Calcium and Cell Function

Calcium and Cell Function

1st Edition - December 28, 1984

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  • Editor: Wai Yiu Cheung
  • eBook ISBN: 9781483281988

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Calcium and Cell Function, Volume V emphasizes the roles of calcium in cellular functions. This book consists of eight chapters. Chapter 1 presents evidence for the role of calmodulin in cell proliferation. The role of calcium in the control of cyclic AMP metabolism in glial and pituitary tumor cells is analyzed in Chapter 2. Chapter 3 explains the evidence that calmodulin regulates neurotransmitter synthesis, while Chapter 4 deliberates the role of calcium in adipocytes. Chapter 5 is devoted to the modulatory function of lipomodulin in cellular phospholipid metabolism. The pharmacological properties of naphthalenesulfonamides as calmodulin antagonists, phophorylase kinase, and phospholipidsensitive calcium-dependent protein kinase are reviewed in the last chapters. This volume is valuable to biologists and medical practitioners interested in calcium and cell function.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    Chapter 1 Molecular Properties of Phosphorylase Kinase

    I. Introduction

    II. Molecular Characteristics

    III. Regulation of Enzyme Activity

    IV. Enzymic Reaction Mechanism

    V. Substrate Specificity


    Chapter 2 Phospholipid-Sensitive Ca2 + -Dependent Protein Phosphorylation

    I. Introduction

    II. Occurrence and Distribution

    III. Purification and General Properties

    IV. Mechanism of Activation

    V. Substrate Specificity

    VI. Regulation by Various Agents

    VII. Perspectives


    Chapter 3 Role of Calmodulin in Neurotransmitter Synthesis

    I. Introduction

    II. Discovery of Calmodulin-Dependent Protein Kinase II

    III. Assay of Calmodulin-Dependent Protein Kinase II

    IV. Purification of Calmodulin-Dependent Protein Kinase II

    V. Properties of Calmodulin-Dependent Protein Kinase II

    VI. Distribution of Calmodulin-Dependent Protein Kinase II

    VII. Substrates of Calmodulin-Dependent Protein Kinase II

    VIII. Activator Protein

    IX. Concluding Remarks


    Chapter 4 Evidence for a Role for Calmodulin in Cell Proliferation Involving the DNA Repair Pathway

    I. Introduction

    II. Anticalmodulin Drugs

    III. Cell Survival in Response to W-13

    IV. Effect of W-13 on Reentry of Quiescent Cells into the Cell Cycle

    V. Changes in Calmodulin during Plateau Reentry

    VI. Comparisons of Calmodulin Changes in Exponentially Growing and Plateau-Related Cells

    VII. Bleomycins

    VIII. Potentiation of Bleomycin-Induced Cell Death by W-13

    IX. Effect of W-13 on Recovery from Bleomycin-Induced Potentially Lethal Damage

    X. Conclusions and Reflections


    Chapter 5 Biopharmacological Properties of Naphthalenesulfonamides as Potent Calmodulin Antagonists

    I. Introduction

    II. Antagonism of Calmodulin by Various Compounds

    III. Antagonism of Calmodulin Activity by W-7

    IV. Structure-Activity Relationship of Naphthalenesulfonamides

    V. Other Effects of Naphthalenesulfonamides

    VI. Pharmacological Properties of Naphthalenesulfonamides as Calmodulin Antagonists

    VII. Summary and Conclusions


    Chapter 6 Calcium Control of Cyclic AMP Metabolism in Glial and Pituitary Tumor Cells

    I. Introduction

    II. The C6 Glial Tumor Cell

    III. The Human Astrocytoma Cell Line 1321N1

    IV. Neuroblastoma-Glioma Hybrids

    V. The GH3 Pituitary Tumor Cell

    VI. Summary


    Chapter 7 Calcium and the Adipocyte

    I. Introduction

    II. Calcium Content and Fluxes

    III. Calcium Homeostasis by Subcellular Organelles

    IV. The Role of Calcium in the Regulation of Adipocyte Metabolism

    V. The Role of Calcium in the Mechanism of Insulin Action


    Chapter 8 Lipomodulin: A Modulator of Cellular Phospholipid Metabolism

    I. The Modulation of Receptor Functions by Glucocorticoids

    II. Lipomodulin

    III. Regulation of Arachidonic Acid Release in Intact Cells by Lipomodulin

    IV. Biological Roles of Lipomodulin

    V. Summary



Product details

  • No. of pages: 330
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: December 28, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9781483281988

About the Editor

Wai Yiu Cheung

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