new treatments in the fight against cancer.

Key Features

  • Encompasses updated, revised and state-of-the-art information to advance cancer research
  • Bridges the gaps between nutrition, oxidative stress, and cancer, presenting a holistic approach for health care and research
  • Contains wide applicability to cancer research, from prevention to novel therapeutics


Cancer researchers; oncologists; nutritionists; pharmacologists

Table of Contents

  • Section A: Oxidative stress and cancer

    1. Paraoxonases, oxidative stress, and breast cancer

    Fatma Ceyla Eraldemir and Tuğcan Korak

    2. Oxidative stress and prostate cancer

    Masaki Shiota

    3. Oxidative stress in lung cancer

    Amir Mousapasandi, Wei Sheng Joshua Loke, Cristan A. Herbert, and Paul S. Thomas

    4. Endogenous antioxidants in the prognosis and treatment of lung cancer

    Laurie Freire Boullosa, Jinthe Van Loenhout, and Christophe Deben

    5. Oxidative stress in stomach cancer

    Hitoshi Tsugawa and Hidekazu Suzuki

    6. Oxidative stress and oral cavity cancer

    Ayca Ant

    7. Oxidative stress, epigenetics, and bladder cancer

    Chanchai Boonl

    8. Linking oxidative stress and ovarian cancers

    Tsukuru Amano and Tokuhiro Chano

    9. Redox-dependent mechanisms of carcinogenesis in human papillomavirus infection 

    Cesira Foppoli and Marzia Perluigi

    10. Polymorphisms, antioxidant genes, and cancer

    Mazhar Al Zoubi and Alaa Aljabali

    11. The interconnection of high-fat diets, oxidative stress, the heart, and carcinogenesis

    Bianka Bojková, Natalia Kurhaluk, and Pawel J. Winklewski

    12. Cancer during pregnancy. Maternal, placenta, and fetal damage. Nutrition, antioxidant defenses, and adult offspring tumor-bearing

    Carla de Moraes Salgado, Natalia Angelo da Silva Miyaguti, Sarah Christine Pereira de Oliveira, Bianca Cristine Favero-Santos, Laís Rosa Viana, Melina de Moraes Santos Oliveira, and Maria Cristina Cintra Gomes-Marcondes

    13. Inflammation and oxidatively induced DNA damage: A synergy leading to cancer development

    Ioanna Tremi, Somaira Nowsheen, Khaled Aziz, Shankar Siva, Jessica Ventura, Vasiliki I. Hatzi, Olga A. Martin, and Alexandros G. Georgakilas

    14. Ferroptosis, free radicals, and cancer

    Rui Kang and Daolin Tang

    15. Nrf2, YAP, antioxidant potential, and cancer

    Giuseppina Barrera, Marie Angele Cucci, Margherita Grattarola, and Stefania Pizzimenti

    16. Cancer, NFkappaB, and oxidative stress-dependent phenotypes

    Daniela Sorriento, Jessica Gambardella, and Guido Iaccarino

    17. 8-Hydroxydeoxyguanosine: A valuable predictor of oxidative DNA damage in cancer and diabetes mellitus

    Anmar Al-Taie, Mesut Sancar, and Fikret Vehbi Izzettin

    Section B: Antioxidants and cancer

    18. Molecular approaches toward targeted cancer therapy with some food plant products: On the role of antioxidants and immune microenvironment

    Anisur Rahman Khuda-Bukhsh, Santu Kumar Saha, Sreemanti Das, and Sweta Sharma Saha

    19. Prostate cancer and food-based antioxidants in India as plausible therapeutics

    Ranjana Bhandari, Garima Khanna, and Anurag Kuhad

    20. Linking nonenzymatic antioxidants in the diet and colorectal cancer 219

    Esther Molina-Montes, Belén García-Villanova, Eduardo Jesús Guerra-Hernández, and Pilar Amiano

    21. Fruit and vegetable juices and breast cancer

    Cíntia Ferreira-Pêgo, Bojana B. Vidović , Nuno G. Oliveira, Ana S. Fernandes and João G. Costa

    22. Oxidative stress and cancer: Role of n-3 PUFAs

    Concetta Finocchiaro, Maurizio Fadda, Valentina D’Onofrio, Mirko Ippolito, Costanza Pira, and Andrea Devecchi

    23. Statins, cancer, and oxidative stress

    Tahoora Shomali and Mahboobeh Ashrafi

    24. Role of anthocyanins in oxidative stress and the prevention of cancer in the digestive system

    Elvira Gonzalez de Mejia, Miguel Rebollo-Hernanz, Yolanda Aguilera, and Maria A. Martín-Cabrejas

    25. Caffeic Acid targets metabolism of cervical squamous cell carcinoma

    Malgorzata Tyszka-Czochara

    26. Effects of caffeic acid on oxidative balance and cancer

    Beatriz da Silva Rosa Bonadiman, Grazielle Castagna Cezimbra Weis, Jéssica Righi da Rosa, Charles Elias Assmann, < Audrei de Oliveira Alves, Pâmela Longhi, and Margarete Dulce Bagatini

    27. Oxidative stress and cancer: Antioxidative role of Ayurvedic plants

    Sahdeo Prasad and Sanjay K. Srivastava

    28. Polyphenol chlorogenic acid, antioxidant profile, and breast cancer

    Onur Bender and Arzu Atalay

    29. Cinnamomum cassia, apoptosis, STAT3 inactivation and reactive oxygen species in cancer studies

    Yae Jin Yoon and Byoung-Mog Kwon

    30. Antioxidative stress actions of cocoa in colonic cancer: Revisited

    Sonia Ramos, Luis Goya, and Maria Angeles Martín

    31. Medicinal plants, antioxidant potential, and cancer

    Emmanuel Mfotie Njoya

    32. Curcumin, oxidative stress, and breast cancer

    Gloria M. Calaf

    33. Curcumin analogs, oxidative stress, and prostate cancer

    Marco Bisoffi and Justin M. O’Neill

    34. Fern extract, oxidative stress, and skin cancer

    Concepción Parrado, Yolanda Gilaberte, Neena Philips, Angeles Juarranz, and Salvador Gonzalez

    35. Lycium barbarum (goji berry), human breast cancer, and antioxidant profile

    Anna Wawruszak, Marta Halasa, and Karolina Okla

    36. Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells

    Sadia Afrin, Tamara Y. Forbes-Hernández, Francesca Giampieri, and Maurizio Battino

    37. Piplartine (piperlongumine), oxidative stress, and use in cancer

    Daniel Pereira Bezerra

    38. Antioxidant of Pleurotus ostreatus (Jacq.) P. Kumn and lymphoid cancer cells

    Md. Moyen Uddin Pk, Jane O’Sullivan, Rumana Pervin, and Matiar Rahman

    39. “Skin cancer, polyphenols, and oxidative stress” or Counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols

    Neena Philips, Richard Richardson, Halyna Siomyk, David Bynum, and Salvador Gonzalez

    40. Pterostilbene and cancer chemoprevention

    Rong-Jane Chen and Ying-Jan Wang

    41. Resveratrol, reactive oxygen species, and mesothelioma

    Saime Batırel

    42. Exercise, selenium, and cancer cells 

    Mahdieh Molanouri Shamsi and Zuhair Mohammad Hassan

    43. Silybum marianum, antioxidant activity, and cancer patients

    Sepideh Elyasi

    44. Plants of the genus Terminalia: Phytochemical and antioxidant profiles, proliferation, and cancer

    Ian Edwin Cock and Matthew Cheesman

    45. Uncaria tomentosa: A promising source of therapeutic agents for prevention and treatment of oxidative stress and cancer

    Francesca Ciani, Natascia Cocchia, Viola Calabrò, Alessandra Pollice, Lucianna Maruccio, Domenico Carotenuto, Luigi Esposito, Luigi Avallone, and Simona Tafuri

    46. Pharmacological ascorbate and use in pancreatic cancer

    Rory S. Carroll, Garry R. Buettner, and Joseph J. Cullen

    47. Antioxidant vitamins and genetic polymorphisms in breast cancer

    Daehee Kang, Sang-Ah Lee, and Woo-Kyoung Shin

    48. Antioxidant vitamins in acute lymphoblastic leukemia

    Behnaz Abiri and Mohammadreza Vafa

    Section C: Online resources

    49. Recommended resources on cancer: Oxidative stress and dietary antioxidants

    Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy



Product details

  • No. of pages: 596
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: January 14, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128195475
  • eBook ISBN: 9780128195635

About the Editors

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Vinood Patel

Vinood Patel
Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, United Kingdom

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