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Cancer - 1st Edition - ISBN: 9780124052055, 9780124055247


1st Edition

Oxidative Stress and Dietary Antioxidants

Editor: Victor Preedy
eBook ISBN: 9780124055247
Paperback ISBN: 9780128102671
Hardcover ISBN: 9780124052055
Imprint: Academic Press
Published Date: 1st March 2014
Page Count: 308
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Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this.

Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

Key Features

  • Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease
  • Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments
  • Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams
  • Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods


Nutritionists, dieticians, and cancer researchers

Table of Contents


List of Contributors

Section 1 Oxidative Stress and Cancer

Chapter 1. The Role of Oxidative Stress in Breast Cancer


Oxidative Stress as a Driver of Breast Cancer Development and Progression

Oxidative Stress Response and Adaptation Mechanisms in Breast Cancer

Interesting Findings, Limitations, and Future Directions

Concluding Remarks

Summary Points

Chapter 2. Oxidative Stress and Prostate Cancer


Causes of Oxidative Stress in Prostate Cancer

Role of Oxidative Stress in Pathogenesis of Prostate Cancer

Prostate Cancer Risk Factors and Their Links to Oxidative Stress


Summary Points

Chapter 3. Oxidative Stress in Lung Cancer


Lung Cancer

Etiology of Lung Cancer

Tobacco Smoking and Oxidants

Silica and Oxidants

Asbestos and Oxidants

Domestic Cooking and Oxidants

Role of Oxidants in Normal Physiology

Inflammation and Oxidative Stress

Oxidative Stress Leads to DNA Mutations and Lung Cancer

Lipid and Protein Peroxidation

Oxidant/Antioxidant Disequilibrium

Antioxidants and Lung Cancer Chemoprevention


Summary Points

Chapter 4. Oxidative Stress and Stomach Cancer


H. pylori and Oxidative Stress


Nonsteroidal Anti-Inflammatory Drugs and Aspirin

Ischemia/Reperfusion Injury

Reactive Oxygen Species

Reactive Nitrogen Species

Antioxidants and Stomach Cancer


Summary Points

Chapter 5. The Role of Oxidative Stress in Ovarian Cancer: Implications for the Treatment of Patients


Ovarian Biology

Common Ovarian Cancer Mutations Linked to ROS

Antioxidant Mechanisms in the Ovary

Antioxidant Therapies, Ovarian Cancer


Summary Points

Chapter 6. Role of Oxidative Stress in Human Papillomavirus-Driven Cervical Carcinogenesis


Cervical Cancer

HPV Structure

Oxidative Stress and Cervical Cancer

Concluding Remarks

Summary Points

Chapter 7. Inflammation and Oxidative DNA Damage: A Dangerous Synergistic Pathway to Cancer


Oxidative DNA Damage

Role of Inflammation in Induction of Oxidative Stress and DNA Damage Leading to Cancer

Nontargeted Effects, Inflammation, Oxidative Stress and DNA Damage

Radiation-Induced Inflammation


Summary Points

Section 2 Antioxidants and Cancer

Chapter 8. Molecular Approaches Toward Targeted Cancer Therapy with Some Food Plant Products: On the Role of Antioxidants


Oxidative Stress and Reactive Oxygen Species (ROS): The “Rusting Disorder”

Oxidative Stress: Definition, Sources, and Chemistry in General

Cancer: Definition and the Impact of Food and Food Habits

Finding out the Culprit: Genome versus Oxidative Stress

Aims of Targeted Cancer Therapy

Cancer Therapeutics by Targeting Antioxidative Mechanisms

ROS-Related Signaling Pathways for Targeted Cancer Therapy

Carotenoids (Beta Carotene and Lycopene)




Future Perspectives

Summary Points

Chapter 9. Oxidative Stress and Antioxidant Herbs and Spices in Cancer Prevention


Antioxidants in Diet and Human Health

Dietary Phytochemicals as Antioxidants

Antioxidant Phytochemicals and Cancer Prevention

Terpenoids and Cancer Prevention

Chinese Herbs and Cancer Prevention

Summary Points

Chapter 10. The Indian Blackberry (Jamun), Antioxidant Capacity, and Cancer Protection


Extraction and Chemical Composition of Jamun Pulp

Antioxidant Potential of Jamun and Its Components

Antioxidant Activity of Individual Anthocyanidins

Jamun Extracts Inhibit Oxidative DNA Damage

Anticancer Effects of Jamun Bioactives

Efficacy of Jamun in Preventing Estrogen-Mediated Mammary Tumorigenesis

Bioavailability of Berry Bioactives

Availability of Jamun as Functional Foods


Summary Points

Chapter 11. Preventive Effects of Broccoli Bioactives: Role on Oxidative Stress and Cancer Risk


Cruciferous Vegetables Intake and Cancer Risk

Antioxidants and Other Bioactive Compounds in Broccoli

Cancer Preventive Mechanisms of Isothyocianates and Indoles

Modulation of Phase I and Phase II Biotransformation Enzymes

Anti-Inflammatory Activity

Stimulation of Apoptosis

Regulation of Estrogen Receptor

Epigenetic Regulation

Other Mechanisms

Role of Broccoli Intake on Markers of Oxidative Stress and Cancer Risk in Human Intervention Studies: The Case of Smokers

Closing Remarks and Conclusions

Summary Points

Chapter 12. Resveratrol and Lycopene in the Diet and Cancer Prevention





Summary Points

Chapter 13. Iron, Oxidative Stress, and Cancer


Epidemiological Evidences

Iron Homeostasis and Cancer Development: Mechanistic Views

Summary Points

Chapter 14. Role of Black Chokeberries in Breast Cancer: A Focus on Antioxidant Activity

Oxidative Stress in Breast Cancer

Dietary Antioxidants and Their Role in Cancer

Activity of Black Chokeberries in Breast Cancer

Summary Points

Chapter 15. Curcumin, Oxidative Stress, and Breast Cancer


Estrogens (17β-estradiol) and Oxidative Stress

Oxidative Stress

Curcumin as an Antioxidant

Effect of Curcumin on a Multifunctional Nuclear Transcription Factor and Manganese Superoxide Dismutase (MnSOD) Protein Expression

Effects of Curcumin on Lipid Peroxidation

Oxidative Stress and Genomic Instability

Summary Points

Chapter 16. Antioxidant Vitamins and Genetic Polymorphisms in Breast Cancer


Effect of Antioxidant Vitamin on Breast Cancer Incidence

Antioxidant Vitamins and Genomic Integrity: Developmental and Degenerative Correlates

Interaction between Genetic Polymorphism and Antioxidant Vitamins on Breast Cancer Risk

Chapter 17. Dietary Antioxidants in Prostate Cancer


Dietary Antioxidants


Review of Main Points

Chapter 18. Curcumin Analogs, Oxidative Stress, and Prostate Cancer


Prostate Cancer and Oxidative Stress

Curcumin, Curcuminoids, and Curcumin Analogs

The Potential of Curcumin, Curcuminoids, and Curcumin Analogs as Oxidant Agents in Prostate Cancer

Summary Points

Chapter 19. Oxidative Stress and Inflammatory Factors in Lung Cancer: Role of n-3 PUFAs


General Information Concerning EPA and DHA


Summary Points

Chapter 20. Antioxidative Stress Actions of Cocoa in Colonic Cancer


Chemopreventive Mechanism of Cocoa Polyphenols in Cultured Colon Cancer Cells

Chemopreventive Mechanism of Cocoa in an In Vivo Model of Colon Cancer

Human Studies

Summary Points

Chapter 21. Green Tea Polyphenols and Reduction of Oxidative Stress in Liver Cancer


Oxidative Stress Associated with HCCs

Antitumor Effects of GTPs

Combined Effects of Green Tea and Anticancer Drugs

Metabolism of GTPs in the Human Body

Previous Reports of GTPs and HTLV-1-Associated T-Cell Leukemia (Adult T-Cell Leukemia)

Controversial Results Concerning the Efficacy of GTPs

Summary Points

Chapter 22. Quercetin’s Potential to Prevent and Inhibit Oxidative Stress-Induced Liver Cancer


Role of Oxidative Stress in the Development of Liver Cancer

Antioxidants as the Oxidative Stress Scavenger

Summary Points

Chapter 23. Capsaicin Mediated Oxidative Stress in Pancreatic Cancer


Apoptotic Pathways

ROS and ETC Complex in the Mitochondria

Thioredoxin and Ask-1 Signaling Pathway

Suppression of Pancreatitis by Capsaicin

Summary Points

Chapter 24. Tocotrienols in Pancreatic Cancer Treatment and Prevention


Source of Tocotrienols

Use of Tocotrienols in Cancer

Oxidative Stress in Cancer and the Preventive Role of Tocotrienols

Effect of Tocotrienols in Mediating Cellular Pathways

Tocotrienols in Pancreatic Cancer

In Vitro Data in Pancreatic Cancer

In Vivo Data in Pancreatic Cancer

Conclusion and Future Direction

Summary Points

Chapter 25. Fern Extract, Oxidative Stress, and Skin Cancer


Photoprotective Agents

Molecular, Cellular, and Clinical Evidence of Antioxidant Properties of Fernblock®

Potential Use of Fernblock® in the Treatment of Other Pathological Skin Conditions

Fernblock: A Road to (Present and Future) Photoprotection

Summary Points

Chapter 26. Skin Cancer, Polyphenols, and Oxidative Stress


Oxidative Stress, Inflammation, and Associated Signal Transduction Pathways: Fundamental Biology, the Alteration, and Counteraction by Polyphenols

ECM Remodeling and Associated Growth Factors: Fundamental Biology, the Alteration, and Counteraction by Polyphenols


Summary Points

Chapter 27. Pterostilbene Protection and Bladder Cancer Cells



Pterostilbene and Bladder Cancer

Summary Points


Color Plates


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© Academic Press 2014
1st March 2014
Academic Press
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About the Editor

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Ratings and Reviews