COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Cancer-Leading Proteases - 1st Edition - ISBN: 9780128181683, 9780128181690

Cancer-Leading Proteases

1st Edition

Structures, Functions, and Inhibition

Editor: Satya Gupta
eBook ISBN: 9780128181690
Paperback ISBN: 9780128181683
Imprint: Academic Press
Published Date: 9th January 2020
Page Count: 523
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers.

In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases.

Key Features

  • Explains the role of proteases in the biology of cancer
  • Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers
  • Covers a wide range of cancers and provides detailed discussions on protease examples


Pharmaceutical Scientists, Cancer Researchers, Molecular Biologists, Medical Chemists; Researchers and Students working with proteases

Table of Contents

  1. Proteases and Their Biological Roles and Mechanism of Action
    2. Specificity and Diversity in Proteases
    3. Potential Roles of Protease Inhibitors in Cancer Progression
    4. Serine Proteases in Ovarian Cancer
    5. Aspartic Proteases as Potential Drug Targets for Anticancer Drug Development
    6. Design and Development of Serine Proteases Acting against Prostate Cancer
    7. Urokinase and Colorectal Carcinoma: Studies on Mechanism and Inhibition
    8. Overexpression of Cystein Proteases and Colorectal Carcinoma
    9. Studies on Cystein Proteases and Their Inhibitors for Anti-cancer Drug Design
    10. Gelatinases and Anticancer Drug Development
    11. HCV NS3 Serine Protease as a Drug Target for Development of Drugs Against Liver Cancer
    12. Molecular Imaging of Proteases in Cancer


No. of pages:
© Academic Press 2020
9th January 2020
Academic Press
eBook ISBN:
Paperback ISBN:

About the Editor

Satya Gupta

Satya P. Gupta is presently a Professor Emeritus at Meerut Institute of Engineering and Technology (MIET), Meerut, India, after retiring as Professor in the Department of Applied Sciences at National Institute of Technical Teachers’ Training and Research (NITTTR), Bhopal. Earlier he served Tata Institute of Fundamental Research (TIFR), Mumbai, a world renowned Institution of India, Birla Institute of Technology and Science (BITS), Pilani, and then (MIET) as its Director-cum Professor of Eminence in the Department of Pharmacy. Professor Gupta has a very long standing of teaching Quantum Chemistry, Pharmaceutical Chemistry, Biophysics, and Drug Design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, in 1967 and 1971, respectively. He is a world renowned scientist. For his work in Drug Design, he has bagged several honors and awards. To his credit, Gupta has more than 200 research publications in highly reputed national and international journals and several reviews in such highly prestigious periodicals as Chemical Reviews (American Chemical Society), Progress in Drug Research (Birkhäuser Verlag Basel, Switzerland), and Current Medicinal Chemistry (Bentham Science, Netherlands), and has been on editorial board of several international journals. Dr. Gupta himself has been editor of several scientific journals and books of international repute published by Springer Verlag, Heidelberg Germany; CRC Press, Taylor and Francis Group; Nova Science Publishers, NY, USA; and Elsevier (Academic Press), USA. He has delivered several lectures on Drug Design across the world. His scientific activity has brought him on the forefront of scientific community of the world.

Affiliations and Expertise

Professor Emeritus, Department of Applied Sciences, National Institute of Technical Teachers’ Training and Research, India Fellow, National Academy of Sciences, India

Ratings and Reviews