Calcium and Cell Function - 1st Edition - ISBN: 9780121714055, 9781483281988

Calcium and Cell Function

1st Edition

Editors: Wai Yiu Cheung
eBook ISBN: 9781483281988
Imprint: Academic Press
Published Date: 28th December 1984
Page Count: 330
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Calcium and Cell Function, Volume V emphasizes the roles of calcium in cellular functions. This book consists of eight chapters. Chapter 1 presents evidence for the role of calmodulin in cell proliferation. The role of calcium in the control of cyclic AMP metabolism in glial and pituitary tumor cells is analyzed in Chapter 2. Chapter 3 explains the evidence that calmodulin regulates neurotransmitter synthesis, while Chapter 4 deliberates the role of calcium in adipocytes. Chapter 5 is devoted to the modulatory function of lipomodulin in cellular phospholipid metabolism. The pharmacological properties of naphthalenesulfonamides as calmodulin antagonists, phophorylase kinase, and phospholipidsensitive calcium-dependent protein kinase are reviewed in the last chapters. This volume is valuable to biologists and medical practitioners interested in calcium and cell function.

Table of Contents

Contributors Preface Contents of Previous Volumes Chapter 1 Molecular Properties of Phosphorylase Kinase I. Introduction II. Molecular Characteristics III. Regulation of Enzyme Activity IV. Enzymic Reaction Mechanism V. Substrate Specificity References Chapter 2 Phospholipid-Sensitive Ca2 + -Dependent Protein Phosphorylation I. Introduction II. Occurrence and Distribution III. Purification and General Properties IV. Mechanism of Activation V. Substrate Specificity VI. Regulation by Various Agents VII. Perspectives References Chapter 3 Role of Calmodulin in Neurotransmitter Synthesis I. Introduction II. Discovery of Calmodulin-Dependent Protein Kinase II III. Assay of Calmodulin-Dependent Protein Kinase II IV. Purification of Calmodulin-Dependent Protein Kinase II V. Properties of Calmodulin-Dependent Protein Kinase II VI. Distribution of Calmodulin-Dependent Protein Kinase II VII. Substrates of Calmodulin-Dependent Protein Kinase II VIII. Activator Protein IX. Concluding Remarks References Chapter 4 Evidence for a Role for Calmodulin in Cell Proliferation Involving the DNA Repair Pathway I. Introduction II. Anticalmodulin Drugs III. Cell Survival in Response to W-13 IV. Effect of W-13 on Reentry of Quiescent Cells into the Cell Cycle V. Changes in Calmodulin during Plateau Reentry VI. Comparisons of Calmodulin Changes in Exponentially Growing and Plateau-Related Cells VII. Bleomycins VIII. Potentiation of Bleomycin-Induced Cell Death by W-13 IX. Effect of W-13 on Recovery from Bleomycin-Induced Potentially Lethal Damage X. Conclusions and Reflections References Chapter 5 Biopharmacological Properties of Naphthalenesulfonamides as Potent Calmodulin Antagonists I. Introduction II. Antagonism of Calmodulin by Various Compounds III. Anta


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© Academic Press 1984
Academic Press
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About the Editor

Wai Yiu Cheung

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