Cancer Immunotherapy in Urology, An Issue of Urologic Clinics

1st Edition, Volume 47-4 - October 12, 2020
Editors: Sujit S Nair, Ashutosh Tewari
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 5 4 9 8 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 5 4 9 9 - 6

The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer… Read more

Cancer Immunotherapy in Urology, An Issue of Urologic Clinics

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The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.

Cover image
Title page
Table of Contents
Copyright
Contributors
Urologic Clinics of North America
Preface
William B. Coley: His Hypothesis, His Toxin, and the Birth of Immunotherapy
Key points
Introduction
Early immunotherapy
William B. Coley: “The most opportune time in a thousand years”
Bacilli Calmette-Guérin: Urology’s immunotherapy success story
The landmarks of immunologic discovery that provided the foundation for immunotherapy
Checkpoint inhibitors
Kidney Cancer: An Overview of Current Therapeutic Approaches
Key points
Introduction
First-line combination therapies for metastatic renal cell carcinoma
Second-line treatment strategies for metastatic renal cell carcinoma
Adjuvant treatment in renal cell carcinoma
Neoadjuvant therapy in renal cell carcinoma
Future directions
Summary
Harnessing Natural Killer Cell Function for Genitourinary Cancers
Key points
Background
Natural killer cells in bladder cancer
Natural killer cells in kidney cancer
Natural killer cells in prostate cancer
Summary
Clinical care points
Immunotherapy for Localized Prostate Cancer: The Next Frontier?
Key points
Introduction
Overview of the immune response and cancer
Strategies for cancer immunotherapy
Immunotherapy considerations for prostate cancer
ProstVac-VF
Sipuleucel-T
Checkpoint inhibitor immunotherapy
Future directions
funding
Summary
The Potential Role for Immunotherapy in Biochemically Recurrent Prostate Cancer
Key points
Introduction
Patient selection and timing of therapy
The role of immunotherapy in prostate cancer
Rationale for immunotherapy in biochemically recurrent prostate cancer
Selected studies of immunotherapy in biochemically recurrent prostate cancer
Immunotherapy for Prostate Cancer: Treatments for the “Lethal” Phenotype
Key points
Introduction
Targeting the tumor microenvironment: a challenge?
Lethal prostate cancer: does it exist and can we treat it?
Treating the “lethal” phenotype based on genomics
Immunotherapy in prime time: the role of biomarkers
Discussion
Application of Single-Cell Sequencing to Immunotherapy
Key points
Introduction
Heterogeneity in urologic cancers
Overview of single-cell sequencing approaches
Technical considerations in single-cell sequencing
Emerging technologies
Summary
Clinical comments
Immunotherapy for Metastatic Prostate Cancer: Current and Emerging Treatment Options
Key points
Progression
Immunotherapy in cancer
Immunotherapy in genitourinary cancers
Immunotherapy in bladder cancer
Immunotherapy for metastatic prostate cancer
Preclinical models for immunotherapy research for metastatic prostate cancer
Future directions: combination therapy of vaccines and checkpoint inhibitors, with molecularly driven approaches
Biotech and Breakthroughs in Immuno-Oncology
Key points
Special Article
Personalized Medicine for the Infertile Male
Key points
Introduction
Standard male infertility workup: what is the standard male infertility workup
Spermatogenesis failure: the future for spermatogonia stem cell transplantation and genomic editing
Seminal plasma (proteomics)
Epigenetics (epigenomics)
Susceptibility genes to environmental factors in male infertility
Summary