Calcium-Binding Proteins in Health and Disease

Calcium-Binding Proteins in Health and Disease

1st Edition - January 1, 1987

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  • Editor: Anthony Norman
  • eBook ISBN: 9780323141420

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Calcium-Binding Proteins in Health and Disease includes the papers prepared by the invited speakers as well as many of the free communications. The contributions are grouped according to their general subject matter, based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis; Low-Affinity Calcium-Binding Proteins. There can be little doubt that calcium-binding proteins is a field of scientific endeavor which will continue to produce results of great interest to modern biology. This book is divided into eight sections, the first of which, tackle extracellular calcium metabolism or calcium homeostasis. The next sections focus on topics such as low-affinity calcium-binding proteins; calcium and membranes, channels and transport (pumps); the role of calcium in complex metabolic processes; and gene structure of calcium-binding proteins and their expression. Other chapters cover physical studies on calcium-binding proteins, including X-ray, crystallography, and NMR; structure-function relationships of calcium-binding proteins and their targets; and calcium-binding proteins in health and disease. This book will be of interest to practitioners in the fields of biology and medicine.

Table of Contents

  • Preface

    Delegate Group

    Extracellular Calcium Metabolism: Calcium Homeostasis

    Developmental Control of a Calcium-Regulating Neuroendocrine Gene

    The Vitamin D Endocrine System: Pleiotropic Interactions Which Contribute to Calcium Homeostasis

    Calbindin-D28k in the Circulatory System of the Chick

    Spermine Evokes the Rapid Mobilization of Cellular Ca2+ in Parathyroid Cells

    Evidence for the Presence of a Novel Ca2+-Bindingprotein (Ca2+ Receptor) on the Surface of Parathyroid Cells

    Low-Affinity Calcium-Binding Proteins

    Biosynthesis of Vitamin K-Dependent Proteins

    Vitamin K-Dependent Calcium Binding Proteins of the Extracellular Bone Matrix


    Calcium and Membranes, Channels and/or Transport (Pumps)

    Single-File Positioning of Two Calcium ions in the Transport Channel of a Calcium Pump

    The Calcium Pump of the Plasma Membrane: Recent Studies on the Purified Enzyme and on Its Proteolytic Fragments, with Particular Attention to the Calmodulin-Binding Domain

    The Structure of Phospholamban and Its Role in Activating Calcium Transport in the Sarcoplasmic Reticulum

    The Vitamin D-Dependent Ca-Binding Proteins Assure Active Ca Transport in Intestine and Kidney

    Gastric Ca2+ of Mg2+-ATPase: Relationship with H+, K+-ATPase

    Functional Analysis of the Intracellular Ca2+-Regulating System

    A Novel Calmodulin Derivative: Studies with Cardiac Sarcoplasmic Reticulum

    Ligand-Gated Ca2+ Release Channels of the Sarcoplasmic Reticulum: Elucidating Structure and Function with [3H]Ryanodine

    Calbindin-D28k and Calmodulin Regulation of Calcium Transport by Chick Duodenal Basolateral Membranes

    Modification of Histidine Uncouples Cooperativity of Calcium Binding to the Ca?Mg?ATPase of Sarcoplasmic Reticulum

    ATP-Dependent Calcium Uptake by Duodenal Basolateral Membranes from Developing Rats

    Membranes of Sarcoplasmic Reticulum and Red Blood Cells May Have a Common Gene: a New Possibility of Using Blood for Noninvasive Screening for Malignant Hyperthermia

    Effects of Ca-Binding Proteins on Vesicular Ca Transportby Rat Intestinal Basolateral Membranes

    Isolated Sarcoplasmic Reticulum Converts Fura2AM into a Calcium-Independent Analog of Fura2

    Kinetic Parameters of Calmodulin-Activated Calcium ATPase in Erythrocyte Membranes of Normal and Psychiatrically Ill Subjects

    Calcium: Role in Complex Metabolic Processes(Intracellular Ca2+ Recognition)

    Insulin Actionis Associated with the Phosphorylation of Calmodulin

    Calcium and Inositol Trisphosphate

    Calcimedins: Novel Calcium-Binding Proteins

    Calcium Triggering

    New Model for Ca2+ Binding by the Sarcoplasmic Reticulum Ca2+ Pump

    Molecular Pharmacology of Myosin Light Chain Phosphorylation of Smooth Muscle and Nonmuscle Cells

    Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II by Autophosphorylation/Dephosphorylation

    Calcium-Dependent Hydrophobic Interaction Chromatography:Isolation of Several Bovine Brain Calcium-Binding Proteins

    Regulation of Calcium-Dependent Protease Activity In Vitro

    Ca2+ Regulation of Thyroid NADPH-Dependent H2O2 Generation through the Release of an Inhibitor Protein

    Stimulation of Glucose Transport by Insulin, Vanadate, Concanavalin A, Hydrogen Peroxide, and Phorbol Ester Occur by a Calcium-Dependent Mechanism

    Gene Structure of Calcium-Binding Proteins and Their Expression

    Analysis of the Rat 9k Vitamin D-Dependent CaBP Gene

    Calbindin Gene Structure and Expression in Tissues and Cells: Implications for Vitamin D Action in Rat GH3 Cells

    Electron Microscope Study of the Calbindin Gene Organisation

    Molecular Analysis of Calmodulin-Dependent Myosin Light Chain Kinase from Chicken Smooth Muscle

    Structure and Expression of the Sea Urchin Specgenes

    Structural Organization of the Parvalbumin Gene

    Cloning and Expression of cDNAs Coding for the Bioluminescent Protein, Aequorin

    Functional Analysis of the Chicken Calmodulin Promoter

    Use of Genetically Engineered Calmodulins as Structure-Function Probes

    Molecular Cloning and Regulation of the Mammalian 28,000 M Vitamin D-Dependent Calcium-Binding Protein (Calbindin D28k)

    A Novel Calbtndin-Related Gene with Localized Expression in Chick Retina and Brain

    Control of Parvalbumin Expression in Rat Skeletal Muscle by Motor-Unit Specific Activity Patterns

    The Nucleic Acids for Oncomodulin

    Cell-Free Translation of Rat Skin Calcium-Binding Protein Messenger RNA

    Levels of Calmodulin are Strictly Regulated in Cells Transfected with an Exogenous CaM Gene: Effects on Endogenous CaM Regulation and Cell Cycle Progression

    Structure of the Drosophila Calmodulin Gene

    Physical Studies on Calcium-Binding Proteins (X-Ray Crystallography, NMR, etc.)

    Crystal Structure of Calmodulin

    Conformational Flexibility of Troponin C

    Some Thoughts Regarding EF-Hands and the Structure of Calbindins

    1H NMR Studies of Calmodulin-Peptide Interactions

    Structure-Function Relations in EF-Hand Ca2+-Binding Proteins: Genetic Engineering and Biophysical Studies of Bovine Intestinal Calcium Protein (ICaBP)

    1H NMR Structural Studies of a Complex of Melittin with Perdeuterated Calmodulin

    The 2-Zinc Insulin Hexamer is a Calcium-Binding Protein

    The Molecular Structure of the Magnesium Complex of Chicken Skeletal Troponin-C

    Studies on the Binding of Synexin to Phospholipid Vesicles

    Comparative Metal Ion Binding Properties of the ?-Subunit of S-100a and the Parent Molecule Using Fluorescence Spectroscopy

    Metal Ion Binding Properties of Nitrated S-100b Protein

    Calmodulin from Various Sources as Studied by Different NMR Techniques

    NMR Studies of Metal Ion Binding to ?-Lactalbumin: Localization of Calcium and Zinc Binding Site

    NMR Measurements of Methionine Surface Exposure in Calcium-Binding Proteins

    A Time-Resolved Nanosecond Fluorescence Study of S100b: the Effect of Ph, Ca(II), and Zn(II)

    A Time-Resolved Nanosecond Fluorescence Study of Bovine Testes Calmodulin: the Effect of Ph and Ca(II)

    The Effect on the Metal-Binding Affinity of Total Charge and Charge Permutation at the Liganding Positions of Synthetic Calcium-Binding Analogues of Site III of Rabbit Skeletal Troponin C

    Comparative Hydrodynamic Properties of Rabbit Skeletal and Bovine Cardiac Troponin C and Bovine Brain Calmodulin

    Studies on Two High-Affinity, Calcium-Binding Proteins in Squid Optic Lobe

    Hydrogen-Exchange Studies of Calmodulin

    1H FT NMR Studies of the Co3+-Substituted Hexamer: Characterization of Metal Ion Binding to the Glu(B13) Site

    Two-Dimensional 1H NMR Studies of the Structure of Parvalbumin in Solution

    Magnesium Binding to Calcium-Binding Proteins: a Regulatory Function?

    Comparative Molecular Modeling of the Ca++ Sensitive Regulatory Protein Calmodulin Based on Turkey Skeletal TNC

    Structural Studies on Calbindin-D28k

    pH-Dependent Changes in the Spatial Relationship between the Domains of Troponin C

    Local Site Structure and Affinity in Calcium-Binding Proteins: a XANES and EXAFS Study

    Regulatory and Target-Binding Domains of Calmodulin

    Decavanadate-Induced Two-Dimensional Crystals of Sarcoplasmic Reticulum: Inhibition by Myotoxin a

    Structure-Function Relationships of Calcium-Binding Protein Sand Their Targets

    Phospholipase A2 Inhibitory Proteins of Bovine Lung

    Structure and Evolution of Calbindin D28

    Calmodulin Stimulated Adenylate Cyclase from Bovine Brain

    1,25-Dihydroxyvitamin D3 Regulates Calbindin-D28K Expression at the Transcriptional Level

    The Domain Structure of Calcineurin

    Calmodulin as a Substrate and Activator of Protein Methylation

    Organization of Myosin Light Chain Kinase from Rabbit Skeletal Muscle

    Structure and Function of Calmodulin-Dependent Phosphodiesterase Isozymes

    Promoter Selection and Alternative Pre-mRNA Splicing are Used to Generate Complex Contractile Protein Phenotypes

    An Interdisciplinary Approach to the Molecular Mechanisms of Calmodulin Action: Comparative Biochemistry, Site-Specific Mutagenesis, and Protein Engineering

    Structural Studies, Molecular Cloning, and Localization of the Plasma Membrane Ca2+-Pumping ATPase

    S100b Protein: Calcium-Binding Properties and Ca2+-Dependent Interactions with the Microtubule Associated Tau Proteins: S100b Regulates Tau Phosphorylation by Protein Kinase C

    Identification of a 48,000 Dalton Calcium-Binding Protein as a Substrate of Tyrosine-Protein Kinase

    A New Ca2+-Vector Protein in Amphioxus Muscle: General Characterization and Primary Structure

    Small Calcium-Binding Proteins and 1,25-Dihydroxyvitamin D Receptor Distribution

    Disulphide-Linked Dimer of Oncomodulin: Structural and Functional Properties

    Analysis of Troponin T Isoforms

    Parvalbumin Levels of Neurons, Endocrine and Muscle Cells Vary Directly with Levels of Cell Activity

    Comparison of the Metal Ion Binding Sites in Rat Oncomodulin and Parvalbumin

    Calbindin D28K is Highly Conserved during Phylogeny

    Localization of S100 Alpha in Mammalian Kidney

    Calcium-Dependent Functional Hydrophobic Regions of Calcium-Modulated Proteins

    Cholecalcin (28-kDa Calcium-Binding Protein) in Granule and Pyramidal Cells of the Developing Rat Hippocampus: the Protein is Expressed When the Cells Become Functional

    Calcium-Binding Proteins in Health and Disease

    Oncomodulin in Health and Disease

    Cardiac-Troponin C: Relationship between Ca2+-Binding and Force Development

    67k Calcimedin: Does It Function in the Macrophage Inflammatory Response

    Tumor-Associated Calcium-Binding Proteins as Markers in Chemically Transformed and in Growth Stimulated Fibroblasts

    Characterization of Calcium-Dependent Chromaffin Granule-Binding Proteins

    Calbindin-D28K Distribution in Chick Ultimobranchial and Rat Thyroid Glands

    Ultrastructural Localization of Calbindin-D28K in Chick Intestine following 1,25(OH)2D3

    Calbindin D28K and Animal Models of Epilepsy

    Potentiation of Bleomycin Lethality and Inhibition of DNA Repair by Anticalmodulin Drugs is Associated with the Selective Inhibition of Expression of a 55-kDa Calmodulin-Binding Protein

    Author Index

    Subject Index

Product details

  • No. of pages: 650
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: January 1, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9780323141420

About the Editor

Anthony Norman

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