Calcium and Cell Function - 1st Edition - ISBN: 9780121714017, 9781483217468

Calcium and Cell Function

1st Edition

Volume 1

Editors: Wai Yiu Cheung
eBook ISBN: 9781483217468
Imprint: Academic Press
Published Date: 28th November 1980
Page Count: 412
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Calcium and Cell Function, Volume I: Calmodulin covers calmodulin-regulated functions. The book discusses the preparation, properties, structure, function, evolution, and structure-function relationships of calmodulin; and calmodulin-dependent adenylate cyclase. The text also describes the transport of calmodulin and plasma membrane calcium; the role of calmodulin and troponin in the regulation of phosphorylase kinase from mammalian skeletal muscle; and calcium-dependent protein phosphorylation in mammalian brain and other tissues. The role of calmodulin in dopaminergic transmission; the immunocytochemical localization of calmodulin in rat tissues; and the immunocytochemical studies of the localization of calmodulin and caM-BP80 in the brain are also considered. The book further tackles the mechanisms and pharmacological implications of altering calmodulin activity. Molecular cardiologists, biochemists, and pharmacologists will find the book invaluable.

Table of Contents

List of Contributors


Chapter 1 Calmodulin—An Introduction

I. Discovery of Calmodulin

II. Calmodulin as a Multifunctional Regulatory Protein

III. Calmodulin as a Proper Name

IV. Epilogue


Chapter 2 Assay, Preparation, and Properties of Calmodulin

I. Introduction

II. Materials

III. Assay of Calmodulin

IV. Preparation of Calmodulin

V. Properties of Calmodulin

VI. Concluding Remarks


Chapter 3 Structure, Function, and Evolution of Calmodulin

I. Introduction

II. General Physicochemical Properties of Calmodulins

III. Structural Studies of Calmodulin

IV. Similarities between Calmodulin and Troponin C

V. Concluding Remarks


Chapter 4 Calmodulin: Structure-Function Relationships

I. Introduction

II. Calmodulin Structure

III. Physicochemical Properties

IV. Interaction of Calmodulin with Its Target Proteins

V. Conclusions


Chapter 5 Ca2+-Dependent Cyclic Nucleotide Phosphodiesterase

I. Introduction

II. Assay

III. Preparation and Purification

IV. Multiple Molecular Forms of Phosphodiesterase

V. Distribution

VI. General Properties

VII. Kinetic Parameters

VIII. Effectors

IX. Ca2+-Dependent Activation by Calmodulin

X. Concluding Remarks


Chapter 6 Calmodulin-Dependent Adenylate Cyclase

I. Adenylate Cyclase and Divalent Cations

II. Calmodulin-Dependent Adenvlate Cyclase

III. Concluding Remarks


Chapter 7 Calmodulin and Plasma Membrane Calcium Transport

I. Membrane Ca2+ Transport

II. (Ca2+ + Mg2+)-ATPase

III. Calmodulin and Ca2+ Transport

IV. Regulation of the Erythrocyte Plasma Membrane Ca2+ Pump

V. Conclusions


Chapter 8 Smooth Muscle Myosin Light Chain Kinase

I. Introduction

II. Smooth Muscle Myosin Light Chain Kinase (Myosin Kinase)

III. Summary: Regulation of Smooth Muscle Contraction


Chapter 9 The Role of Calmodulin and Troponin in the Regulation of Phosphorylase Kinase from Mammalian Skeletal Muscle

I. Introduction

II. Regulation of Phosphorylase Kinase by Calcium Ions and Identification of Calmodulin as a Subunit

III. Identification of the δ Subunit of Phosphorylase Kinase as Calmodulin

IV. Molar Proportion of the δ Subunit and Its Interaction with Phosphorylase Kinase

V. Evidence That the δ Subunit Is the Component Which Confers Calcium Sensitivity to the Phosphorylase Kinase Reaction

VI. Phosphorylase Kinase Contains a Second Calmodulin-Binding Site Which Activates the Enzyme

VII. Troponin C and the Troponin Complex—Substitutes for the Second Molecule of Calmodulin in the Activation of Phosphorylase Kinase

VIII. Influence of the Second Molecule of Calmodulin and Troponin on the Activity of Phosphorylase Kinase

IX. Proportion of the Calmodulin in Skeletal Muscle That Is Bound to Phosphorylase Kinase

X. Does Troponin C or the Second Molecule of Calmodulin Activate Phosphorylase Kinase in Vivo

XI. Phosphorylation of Glycogen Synthase by Phosphorylase Kinase

XII. Summary


Chapter 10 Plant and Fungal Calmodulin and the Regulation of Plant NAD Kinase

I. Introduction

II. Isolation of Calmodulin by Fluphenazine-Sepharose Chromatography

III. Properties of Plant and Fungal Calmodulin

IV. Activation of Plant NAD Kinase by Calmodulin

V. Significance of Plant and Fungal Calmodulin


Chapter 11 Calcium-Dependent Protein Phosphorylation in Mammalian Brain and Other Tissues

I. Introduction

II. Calcium-Regulated Protein Phosphorylation

III. Calcium- and Calmodulin-Dependent Protein Kinase

IV. Comparison of cAMP-Regulated and Calcium-Regulated Phosphorylation of Protein I

V. Widespread Occurrence of Calcium- and Calmodulin-Dependent Protein Phosphorylation

VI. Concluding Comments


Chapter 12 Role of Calmodulin in Dopaminergic Transmission

I. Dopamine Receptors as Supramolecular Entities

II. Calmodulin Modulation of Adenylate Cyclase

III. Release of Calmodulin by Membrane Phosphorylation

IV. Calmodulin as a Possible Modulator of Dopamine Receptors

V. Receptor-Mediated Modulation of Phosphodiesterase: Role of Calmodulin Translocation

VI. Calmodulin Participation in Dopamine Receptor Pharmacology

VII. Conclusions


Chapter 13 Immunocytochemical Localization of Calmodulin in Rat Tissues

I. Introduction

II. Methods

III. Localization of Calmodulin

IV. Questions Raised by Immunocytochemical Localization

V. Concluding Remarks


Chapter 14 Immimocytochemical Studies of the Localization of Calmodulin and CaM-BP80 in Brain

I. Introduction

II. Immunocytochemical Methods

III. Tissue Localization

IV. Functional Considerations


Chapter 15 Calmodulin-Binding Proteins

I. Introduction

II. Heat-Labile Calmodulin-Binding Protein (CaM-BP8o)

III. Heat-Stable Calmodulin-Binding Protein (CaM-BP70)

IV. Other Calmodulin-Binding Proteins


Chapter 16 Mechanisms and Pharmacological Implications of Altering Calmodulin Activity

I. Introduction

II. Distribution of Calmodulin

III. Biochemical Actions of Calmodulin

IV. Alteration of Calmodulin Activity

V. Mechanism of the Drug-Induced Inhibition of Calmodulin Activity

VI. Pharmacological Implications of Inhibiting the Activity of Calmodulin

VII. Summary




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© Academic Press 1980
Academic Press
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About the Editor

Wai Yiu Cheung

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